- The Type 1 Insulin-Like Growth Factor Receptor Pathway
[作者：Chitnis, MM; Yuen, JSP; Protheroe, AS; Pollak, M; Macaulay, VM,期刊：Clinical Cancer Research, 页码：6364-6370 , 文章类型： Article，,卷期：2008年14-20]
- Research conducted over the past two decades has shown the importance of the type 1 insulin-like growth factor receptor (IGF1R) in tumorigenesis, metastasis, and resistance to existing forms of cancer therapy. The IGF1R ...
- Activation of the RAF/Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase/Extracellular Signal-Regulated Kinase Pathway Mediates Apoptosis Induced by Chelerythrine in Osteosarcorna
[作者：Yang, R; Piperdi, S; Gorlick, R,期刊：Clinical Cancer Research, 页码：6396-6404 , 文章类型： Article，,卷期：2008年14-20]
- Purpose: Chelerythrine, a widely used broad-range protein kinase C inhibitor, induces apoptosis in many cell types. In this study, the mechanism of chelerythrine-induced apoptosis in osteosarcoma was investigated.Experim...
- The Desmoplastic Reaction Surrounding Hepatic Colorectal Adenocarcinoma Metastases Aids Tumor Growth and Survival via alpha(v) Integrin Ligation
[作者：Conti, JA; Kendall, TJ; Bateman, A; Armstrong, TA; Papa-Adams, A; Xu, Q; Packham, G; Primrose, JN; Benyon, RC; Iredale, JP,期刊：Clinical Cancer Research, 页码：6405-6413 , 文章类型： Article，,卷期：2008年14-20]
- Purpose: The treatment of metastatic colorectal carcinoma represents a major clinical challenge. We investigated the hypothesis that the desmoplastic reaction within the liver elicited by metastatic adenocarcinoma, chara...
- Derlin-1 Is Overexpressed on theTumor Cell Surface and Enables Antibody-Mediated Tumor Targeting Therapy
[作者：Ran, YL; Hu, H; Hu, D; Zhou, ZA; Sun, YM; Yu, L; Sun, LX; Pan, J; Liu, J; Liu, T; Yang, ZH,期刊：Clinical Cancer Research, 页码：6538-6545 , 文章类型： Article，,卷期：2008年14-20]
- Purpose: Tumor targeting therapy is one of the most promising strategies for anticancer treatment. Derlin-1 has been reported to participate in misfolded protein dislocation and integrates into the endoplasmic reticulum ...
- DNA Double-Strand Break Repair of Blood Lymphocytes and Normal Tissues Analysed in a Preclinical Mouse Model: Implications for Radiosensitivity Testing
[作者：Rube, CE; Grudzenski, S; Kuhne, M; Dong, XR; Rief, N; Loebrich, M; Rube, C,期刊：Clinical Cancer Research, 页码：6546-6555 , 文章类型： Article，,卷期：2008年14-20]
- Purpose: Radiotherapy is an effective cancer treatment, but a few patients suffer severe radiation toxicities in neighboring normal tissues. There is increasing evidence that the variable susceptibility to radiation toxi...
- The Wnt-5a-Derived Hexapeptide Foxy-5 Inhibits Breast Cancer Metastasis In vivo by Targeting Cell Motility
[作者：Safholm, A; Tuomela, J; Rosenkvist, J; Dejmek, J; Harkonen, P; Andersson, T,期刊：Clinical Cancer Research, 页码：6556-6563 , 文章类型： Article，,卷期：2008年14-20]
- Purpose: An inherent problem in breast cancer treatment is that current therapeutic approaches fail to specifically target the dissemination of breast cancer cells from the primary tumor. Clinical findings show that the ...
- New Two-Photon Activated Photodynamic Therapy Sensitizers Induce Xenograft Tumor Regressions after Near-IR Laser Treatment through the Body of the Host Mouse
[作者：Starkey, JR; Rebane, AK; Drobizhev, MA; Meng, FQ; Gong, AJ; Elliott, A; McInnerney, K; Spangler, CW,期刊：Clinical Cancer Research, 页码：6564-6573 , 文章类型： Article，,卷期：2008年14-20]
- Purpose: The aim of this study was to show that novel photodynamic therapy (PDT) sensitizers can be activated by two-photon absorption in the near-IR region of the spectrum and to show, for the first time, that such acti...
