- Oncostatin M induces bone loss and sensitizes rat osteosarcoma to the antitumor effect of midostaurin in vivo
[作者:Brounais, B; Chipoy, C; Mori, K; Charrier, C; Battaglia, S; Pilet, P; Richards, CD; Heymann, D; Redini, F; Blanchard, F,期刊:Clinical Cancer Research, 页码:5400-5409 , 文章类型: Article,,卷期:2008年14-17]
- Purpose: In cultures, the cytokine oncostatin M (OSM) reduces the growth and induces differentiation of osteoblasts and osteosarcoma cells into glial/osteocytic cells. Moreover, OSM sensitizes these cells to apoptosis dr...
- Postradiation sensitization of the histone deacetylase inhibitor valproic acid
[作者:Chinnaiyan, P; Cerna, D; Burgan, WE; Beam, K; Williams, ES; Camphausen, K; Tofilon, PJ,期刊:Clinical Cancer Research, 页码:5410-5415 , 文章类型: Article,,卷期:2008年14-17]
- Purpose: Preclinical studies evaluating histone deacetylase (HDAC) inhibitor-induced radiosensitization have largely focused on the preirradiation setting based on the assumption that enhanced radiosensitivity was mediat...
- Inhibition of the p53 E3 ligase HDM-2 induces apoptosis and DNA damage - Independent p53 phosphorylation in mantle cell lymphoma
[作者:Jones, RJ; Chen, Q; Voorhees, PM; Young, KH; Bruey-Sedano, N; Yang, DJ; Orlowski, RZ,期刊:Clinical Cancer Research, 页码:5416-5425 , 文章类型: Article,,卷期:2008年14-17]
- Purpose: The ubiquitin-proteasome pathway has been validated as a target in non - Hodgkin's lymphoma through demonstration of the activity of the proteasome inhibitor bortezomib.Experimental Design: Another potentially a...
- Tasigna for chronic and accelerated phase Philadelphia chromosome-positive chronic myelogenous leukemia resistant to or intolerant of imatinib
[作者:Hazarika, M; Jiang, XP; Liu, Q; Lee, SL; Ramchandani, R; Garnett, C; Orr, MS; Sridhara, R; Booth, B; Leighton, JK; Timmer, W; Harapanhalli, R; Dagher, R; Justice, R; Pazdur, R,期刊:Clinical Cancer Research, 页码:5325-5331 , 文章类型: Article,,卷期:2008年14-17]
- Purpose: This Food and Drug Administration (FDA) approval report describes the data and analyses leading to the approval by the FDA of nilotinib (Tasigna, AMN-107; Novartis Pharmaceuticals Corporation), an inhibitor of B...
- Expanding the roles for pregnane X receptor in cancer: Proliferation and drug resistance in ovarian cancer
[作者:Gupta, D; Venkatesh, M; Wang, HW; Kim, S; Sinz, M; Goldberg, GL; Whitney, K; Longley, C; Mani, S,期刊:Clinical Cancer Research, 页码:5332-5340 , 文章类型: Article,,卷期:2008年14-17]
- Purpose: We examined the presence of the pregnane X receptor (PXR) and its effects on ovarian cancer cells after activation by its cognate ligand.Experimental Design: SKOV-3 and OVCAR-8 ovarian carcinoma cells were analy...
- beta 2-microglobulin signaling blockade inhibited androgen receptor axis and caused apoptosis in human prostate cancer cells
[作者:Huang, WC; Havel, JJ; Zhau, HE; Qian, WP; Lue, HW; Chu, CY; Nomura, T; Chung, LWK,期刊:Clinical Cancer Research, 页码:5341-5347 , 文章类型: Article,,卷期:2008年14-17]
- Purpose: beta 2-Microglobulin (beta 2M) has been shown to promote osteomimicry and the proliferation of human prostate cancer cells. The objective of this study is to determine the mechanism by which targeting beta 2M us...
- Association of an extracellular matrix gene cluster with breast cancer prognosis and endocrine therapy response
[作者:Helleman, J; Jansen, MPHM; Ruigrok-Ritstier, K; van Staveren, IL; Look, MP; Gelder, MEM; Sieuwerts, AM; Klijn, JGM; Sleijfer, S; Foekens, JA; Berns, EMJJ,期刊:Clinical Cancer Research, 页码:5555-5564 , 文章类型: Article,,卷期:2008年14-17]
- Purpose: We previously discovered an extracellular matrix (ECM) gene cluster associated with resistance to first-line tamoxifen therapy of patients with metastatic breast cancer. In this study, we determined whether the ...
- Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas
[作者:Kikuchi, S; Honda, K; Tsuda, H; Hiraoka, N; Imoto, I; Kosuge, T; Umaki, T; Onozato, K; Shitashige, M; Yamaguchi, U; Ono, M; Tsuchida, A; Aoki, T; Inazawa, J; Hirohashi, S; Yamada, T,期刊:Clinical Cancer Research, 页码:5348-5356 , 文章类型: Article,,卷期:2008年14-17]
- Purpose: An invasive growth pattern is one of the hallmarks of pancreatic ductal carcinoma. Actinin-4 is an actin-binding protein associated with enhanced cell motility, invasive growth, and lymph node metastasis. Actini...
- Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression
[作者:Kleer, CG; Bloushtain-Qimron, N; Chen, YH; Carrasco, D; Hu, M; Yao, J; Kraeft, SK; Collins, LC; Sabel, MS; Argani, P; Gelman, R; Schnitt, SJ; Krop, IE; Polyak, K,期刊:Clinical Cancer Research, 页码:5357-5367 , 文章类型: Article,,卷期:2008年14-17]
- Purpose: To evaluate the expression of cathepsin K (CTSK) and CXCL14 in stroma land epithelial cells in human breast tumor progression.Experimental Design: We did immunohistochemical analyses of CTSK and CXCL14 expressio...
- Induction of receptor for advanced glycation end products by EBV latent membrane protein 1 and its correlation with angiogenesis and cervical lymph node metastasis in nasopharyngeal carcinoma
[作者:Tsuji, A; Wakisaka, N; Kondo, S; Murono, S; Furukawa, M; Yoshizaki, T,期刊:Clinical Cancer Research, 页码:5368-5375 , 文章类型: Article,,卷期:2008年14-17]
- Purpose: The EBV oncoprotein, latent membrane protein 1 (LMP1), contributes to the metastasis of nasopharyngeal carcinoma (NPC) by inducing factors to promote tumor invasion and angiogenesis. The receptor for advanced gl...
- Overexpression of the zinc uptake transporter hZIP1 inhibits nuclear factor-kappa B and reduces the malignant potential of prostate cancer cells in vitro and in vivo
[作者:Golovine, K; Makhov, P; Uzzo, RG; Shaw, T; Kunkle, D; Kolenko, VM,期刊:Clinical Cancer Research, 页码:5376-5384 , 文章类型: Article,,卷期:2008年14-17]
- Purpose: Intracellular zinc levels and expression of the zinc uptake transporter, hZIP1, are markedly down-regulated in prostate adenocarcinomatous tissue compared with normal prostate tissue. Our previous studies have s...
- Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation
[作者:Zhang, G; Park, MA; Mitchell, C; Hamed, H; Rahmani, M; Martin, AP; Curiel, DT; Yacoub, A; Graf, M; Lee, R; Roberts, JD; Fisher, PB; Grant, S; Dent, P,期刊:Clinical Cancer Research, 页码:5385-5399 , 文章类型: Article,,卷期:2008年14-17]
- Purpose and Design: Mechanism(s) by which the multikinase inhibitor sorafenib and the histone deacetylase inhibitor vorinostat interact to kill hepatic, renal, and pancreatic adenocarcinoma cells has been defined.Results...
- Matuzumab short-term therapy in experimental pancreatic cancer: Prolonged antitumor activity in combination with gemcitabine
[作者:Kleespies, A; Ischenko, I; Eichhorn, ME; Seeliger, H; Amendt, C; Mantell, O; Jauch, KW; Bruns, CJ,期刊:Clinical Cancer Research, 页码:5426-5436 , 文章类型: Article,,卷期:2008年14-17]
- Purpose: The epidermal growth factor receptor ErbB-1 is commonly expressed in pancreatic cancer and ErbB-1 targeting has shown promising results. We wanted to evaluate matuzumab (EMD72000), a fully humanized ErbB-1-speci...
- Experimental therapy of hepatoma with artemisinin and its derivatives: In vitro and in vivo activity, chemosensitization, and mechanisms of action
[作者:Hou, JM; Wang, DS; Zhang, RW; Wang, H,期刊:Clinical Cancer Research, 页码:5519-5530 , 文章类型: Article,,卷期:2008年14-17]
- Purpose: ART and its derivatives, clinically used antimalarial agents, have recently shown antitumor activities. However, the mechanisms underlying these activities remain unclear. This study was designed to determine th...
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