- Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells
[作者:Bianco, R; Rosa, R; Damiano, V; Daniele, G; Gelardi, T; Garofalo, S; Tarallo, V; De Falco, S; Melisi, D; Benelli, R; Albini, A; Ryan, A; Ciardiello, F; Tortora, G,期刊:Clinical Cancer Research, 页码:5069-5080 , 文章类型: Article,,卷期:2008年14-16]
- Purpose:The resistance to selective EGFR inhibitors involves the activation of alternative signaling pathways, and Akt activation and VEGF induction have been described in EGFR inhibitor resistant tumors. Combined inhibi...
- Survivin: Key regulator of mitosis and apoptosis and novel target for cancer therapeutics
[作者:Mita, AC; Mita, MM; Nawrocki, ST; Giles, FJ,期刊:Clinical Cancer Research, 页码:5000-5005 , 文章类型: Article,,卷期:2008年14-16]
- Survivin, a member of the family of inhibitor of apoptosis proteins, functions as a key regulator of mitosis and programmed cell death. Initially, survivin was described as an inhibitor of caspase-9. However, over the la...
- Vandetanib inhibits growth of adenoid cystic carcinoma in an orthotopic nude mouse model
[作者:Choi, S; Sano, D; Cheung, M; Zhao, M; Jasser, SA; Ryan, AJ; Mao, L; Chen, WT; El-Naggar, AK; Myers, JN,期刊:Clinical Cancer Research, 页码:5081-5089 , 文章类型: Article,,卷期:2008年14-16]
- Purpose: Adenoid cystic carcinoma (ACC) can often be controlled with surgery and postoperative adjuvant radiotherapy but is also characterized by late local recurrence and distant metastasis. No effective systemic therap...
- Overexpression of stromal cell-derived factor 1 and its receptor CXCR4 induces autocrine/paracrine cell proliferation in human pituitary adenomas
[作者:Barbieri, F; Bajetto, A; Stumm, R; Pattarozzi, A; Porcile, C; Zona, G; Dorcaratto, A; Ravetti, JL; Minuto, F; Spaziante, R; Schettini, G; Ferone, D; Florio, T,期刊:Clinical Cancer Research, 页码:5022-5032 , 文章类型: Article,,卷期:2008年14-16]
- Purpose: Hypothalamic or locally produced growth factors and cytokines control pituitary development, functioning, and cell division. We evaluated the expression of the chemokine stromal cell-derived factor 1 (SDF1) and ...
- Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptors
[作者:David, E; Sinha, R; Chen, J; Sun, SY; Kaufman, JL; Lonial, S,期刊:Clinical Cancer Research, 页码:5090-5098 , 文章类型: Article,,卷期:2008年14-16]
- Purpose: The aim of this study is to investigate the efficacy of a novel Akt inhibitor, perifosine, in combination with tumor necrosis factor - related apoptosis-inducing ligand (TRAIL) in human myeloma cells and primary...
- Enhanced antitumor therapy by inhibition of p21(waf1) in human malignant mesothelioma
[作者:Lazzarini, R; Moretti, S; Orecchia, S; Betta, PG; Procopio, A; Catalano, A,期刊:Clinical Cancer Research, 页码:5099-5107 , 文章类型: Article,,卷期:2008年14-16]
- Purpose: The p21 cyclin-dependent kinase inhibitor was frequently expressed in human malignant pleural mesothelioma (MPM) tissues as well as cell lines. Recent data indicate that p21 keeps tumor cells alive after DNA dam...
- Midkine enhances soft-tissue sarcoma growth: A possible novel therapeutic target
[作者:Jin, Z; Lahat, G; Korchin, B; Nguyen, T; Zhu, QS; Wang, XM; Lazar, AJ; Trent, J; Pollock, RE; Lev, D,期刊:Clinical Cancer Research, 页码:5033-5042 , 文章类型: Article,,卷期:2008年14-16]
- Purpose: New therapeutic targets for soft-tissue sarcoma (STS) treatment are critically needed. Midkine (MK), a multifunctional cytokine, is expressed during midgestation but is highly restricted in normal adult tissues....
