- Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling
[作者：Lee, J; Giordano, S; Zhang, JH,期刊：Biochemical Journal, 页码：523-540 , 文章类型： Review，,卷期：2012年441-2]
- Reactive oxygen and nitrogen species change cellular responses through diverse mechanisms that are now being defined. At low levels, they are signalling molecules, and at high levels, they damage organelles, particularly...
- Regulation and function of the RSK family of protein kinases
[作者：Romeo, Y; Zhang, XC; Roux, PP,期刊：Biochemical Journal, 页码：553-569 , 文章类型： Review，,卷期：2012年441-2]
- The RSK (90 kDa ribosomal S6 kinase) family comprises a group of highly related serine/threonine kinases that regulate diverse cellular processes, including cell growth, proliferation, survival and motility. This family ...
- Visualization of co-localization in A beta 42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death
[作者：Soura, V; Stewart-Parker, M; Williams, TL; Ratnayaka, A; Atherton, J; Gorringe, K; Tuffin, J; Darwent, E; Rambaran, R; Klein, W; Lacor, P; Staras, K; Thorpe, J; Serpell, LC,期刊：Biochemical Journal, 页码：579-590 , 文章类型： Article，,卷期：2012年441-2]
- A beta 42 [amyloid-beta peptide-(1-42)] plays a central role in Alzheimer's disease and is known to have a detrimental effect on neuronal cell function and survival when assembled into an oligomeric form. In the present ...
- Structure of the mRNA splicing complex component Cwc2: insights into RNA recognition
[作者：Lu, PL; Lu, GF; Yan, CY; Wang, L; Li, WQ; Yin, P,期刊：Biochemical Journal, 页码：591-597 , 文章类型： Article，,卷期：2012年441-2]
- The Prp19-associated complex [NTC (nineteen complex)] plays a crucial role in intron removal during premature mRNA splicing in eukaryotes. Only one component of the NTC, Cwc2, is capable of binding RNA. In the present st...
- Iron-mediated retinal degeneration in haemojuvelin-knockout mice
[作者：Gnana-Prakasam, JP; Tawfik, A; Romej, M; Ananth, S; Martin, PM; Smith, SB; Ganapathy, V,期刊：Biochemical Journal, 页码：599-608 , 文章类型： Article，,卷期：2012年441-2]
- Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE (human leucocyte antigen-like protein involved in iron homoeostasis),...
- Biochemical insight into physiological effects of H(2)S: reaction with peroxynitrite and formation of a new nitric oxide donor, sulfinyl nitrite
[作者：Filipovic, MR; Miljkovic, J; Allgauer, A; Chaurio, R; Shubina, T; Herrmann, M; Ivanovic-Burmazovic, I,期刊：Biochemical Journal, 页码：609-621 , 文章类型： Article，,卷期：2012年441-2]
- The reaction of hydrogen sulfide (H(2)S) with peroxynitrite (a key mediator in numerous pathological states) was studied in vitro and in different cellular models. The results show that H,S can scavenge peroxynitrite wit...
- Metallothioneins protect cytosolic creatine kinases against stress induced by nitrogen-based oxidants
[作者：Chen, Z; Li, J; Zhao, TJ; Li, XH; Meng, FG; Mu, H; Yan, YB; Zhou, HM,期刊：Biochemical Journal, 页码：623-632 , 文章类型： Article，,卷期：2012年441-2]
- The formation of intracellular nitrogen-based oxidants has important physiological and pathological consequences. CK (creatine kinase), which plays a key role in intracellular energy metabolism, is a main target of low c...
- Dab2 is a key regulator of endocytosis and post-endocytic trafficking of the cystic fibrosis transmembrane conductance regulator
[作者：Fu, LW; Rab, A; Tang, LP; Rowe, SM; Bebok, Z; Collawn, JF,期刊：Biochemical Journal, 页码：633-643 , 文章类型： Article，,卷期：2012年441-2]
- CFTR (cystic fibrosis transmembrane conductance regulator) is expressed in the apical membrane of epithelial cells. Cell-surface CFTR levels are regulated by endocytosis and recycling. A number of adaptor proteins includ...
- ADP-ribose polymers localized on Ctcf-Parp1-Dnmt1 complex prevent methylation of Ctcf target sites
[作者：Zampieri, M; Guastafierro, T; Calabrese, R; Ciccarone, F; Bacalini, MG; Reale, A; Perilli, M; Passananti, C; Caiafa, P,期刊：Biochemical Journal, 页码：645-652 , 文章类型： Article，,卷期：2012年441-2]
- PARylation [poly(ADP-ribosyl)ation] is involved in the maintenance of genomic methylation patterns through its control of Dram 1 [DNA (cytosine-5)-methyltransferase 1] activity. Our previous findings indicated that Ctcf ...
- Omega-3 docosahexaenoic acid and procyanidins inhibit cyclo-oxygenase activity and attenuate NF-kappa B activation through a p105/p50 regulatory mechanism in macrophage inflammation
[作者：Martinez-Micaelo, N; Gonzalez-Abuin, N; Terra, X; Richart, C; Ardevol, A; Pinent, M; Blay, M,期刊：Biochemical Journal, 页码：653-663 , 文章类型： Article，,卷期：2012年441-2]
- The inflammatory response has been implicated in the pathogenesis of many chronic diseases. Along these lines, the modulation of inflammation by consuming bioactive food compounds, such as omega-3 fatty acids or procyani...
- The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells
[作者：Xu, CD; Deng, FG; Mao, ZH; Zhang, J; Wang, HJ; Wang, JP; Mu, JG; Deng, SS; Ma, D,期刊：Biochemical Journal, 页码：665-674 , 文章类型： Article，,卷期：2012年441-2]
- TFPI-2 (tissue factor pathway inhibitor-2) has recently been recognized as a new tumour suppressor gene. Low expression of this protein in several types of cancers allows for enhanced tumour growth, invasion and metastas...
- Hypoxia-inducible factor-1 (HIF-1) promotes LDL and VLDL uptake through inducing VLDLR under hypoxia
[作者：Shen, GM; Zhao, YZ; Chen, MT; Zhang, FL; Liu, XL; Wang, Y; Liu, CZ; Yu, J; Zhang, JW,期刊：Biochemical Journal, 页码：675-683 , 文章类型： Article，,卷期：2012年441-2]
- Metabolism under hypoxia is significantly different from that under normoxia. It has been well elucidated that HIF-I (hypoxia-inducible factor-1) plays a central role in regulating glucose metabolism under hypoxia; howev...
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