- Validation of Analytic Methods for Biomarkers Used in Drug Development
[作者:Chau, CH; Rixe, O; McLeod, H; Figg, WD,期刊:Clinical Cancer Research, 页码:5967-5976 , 文章类型: Article,,卷期:2008年14-19]
- The role of biomarkers in drug discovery and development has gained precedence over the years. As biomarkers become integrated into drug development and clinical trials, quality assurance and, in particular, assay valida...
- Expression of Heparanase in Renal Cell Carcinomas: Implications for Tumor Invasion and Prognosis
[作者:Mikami, S; Oya, M; Shimoda, M; Mizuno, R; Ishida, M; Kosaka, T; Mukai, M; Nakajima, M; Okada, Y,期刊:Clinical Cancer Research, 页码:6055-6061 , 文章类型: Article,,卷期:2008年14-19]
- Purpose: Heparanase activity has been detected in many malignant tumors, showing a correlation with the metastatic potential. The present study was undertaken to investigate the expression of heparanase and its prognosti...
- Androgen-Regulated and Highly Tumorigenic Human Prostate Cancer Cell Line Established from a Transplantable Primary CWR22 Tumor
[作者:Dagvadorj, A; Tan, SH; Liao, ZY; Cavalli, LR; Haddad, BR; Nevalainen, MT,期刊:Clinical Cancer Research, 页码:6062-6072 , 文章类型: Article,,卷期:2008年14-19]
- Purpose: One of the major obstacles in understanding the molecular mechanisms underlying the transition of prostate cancer growth from androgen dependency to a hormone-refractory state is the lack of androgen-regulated a...
- Negative Regulation of the Osteoblast Function in Multiple Myeloma through the Repressor Gene E4BP4 Activated by Malignant Plasma Cells
[作者:Silvestris, F; Cafforio, P; De Matteo, M; Calvani, N; Frassanito, MA; Dammacco, F,期刊:Clinical Cancer Research, 页码:6081-6091 , 文章类型: Article,,卷期:2008年14-19]
- Purpose: To explore the pathogenetic mechanisms that suppress the osteoblast function in multiple myeloma because osteogenesis results in defective new bone formation and repair.Experimental Design: Microarray gene analy...
- Epidermal Growth Factor Receptor Mutations in Small Cell Lung Cancer
[作者:Tatematsu, A; Shimizu, J; Murakami, Y; Horio, Y; Nakamura, S; Hida, T; Mitsudomi, T; Yatabe, Y,期刊:Clinical Cancer Research, 页码:6092-6096 , 文章类型: Article,,卷期:2008年14-19]
- Purpose: The vast majority of epidermal growth factor receptor (EGFR) mutations occur in lung adenocarcinoma, and even rare cases of other subtypes with this mutation, such as adenosquamous cell carcinoma, are associated...
- IFN-Induced Transmembrane Protein 1 Promotes Invasion at Early Stage of Head and Neck Cancer Progression
[作者:Hatano, H; Kudo, Y; Ogawa, I; Tsunematsu, T; Kikuchi, A; Abiko, Y; Takata, T,期刊:Clinical Cancer Research, 页码:6097-6105 , 文章类型: Article,,卷期:2008年14-19]
- Purpose: Head and neck squamous cell carcinoma (HNSCC) shows persistent invasion that frequently leads to local recurrence and distant lymphatic metastasis. However, molecular mechanisms associated with invasion of HNSCC...
- Brivanib Alaninate, a Dual Inhibitor of Vascular Endothelial Growth Factor Receptor and Fibroblast Growth Factor Receptor Tyrosine Kinases, Induces Growth Inhibition in Mouse Models of Human Hepatocellular Carcinoma
[作者:Huynh, H; Ngo, VC; Fargnoli, J; Ayers, M; Soo, KC; Koong, HN; Thng, CH; Ong, HS; Chung, A; Chow, P; Pollock, P; Byron, S; Tran, E,期刊:Clinical Cancer Research, 页码:6146-6153 , 文章类型: Article,,卷期:2008年14-19]
- Purpose: Hepatocellular carcinoma (HCC) is the fifth most common primary neoplasm; surgery is the only curative option but 5 -year survival rates are only 25% to 50%. Vascular endothelial growth factor (VEGF) and fibrobl...
- Cotreatment with Vorinostat Enhances Activity of MK-0457 (VX-680) against Acute and Chronic Myelogenous Leukemia Cells
[作者:Fiskus, W; Wang, YC; Joshi, R; Rao, R; Yang, YH; Chen, JG; Kolhe, R; Balusu, R; Eaton, K; Lee, P; Ustun, C; Jillella, A; Buser, CA; Peiper, S; Bhalla, K,期刊:Clinical Cancer Research, 页码:6106-6115 , 文章类型: Article,,卷期:2008年14-19]
- Purpose: We determined the effects of vorinostat (suberoylanalide hydroxamic acid) and/or MK-0457 (VX-680), an Aurora kinase inhibitor on the cultured human (HL-60, OCI-AML3, and K562) and primary acute myelogenous leuke...
- An Immunotolerant HER-2/neu Transgenic Mouse Model of Metastatic Breast Cancer
[作者:Song, H; Shahverdi, K; Huso, DL; Wang, Y; Fox, JJ; Hobbs, RF; Gimi, B; Gabrielson, KL; Pomper, MG; Tsui, BM; Bhujwalla, Z; Reilly, RT; Sgouros, G,期刊:Clinical Cancer Research, 页码:6116-6124 , 文章类型: Article,,卷期:2008年14-19]
- Purpose: Animal models of breast cancer metastases that recapitulate the pattern of metastatic progression seen in patients are lacking; metastatic breast cancer models do not currently exist for evaluation of immune-med...
- Dissociation of Its Opposing Immunologic Effects Is Critical for the Optimization of Antitumor CD8(+) T-Cell Responses Induced by Interleukin 21
[作者:Ansen, S; Butler, MO; Berezovskaya, A; Murray, AP; Stevenson, K; Nadler, LM; Hirano, N,期刊:Clinical Cancer Research, 页码:6125-6136 , 文章类型: Article,,卷期:2008年14-19]
- Purpose: Interleukin 21 (IL-21) is a promising new cytokine, which is undergoing clinical testing as an anticancer agent. Although IL-21 provides potent stimulation of CD8(+) T cells, it has also been suggested that IL-2...
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