- Multimodality therapy: Potentiation of high linear energy transfer radiation with paclitaxel for the treatment of disseminated peritoneal disease
[作者:Milenic, DE; Garmestani, K; Brady, ED; Baidoo, KE; Albert, PS; Wong, KJ; Flynn, J; Brechbiel, M,期刊:Clinical Cancer Research, 页码:5108-5115 , 文章类型: Article,,卷期:2008年14-16]
- Purpose: Studies herein explore paclitaxel enhancement of the therapeutic efficacy of alpha-particle-targeted radiation therapy.Experimental Design: Athymic mice bearing 3 day i.p. LS-174T xenografts were treated with 30...
- Proteasome inhibition activates epidermal growth factor receptor (EGFR) and EGFR-independent mitogenic kinase signaling pathways in pancreatic cancer cells
[作者:Sloss, CM; Wang, F; Liu, R; Xia, LJ; Houston, M; Ljungman, D; Palladino, MA; Cusack, JC,期刊:Clinical Cancer Research, 页码:5116-5123 , 文章类型: Article,,卷期:2008年14-16]
- Purpose: In the current study, we investigate the activation of antiapoptotic signaling pathways in response to proteasome inhibitor treatment in pancreatic cancer and evaluate the use of concomitant inhibition of these ...
- Nonredundant functions for tumor protein D52-like proteins support specific targeting of TPD52
[作者:Shehata, M; Bieche, I; Boutros, R; Weidenhofer, J; Fanayan, S; Spalding, L; Zeps, N; Byth, K; Bright, RK; Lidereau, R; Byrne, JA,期刊:Clinical Cancer Research, 页码:5050-5060 , 文章类型: Article,,卷期:2008年14-16]
- Purpose: Tumor protein D52 (TPD52 or D52) is frequently overexpressed in breast and other cancers and present at increased gene copy number. It is, however, unclear whether D52 amplification and overexpression target spe...
- COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis
[作者:Ma, NF; Lau, SH; Hu, L; Xie, D; Wu, J; Yang, J; Wang, Y; Wu, MC; Fung, J; Bai, XY; Tzang, CH; Fu, L; Yang, MS; Su, YA; Guan, XY,期刊:Clinical Cancer Research, 页码:5061-5068 , 文章类型: Article,,卷期:2008年14-16]
- Purpose: X protein (HBx), a product of hepatitis B virus, has been closely associated with the development of hepatocellular carcinoma (HCC). Based on observations that the COOH-terminal truncated HBx was frequently dete...
- Effect of rapamycin alone and in combination with sorafenib in an orthotopic model of human hepatocellular carcinoma
[作者:Wang, Z; Zhou, J; Fan, J; Qiu, SJ; Yu, Y; Huang, XW; Tang, ZY,期刊:Clinical Cancer Research, 页码:5124-5130 , 文章类型: Article,,卷期:2008年14-16]
- Purpose: Novel therapeutic strategies are needed to prevent the tumor recurrence or metastasis after liver transplantation for hepatocellular carcinoma (HCC). This study was to investigate the effect of rapamycin, alone ...
- Deletion of 1p32-p36 is the most frequent genetic change and poor prognostic marker in adenoid cystic carcinoma of the salivary glands
[作者:Rao, PH; Roberts, D; Zhao, YJ; Bell, D; Harris, CP; Weber, RS; El-Naggar, AK,期刊:Clinical Cancer Research, 页码:5181-5187 , 文章类型: Article,,卷期:2008年14-16]
- Purpose: Adenoid cystic carcinoma (ACC) is a relatively uncommon salivary gland malignancy known for its protean phenotypic features and pernicious clinical behavior. Currently, no effective therapy is available for pati...
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