- Early Changes in Functional Dynamic Magnetic Resonance Imaging Predict for Pathologic Response to Neoadjuvant Chemotherapy in Primary Breast Cancer
[作者：Ah-See, MLW; Makris, A; Taylor, NJ; Harrison, M; Richman, PI; Burcombe, RJ; Stirling, JJ; d'Arcy, JA; Collins, DJ; Pittam, MR; Ravichandran, D; Padhani, AR,期刊：Clinical Cancer Research, 页码：6580-6589 , 文章类型： Article，,卷期：2008年14-20]
- Purpose: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) allows non-invasive, in vivo measurements of tissue microvessel perfusion and permeability. We examined whether DCE-MRI done after two cycles of neo...
- Subclassification and Individual Survival Time Prediction from Gene Expression Data of Neuroblastoma Patients by Using CASPAR
[作者：Oberthuer, A; Kaderali, L; Kahlert, Y; Hero, B; Westermann, F; Berthold, F; Brors, B; Eils, R; Fischer, M,期刊：Clinical Cancer Research, 页码：6590-6601 , 文章类型： Article，,卷期：2008年14-20]
- Purpose: To predict individual survival times for neuroblastoma patients from gene expression data using the cancer survival prediction using automatic relevance determination (CASPAR) algorithm.Experimental Design: A fi...
- Chemosensitivity and Stratification by a Five Monoclonal Antibody Immunohistochemistry Test in the NSABP B14 and B20 Trials
[作者：Ross, DT; Kim, CY; Tang, G; Bohn, OL; Beck, RA; Ring, BZ; Seitz, RS; Paik, S; Costantino, JP; Wolmark, N,期刊：Clinical Cancer Research, 页码：6602-6609 , 文章类型： Article，,卷期：2008年14-20]
- Purpose: To test the association between risk stratification and outcome in a prospectively designed, blinded retrospective study using tissue arrays of available paraffin blocks from the estrogen receptor-expressing, no...
- Cyclin D1-Specific Cytotoxic T Lymphocytes Are Present in the Repertoire of Cancer Patients: Implications for Cancer Immunotherapy
[作者：Kondo, E; Maecker, B; Weihrauch, MR; Wickenhauser, C; Zeng, WY; Nadler, LM; Schultze, JL; von Bergwelt-Baildon, MS,期刊：Clinical Cancer Research, 页码：6574-6579 , 文章类型： Article，,卷期：2008年14-20]
- Purpose: Cyclin D1, a key cell cycle regulator, is overexpressed in multiple types of cancer. Such tumor-associated genes may be useful targets for cancer immunotherapy. Nevertheless, it had previously been suggested tha...
- Mucosa-Associated Lymphoid Tissue Lymphoma: Novel Translocations Including Rearrangements of ODZ2, JMJD2C, and CNN3
[作者：Vinatzer, U; Gollinger, M; Muellauer, L; Raderer, M; Chott, A; Streubel, B,期刊：Clinical Cancer Research, 页码：6426-6431 , 文章类型： Article，,卷期：2008年14-20]
- Purpose: The well-known translocations identified in MALT lymphomas include t(11;18)/AP12-MALT1, t(1;14)/IGH-BCL10, and t(14;18)/IGH-MALT1. Molecular investigations have suggested that these three disparate translocation...
- Antiapoptotic Activity of Autocrine Mterleukin-22 and Therapeutic Effects of Interleukin-22-Small Interfering RNA on Human Lung Cancer Xenografts
[作者：Zhang, WC; Chen, YY; Wei, HM; Zheng, CG; Sun, R; Zhang, J; Tian, ZG,期刊：Clinical Cancer Research, 页码：6432-6439 , 文章类型： Article，,卷期：2008年14-20]
- Purpose: Non-small cell lung carcinoma (NSCLC) is one of most common malignant diseases and usually is resistant against apoptosis-inducing chemotherapy. This study is to explore the antiapoptotic mechanisms of interleuk...
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