- Commitment of 1-Methyl-4-phenylpyrinidinium Ion-induced Neuronal Cell Death by Proteasome-mediated Degradation of p35 Cyclin-dependent Kinase 5 Activator
[作者:Endo, R; Saito, T; Asada, A; Kawahara, H; Ohshima, T; Hisanaga, S,期刊:Journal of Biological Chemistry, 页码:26029-26039 , 文章类型: Article,,卷期:2009年284-38]
- The dysfunction of proteasomes and mitochondria has been implicated in the pathogenesis of Parkinson disease. However, the mechanism by which this dysfunction causes neuronal cell death is unknown. We studied the role of...
- Isolation and Characterization of a High Affinity Peptide Inhibitor of ClC-2 Chloride Channels
[作者:Thompson, CH; Olivetti, PR; Fuller, MD; Freeman, CS; McMaster, D; French, RJ; Pohl, J; Kubanek, J; Mccarty, NA,期刊:Journal of Biological Chemistry, 页码:26051-26062 , 文章类型: Article,,卷期:2009年284-38]
- The ClC protein family includes voltage-gated chloride channels and chloride/proton exchangers. In eukaryotes, ClC proteins regulate membrane potential of excitable cells, contribute to epithelial transport, and aid in l...
- Mapping of the Functional Boundaries and Secondary Structure of the Mouse Mammary Tumor Virus Rem-responsive Element
[作者:Mertz, JA; Chadee, AB; Byun, H; Russell, R; Dudley, JP,期刊:Journal of Biological Chemistry, 页码:25642-25652 , 文章类型: Article,,卷期:2009年284-38]
- Mouse mammary tumor virus (MMTV) is a complex retrovirus that encodes at least three regulatory and accessory proteins, including Rem. Rem is required for nuclear export of unspliced viral RNA and efficient expression of...
- Dissecting an Allosteric Switch in Caspase-7 Using Chemical and Mutational Probes
[作者:Hardy, JA; Wells, JA,期刊:Journal of Biological Chemistry, 页码:26063-26069 , 文章类型: Article,,卷期:2009年284-38]
- Apoptotic caspases, such as caspase-7, are stored as inactive protease zymogens, and when activated, lead to a fate-determining switch to induce cell death. We previously discovered small molecule thiol-containing inhibi...
- PARP-1 Deficiency Increases the Severity of Disease in a Mouse Model of Multiple Sclerosis
[作者:Selvaraj, V; Soundarapandian, MM; Chechneva, O; Williams, AJ; Sidorov, MK; Soulika, AM; Pleasure, DE; Deng, WB,期刊:Journal of Biological Chemistry, 页码:26070-26084 , 文章类型: Article,,卷期:2009年284-38]
- Poly(ADP-ribose) polymerase-1 (PARP-1) has been implicated in the pathogenesis of several central nervous system (CNS) disorders. However, the role of PARP-1 in autoimmune CNS injury remains poorly understood. Therefore,...
- Syndecan-1 Is Required for Robust Growth, Vascularization, and Metastasis of Myeloma Tumors in Vivo
[作者:Khotskaya, YB; Dai, YM; Ritchie, JP; MacLeod, V; Yang, Y; Zinn, K; Sanderson, RD,期刊:Journal of Biological Chemistry, 页码:26085-26095 , 文章类型: Article,,卷期:2009年284-38]
- Myeloma tumors are characterized by high expression of syndecan-1 (CD138), a heparan sulfate proteoglycan present on the myeloma cell surface and shed into the tumor microenvironment. High levels of shed syndecan-1 in th...
- Peptide-Major Histocompatibility Complex Dimensions Control Proximal Kinase-Phosphatase Balance during T Cell Activation
[作者:Choudhuri, K; Parker, M; Milicic, A; Cole, DK; Shaw, MK; Sewell, AK; Stewart-Jones, G; Dong, T; Gould, KG; van der Merwe, PA,期刊:Journal of Biological Chemistry, 页码:26096-26105 , 文章类型: Article,,卷期:2009年284-38]
- T cell antigen recognition requires binding of the T cell receptor (TCR) to a complex between peptide antigen and major histocompatibility complex molecules (pMHC), and this recognition occurs at the interface between th...
- Effect of Conformational Dynamics on Substrate Recognition and Specificity as Probed by the Introduction of a de Novo Disulfide Bond into Cytochrome P450 2B1
[作者:Zhang, HM; Kenaan, C; Hamdane, D; Hoa, GHB; Hollenberg, PF,期刊:Journal of Biological Chemistry, 页码:25678-25686 , 文章类型: Article,,卷期:2009年284-38]
- The conformational dynamics of cytochrome P450 2B1 (CYP2B1) were investigated through the introduction of a disulfide bond to link the I- and K-helices by generation of a double Cys variant, Y309C/S360C. The consequences...
- The RNA-binding Motif Protein 15B (RBM15B/OTT3) Acts as Cofactor of the Nuclear Export Receptor NXF1
[作者:Uranishi, H; Zolotukhin, AS; Lindtner, S; Warming, S; Zhang, GM; Bear, J; Copeland, NG; Jenkins, NA; Pavlakis, GN; Felber, BK,期刊:Journal of Biological Chemistry, 页码:26106-26116 , 文章类型: Article,,卷期:2009年284-38]
- The human SPEN family proteins SHARP, RBM15/OTT1, and RBM15B/OTT3 share the structural domain architecture but show distinct functional properties. Here, we examined the function of OTT3 and compared it with its paralogu...
- New Insights into the Early Steps of Phosphatidylinositol Mannoside Biosynthesis in Mycobacteria PimB' IS AN ESSENTIAL ENZYME OF MYCOBACTERIUM SMEGMATIS
[作者:Guerin, ME; Kaur, D; Somashekar, BS; Gibbs, S; Gest, P; Chatterjee, D; Brennan, PJ; Jackson, M,期刊:Journal of Biological Chemistry, 页码:25687-25696 , 文章类型: Article,,卷期:2009年284-38]
- Phosphatidyl-myo-inositol mannosides (PIMs) are key glycolipids of the mycobacterial cell envelope. They are considered not only essential structural components of the cell but also important molecules implicated in host...
- Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design
[作者:Kerr, ID; Lee, JH; Farady, CJ; Marion, R; Rickert, M; Sajid, M; Pandey, KC; Caffrey, CR; Legac, J; Hansell, E; McKerrow, JH; Craik, CS; Rosenthal, PJ; Brinen, LS,期刊:Journal of Biological Chemistry, 页码:25697-25703 , 文章类型: Article,,卷期:2009年284-38]
- Cysteine proteases of the papain superfamily are implicated in a number of cellular processes and are important virulence factors in the pathogenesis of parasitic disease. These enzymes have therefore emerged as promisin...
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