- Acquired Resistance to Small Molecule ErbB2 Tyrosine Kinase Inhibitors
[作者:Chen, FL; Xia, WL; Spector, NL,期刊:Clinical Cancer Research, 页码:6730-6734 , 文章类型: Article,,卷期:2008年14-21]
- Breast cancers overexpressing the ErbB2 (HER2) receptor tyrosine kinase oncogene are treated with targeted therapies such as trastuzumab (Herceptin), an anti-ErbB2 antibody, and lapatinib (GW572016/Tykerb), a selective s...
- The Interleukin-8 Pathway in Cancer
[作者:Waugh, DJJ; Wilson, C,期刊:Clinical Cancer Research, 页码:6735-6741 , 文章类型: Article,,卷期:2008年14-21]
- Interleukin-8 (IL-8) is a proinflammatory CXC chemokine associated with the promotion of neutrophil chemotaxis and degranulation. This chemokine activates multiple intracellular signaling pathways downstream of two cell-...
- CD44 is of Functional Importance for Colorectal Cancer Stem Cells
[作者:Du, L; Wang, HY; He, LY; Zhang, JY; Ni, BY; Wang, XH; Jin, HJ; Cahuzac, N; Mehrpour, M; Lu, YY; Chen, Q,期刊:Clinical Cancer Research, 页码:6751-6760 , 文章类型: Article,,卷期:2008年14-21]
- Purpose: Both CD44 and CD133 were reported as putative markers for isolating colorectal cancer stem cells (CSC). It remains to be resolved if both of these markers are of functional importance for colorectal CSC.Experime...
- Targeting the P13K p110 alpha Isoform Inhibits Medulloblastoma Proliferation, Chemoresistance, and Migration
[作者:Guerreiro, AS; Fattet, S; Fischer, B; Shalaby, T; Jackson, SP; Schoenwaelder, SM; Grotzer, MA; Delattre, O; Arcaro, A,期刊:Clinical Cancer Research, 页码:6761-6769 , 文章类型: Article,,卷期:2008年14-21]
- Purpose: The phosphoinositide 3-kinase (PI3K)/Akt pathway is frequently activated in human cancer and plays a crucial role in medulloblastoma biology. We were interested in gaining further insight into the potential of t...
- Reciprocal CD4(+) T-Cell Balance of Effector CD62L(low) CD4(+) and CD62L(high) CD25(+) CD4(+) Regulatory T Cells in Small Cell Lung Cancer Reflects Disease Stage
[作者:Koyama, K; Kagamu, H; Miura, S; Hiura, T; Miyabayashi, T; Itoh, R; Kuriyama, H; Tanaka, H; Tanaka, J; Yoshizawa, H; Nakata, K; Gejyo, F,期刊:Clinical Cancer Research, 页码:6770-6779 , 文章类型: Article,,卷期:2008年14-21]
- Purpose: Small cell lung cancer (SCLC) possesses high tendency to disseminate. However, SCLC patients with paraneoplastic syndrome mediated by immunity against onconeural antigens remain in limited-stage disease (LD) wit...
- Identification of an Immunogenic CTL Epitope of HIFPH3 for Immunotherapy of Renal Cell Carcinoma
[作者:Sato, E; Torigoe, T; Hirohashi, Y; Kitamura, H; Tanaka, T; Honma, I; Asanuma, H; Harada, K; Takasu, H; Masumori, N; Ito, N; Hasegawa, T; Tsukamoto, T; Sato, N,期刊:Clinical Cancer Research, 页码:6916-6923 , 文章类型: Article,,卷期:2008年14-21]
- Purpose: CD8(+) CTLs have an essential role in immune response against tumor. Although tumor-associated antigens have been identified in renal cell carcinoma (RCC), few of these are commonly shared and investigated as th...
- Biobehavioral Influences on Matrix Metalloproteinase Expression in Ovarian Carcinoma
[作者:Lutgendorf, SK; Lamkin, DM; Jennings, NB; Arevalo, JMG; Penedo, F; DeGeest, K; Langley, RR; Lucci, JA; Cole, SW; Lubaroff, DM; Sood, AK,期刊:Clinical Cancer Research, 页码:6839-6846 , 文章类型: Article,,卷期:2008年14-21]
- Purpose: Stromal cells in the tumor microenvironment, such as macrophages, play an active role in tumor growth and angiogenesis. However, little is known about relationships of biobehavioral factors with angiogenic cytok...
- SCCRO (DCUN1D1) Induces Extracellular Matrix Invasion by Activating Matrix Metalloproteinase 2
[作者:O-charoenrat, P; Sarkaria, I; Talbot, SG; Reddy, P; Dao, S; Ngai, I; Shaha, A; Kraus, D; Shah, J; Rusch, V; Ramanathan, Y; Singh, B,期刊:Clinical Cancer Research, 页码:6780-6789 , 文章类型: Article,,卷期:2008年14-21]
- Purpose: Ectopic expression of squamous cell carcinoma-related oncogene (SCCRO or DCUN1D1) in NIH-3T3 cells induces invasion in vitro and produces highly invasive xenografts in nude mice with a propensity for regional ly...
- Ankyrin Repeat Domain 1, ANKRD1, a Novel Determinant of Cisplatin Sensitivity Expressed in Ovarian Cancer
[作者:Scurr, LL; Guminski, AD; Chiew, YE; Balleine, RL; Sharma, R; Lei, Y; Pryor, K; Wain, G; Brand, A; Byth, K; Kennedy, C; Rizos, H; Harnett, PR; deFazio, A,期刊:Clinical Cancer Research, 页码:6924-6932 , 文章类型: Article,,卷期:2008年14-21]
- Purpose: The standard of care for ovarian cancer includes platinum-based chemotherapy. It is not possible, however, to predict clinical platinum sensitivity or to design rational strategies to overcome resistance. We use...
- Reduced Erlotinib Sensitivity of Epidermal Growth Factor Receptor-Mutant Non-Small Cell Lung Cancer following Cisplatin Exposure: A Cell Culture Model of Second-line Erlotinib Treatment
[作者:Chin, TM; Quinlan, MP; Singh, A; Sequist, LV; Lynch, TJ; Haber, DA; Sharma, SV; Settleman, J,期刊:Clinical Cancer Research, 页码:6867-6876 , 文章类型: Article,,卷期:2008年14-21]
- Purpose: Epidermal growth factor receptor (EGFR) kinase inhibitors induce dramatic clinical responses in a subset of non-small cell lung cancer (NSCLC) patients with advanced disease, and such responses are correlated wi...
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