- Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta(24)-reductase-deficient cell line
[作者:Rodriguez-Acebes, S; de la Cueva, P; Fernandez-Hernando, C; Ferruelo, AJ; Lasuncion, MA; Rawson, RB; Martinez-Botas, J; Gomez-Coronado, D,期刊:Biochemical Journal, 页码:305-315 , 文章类型: Article,,卷期:2009年420-Part 2]
- Cholesterol homoeostasis is critical for cell viability and proliferation. The SREBP (sterol regulatory element-binding protein) pathway is crucial for the maintenance of cholesterol homoeostasis. This pathway is control...
- MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)
[作者:Webb, JD; Muranyi, A; Pugh, CW; Ratcliffe, PJ; Coleman, ML,期刊:Biochemical Journal, 页码:327-333 , 文章类型: Article,,卷期:2009年420-Part 2]
- The asparaginyl hydroxylase FIH (factor inhibiting H IF (hypoxia-inducible)le fector)] Was first identified as a protein that inhibits transcriptional activation by HIF, through hydroxylation of all asparagine residue in...
- Lateral organization of membrane proteins: tetraspanins spin their web
[作者:Charrin, S; Le Naour, F; Silvie, O; Milhiet, PE; Boucheix, C; Rubinstein, E,期刊:Biochemical Journal, 页码:133-154 , 文章类型: Review,,卷期:2009年420-Part 2]
- Despite high expression levels at the plasma membrane or in intracellular vesicles, tetraspanins remain among the most mysterious transmembrane molecules 20 years after their discovery. Several genetic studies in mammals...
- Identification of a conserved F-box protein 6 interactor essential for endocytosis and cytokinesis in fission yeast
[作者:Jourdain, I; Spielewoy, N; Thompson, J; Dhut, S; Yates, JR; Toda, T,期刊:Biochemical Journal, 页码:169-177 , 文章类型: Article,,卷期:2009年420-Part 2]
- The F-box domain is a degenerated motif consisting of similar to 40 amino acid residues that specifically bind Skp1, a core component of the SCF (Skp1-Cdc53/Cullin 1-F-box protein) ubiquitin ligase. Recent work, mainly p...
- Identification and characterization of the lipid-binding property of GrIR, a locus of enterocyte effacement regulator
[作者:Jobichen, C; Fernandis, AZ; Velazquez-Campoy, A; Leung, KY; Mok, YK; Wenk, MR; Sivaraman, J,期刊:Biochemical Journal, 页码:191-199 , 文章类型: Article,,卷期:2009年420-Part 2]
- Lipocalins are it broad family of proteins identified initially in eukaryotes and more recently in Gram-negative bacteria. The functions of lipocalin or lipid-binding proteins are often elusive and very diverse. Recently...
- The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection
[作者:Burger-van Paassen, N; Vincent, A; Puiman, PJ; van der Sluis, M; Bouma, J; Boehm, G; van Goudoever, JB; Van Seuningen, I; Renes, IB,期刊:Biochemical Journal, 页码:211-219 , 文章类型: Article,,卷期:2009年420-Part 2]
- SCFAs (short-chain fatty acids). fermentation products of bacteria, influence epithelial-Specific gene expression. We hypothesize that SCFAs affect goblet-cell-specific mucin MUC2 expression and thereby alter epithelial ...
- GIcNAcstatins are nanomolar inhibitors of human O-GIcNAcase inducing cellular hyper-O-GIcNAcylation
[作者:Dorfmueller, HC; Borodkin, VS; Schimpl, M; van Aalten, DMF,期刊:Biochemical Journal, 页码:221-227 , 文章类型: Article,,卷期:2009年420-Part 2]
- O-GlcNAcylation is an essential, dynamic and inducible post-translational glycosylation of cytosolic proteins in metazoa and can show interplay with protein phosphorylation. Inhibition of OGA (O-GlcNAcase), the enzyme th...
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