- Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma
[作者：Ellis, L; Pan, Y; Smyth, GK; George, DJ; McCormack, C; Williams-Truax, R; Mita, M; Beck, J; Burris, H; Ryan, G; Atadja, P; Butterfoss, D; Dugan, M; Culver, K; Johnstone, RW; Prince, HM,期刊：Clinical Cancer Research, 页码：4500-4510 , 文章类型： Article，,卷期：2008年14-14]
- Purpose: Histone deacetylase inhibitors can alter gene expression and mediate diverse antitumor activities. Herein, we report the safety and activity of the histone deacetylase inhibitor panobinostat (LBH589) in cutaneou...
- Analysis and reproducibility of 3 '-deoxy-3 '-[F-18]fluorothymidine positron emission tomography imaging in patients with non-small cell lung cancer
[作者：Shields, AF; Lawhorn-Crews, JM; Briston, DA; Zalzala, S; Gadgeel, S; Douglas, KA; Mangner, TJ; Heilbrun, LK; Muzik, O,期刊：Clinical Cancer Research, 页码：4463-4468 , 文章类型： Article，,卷期：2008年14-14]
- Purpose: Imaging tumor proliferation with 3'-deoxy-3'-[F-18]fluorothymidine (FLT) and positron emission tomography is being developed with the goal of monitoring antineoplastic therapy. This study assessed the methods to...
- Irradiance-dependent photobleaching and pain in delta-aminolevulinic acid-photodynamic therapy of superficial basal cell carcinomas
[作者：Cottrell, WJ; Paquette, AD; Keymel, KR; Foster, TH; Oseroff, AR,期刊：Clinical Cancer Research, 页码：4475-4483 , 文章类型： Article，,卷期：2008年14-14]
- Purpose: In superficial basal cell carcinomas treated with photodynamic therapy with topical delta-aminolevulinic acid, we examined effects of light irradiance on photodynamic efficiency and pain. The rate of singlet-oxy...
- RLIP76 and cancer
[作者：Awasthi, S; Singhal, SS; Awasthi, YC; Martin, B; Woo, JH; Cunningham, CC; Frankel, AE,期刊：Clinical Cancer Research, 页码：4372-4377 , 文章类型： Article，,卷期：2008年14-14]
- RLIP76 is a multifunctional membrane protein that transports glutathione conjugates of electrophilic compounds and other xenobiotics including chemotherapy agents out of cells. The protein is overexpressed in lung carcin...
- Ixabepilone in combination with capecitabine and as monotherapy for treatment of advanced breast cancer refractory to previous chemotherapies
[作者：Lechleider, RJ; Kaminskas, E; Jiang, XP; Aziz, R; Bullock, J; Kasliwal, R; Harapanhalli, R; Pope, S; Sridhara, R; Leighton, J; Booth, B; Dagher, R; Justice, R; Pazdur, R,期刊：Clinical Cancer Research, 页码：4378-4384 , 文章类型： Article，,卷期：2008年14-14]
- Purpose: To describe the considerations leading to marketing approval of ixabepilone in combination with capecitabine and as monotherapy for the treatment of advanced breast cancer that is refractory to other chemotherap...
- Intratumoral estrogens and estrogen receptors in human non-small cell lung carcinoma
[作者：Niikawa, H; Suzuki, T; Miki, Y; Suzuki, S; Nagasaki, S; Akahira, J; Honma, S; Evans, DB; Hayashi, S; Kondo, T; Sasano, H,期刊：Clinical Cancer Research, 页码：4417-4426 , 文章类型： Article，,卷期：2008年14-14]
- Purpose: The possible involvement of gender-dependent factors has been suggested in human non-small cell lung carcinomas (NSCLC), but their precise roles remain largely unclear. Therefore, we examined intratumoral estrad...
