- Myocardial Structure and Matrix Metalloproteinases
[作者:Aggeli, C; Pietri, P; Felekos, I; Rautopoulos, L; Toutouzas, K; Tsiamis, E; Stefanadis, C,期刊:Current Topics in Medicinal Chemistry, 页码:1113-1131 , 文章类型: Review,,卷期:2012年12-10]
- Metalloproteinases (MMPs) are enzymes which enhance proteolysis of extracellular matrix proteins. The pathophysiologic and prognostic role of MMPs has been demonstrated in numerous studies. The present review covers a wi...
- Inflammatory Mechanisms in Atherosclerosis: The Impact of Matrix Metalloproteinases
[作者:Siasos, G; Tousoulis, D; Kioufis, S; Oikonomou, E; Siasou, Z; Limperi, M; Papavassiliou, AG; Stefanadis, C,期刊:Current Topics in Medicinal Chemistry, 页码:1132-1148 , 文章类型: Review,,卷期:2012年12-10]
- Inflammatory process is essential for the initiation and progression of vascular remodeling, entailing degradation and reorganization of the extra-cellular matrix (ECM) scaffold of the vessel wall, leading to the develop...
- The Role of Matrix Metalloproteinases in Essential Hypertension
[作者:Androulakis, E; Tousoulis, D; Papageorgiou, N; Latsios, G; Siasos, G; Stefanadis, C,期刊:Current Topics in Medicinal Chemistry, 页码:1149-1158 , 文章类型: Review,,卷期:2012年12-10]
- The matrix metalloproteinases/tissue inhibitors of metalloproteinases system is involved in the regulation of extracellular matrix metabolism, which plays a crucial role with regards to maintenance of tissue integrity. D...
- Matrix Metalloproteinases and Vulnerable Atheromatous Plaque
[作者:Toutouzas, K; Synetos, A; Nikolaou, C; Tsiamis, E; Tousoulis, D; Stefanadis, C,期刊:Current Topics in Medicinal Chemistry, 页码:1166-1180 , 文章类型: Review,,卷期:2012年12-10]
- Atherosclerotic coronary artery disease, the underlying basis for ischemic heart disease, is the leading cause of death and disability in the USA and recent trends indicate that coronary artery disease is also becoming a...
- Matrix Metallopropteinases in Heart Failure
[作者:Tousoulis, D; Kampoli, AM; Papageorgiou, N; Antoniades, C; Siasos, G; Latsios, G; Tsiamis, E; Stefanadis, C,期刊:Current Topics in Medicinal Chemistry, 页码:1181-1191 , 文章类型: Review,,卷期:2012年12-10]
- Heart failure (HF) represents a complex multifactorial syndrome, characterized by crucial structural and functional abnormalities of the myocardium. Matrix metalloproteinases are associated with left ventricular dysfunct...
- Matrix Metalloproteinases in Acute Coronary Syndromes: Current Perspectives
[作者:Kampoli, AM; Tousoulis, D; Papageorgiou, N; Antoniades, C; Androulakis, E; Tsiamis, E; Latsios, G; Stefanadis, C,期刊:Current Topics in Medicinal Chemistry, 页码:1192-1205 , 文章类型: Review,,卷期:2012年12-10]
- Matrix metalloproteinases (MMPs) are a family of zinc metallo-endopeptidases secreted by cells and are responsible for much of the turnover of matrix components. Several studies have shown that MMPs are involved in all s...
- Genetic Variability of Matrix Metalloproteinase Genes in Cardiovascular Disease
[作者:Papageorgiou, N; Tousoulis, D; Hatzis, G; Briasoulis, A; Androulakis, E; Giolis, A; Siasos, G; Latsios, G; Vogiatzi, G; Tentolouris, C; Stefanadis, C,期刊:Current Topics in Medicinal Chemistry, 页码:1206-1213 , 文章类型: Review,,卷期:2012年12-10]
- It is well established that matrix metalloproteinases (MMPs) contribute to the degradation of the extracellular matrix of coronary plaque and contribute to the thinning of the fibrous cap. As a result, the atheromatous p...
- Novel Therapeutic Approaches Targeting Matrix Metalloproteinases in Cardiovascular Disease
[作者:Briasoulis, A; Tousoulis, D; Papageorgiou, N; Kampoli, AM; Androulakis, E; Antoniades, C; Tsiamis, E; Latsios, G; Stefanadis, C,期刊:Current Topics in Medicinal Chemistry, 页码:1214-1221 , 文章类型: Review,,卷期:2012年12-10]
- Matrix metalloproteinases (MMPs), are proteinases that participate in extracellular matrix remodelling and degradation. Under normal physiological conditions, the activities of MMPs are regulated at the level of transcri...
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