- Genomic differences between pure ductal carcinoma in situ of the breast and that associated with invasive disease: a calibrated aCGH study
[作者：Iakovlev, VV; Arneson, NCR; Wong, V; Wang, CJ; Leung, S; Iakovleva, G; Warren, K; Pintilie, M; Done, SJ,期刊：Clinical Cancer Research, 页码：4446-4454 , 文章类型： Article，,卷期：2008年14-14]
- Purpose: In the quest for new targets, genomes of ductal carcinoma in situ (DCIS) and infiltrating duct carcinoma (IDC) have been compared previously; however, genomic alterations associated with cancer progression were ...
- A phase I and pharmacokinetic study of lapatinib in combination with letrozole in patients with advanced cancer
[作者：Chu, QSC; Cianfrocca, ME; Goldstein, LJ; Gale, M; Murray, N; Loftiss, J; Arya, N; Koch, KM; Pandite, L; Fleming, RA; Paul, E; Rowinsky, EK,期刊：Clinical Cancer Research, 页码：4484-4490 , 文章类型： Article，,卷期：2008年14-14]
- Purpose: The main objectives of this phase I and pharmacokinetic, open-label study were to determine the optimally tolerated regimen (OTR), safety, pharmacokinetics, and clinical activity of lapatinib in combination with...
- Function of junB in transient amplifying cell senescence and progression of human prostate cancer
[作者：Konishi, N; Shimada, K; Nakamura, M; Ishida, E; Ota, I; Tanaka, N; Fujimoto, K,期刊：Clinical Cancer Research, 页码：4408-4416 , 文章类型： Article，,卷期：2008年14-14]
- Purpose: Replicative senescence in cells acts as a barrier against excessive proliferation and carcinogenesis. Transient amplifying cells (TAC) are a subset of basal cell populations within the prostate from which cancer...
- Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cells
[作者：Thakur, A; Sun, Y; Bollig, A; Wu, J; Biliran, H; Banerjee, S; Sarkar, FH; Liao, DJ,期刊：Clinical Cancer Research, 页码：4427-4436 , 文章类型： Article，,卷期：2008年14-14]
- Purpose: We have previously shown that p90 ribosomal protein S6 kinase 4 (RSK4), an X-linked gene, is highly up-regulated in mammary tumors of MMTV-c-Myc transgenic mice. In this study, we further investigated whether RS...
- Transformation by oncogenic mutants and ligand-dependent activation of FLT3 wild-type requires the tyrosine residues 589 and 591
[作者：Vempati, S; Reindl, C; Wolf, U; Kern, R; Petropoulos, K; Naidu, VM; Buske, C; Hiddemann, W; Kohl, TM; Spiekermann, K,期刊：Clinical Cancer Research, 页码：4437-4445 , 文章类型： Article，,卷期：2008年14-14]
- Purpose: Mutations in the receptor tyrosine kinase FLT3 are found in up to 30% of acute myelogenous leukemia patients and are associated with an inferior prognosis. In this study, we characterized critical tyrosine resid...
- Expression of Aurora a (but not Aurora B) is predictive of survival in breast cancer
[作者：Nadler, Y; Camp, RL; Schwartz, C; Rimm, DL; Kluger, HM; Kluger, Y,期刊：Clinical Cancer Research, 页码：4455-4462 , 文章类型： Article，,卷期：2008年14-14]
- Purpose: The cell cycle mediators Aurora A and B are targets of drugs currently in clinical development. As with other targeted therapies in breast cancer, response to therapy might be associated with target expression i...
- Visualization of circulating melanoma cells in peripheral blood of patients with primary weal melanoma
[作者：Ulmer, A; Beutel, J; Susskind, D; Hilgers, RD; Ziemssen, F; Luke, M; Rocken, M; Rohrbach, M; Fierlbeck, G; Bartz-Schmidt, KU; Grisanti, S,期刊：Clinical Cancer Research, 页码：4469-4474 , 文章类型： Article，,卷期：2008年14-14]
- Purpose: In patients with uveal melanoma, tumor cell dissemination and subsequent formation of metastases are confined mainly to the hematogenous route. Here, we sought to isolate circulating melanoma cells in peripheral...
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