- Vascular Endothelial Growth Factor C Stimulates Progression of Human Gastric Cancer via Both Autocrine and Paracrine Mechanisms
[作者:Kodama, M; Kitadai, Y; Tanaka, M; Kuwai, T; Tanaka, S; Oue, N; Yasui, W; Chayama, K,期刊:Clinical Cancer Research, 页码:7205-7214 , 文章类型: Article,,卷期:2008年14-22]
- Purpose: Vascular endothelial growth factor (VEGF)-C induces lymphangiogenesis by activating the VEGF receptor (VEGFR)-3, which is expressed by lymphatic endothelial cells. VEGFR-3 has also been detected on several malig...
- Identification of the Molecular Mechanisms for Dedifferentiation at the Invasion Front of Colorectal Cancer by a Gene Expression Analysis
[作者:Oku, Y; Shimoji, T; Takifuji, K; Hotta, T; Yokoyama, S; Matsuda, K; Higashiguchi, T; Tominaga, T; Nasu, T; Tamura, K; Matsuura, M; Miyata, S; Kato, Y; Yamaue, H; Miki, Y,期刊:Clinical Cancer Research, 页码:7215-7222 , 文章类型: Article,,卷期:2008年14-22]
- Purpose: The aim of this study is to identify gene expression signatures that accompany dedifferentiation at the cancer invasion front in colorectal cancer. Experimental Design: Two types of colorectal cancer were select...
- Nonclinical Antiangiogenesis and Antitumor Activities of Axitinib (AG-013736), an Oral, Potent, and Selective Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases 1, 2, 3
[作者:Hu-Lowe, DD; Zou, HY; Grazzini, ML; Hallin, ME; Wickman, GR; Amundson, K; Chen, JH; Rewolinski, DA; Yamazaki, S; Wu, EY; McTigue, MA; Murray, BW; Kania, RS; O'Connor, P; Shalinsky, DR; Bender, SL,期刊:Clinical Cancer Research, 页码:7272-7283 , 文章类型: Article,,卷期:2008年14-22]
- Purpose: Axitinib (AG-013736) is a potent and selective inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases 1 to 3 that is in clinical development for the treatment of solid tumors. We provid...
- Endosialin Protein Expression and Therapeutic Target Potential in Human Solid Tumors: Sarcoma versus Carcinoma
[作者:Rouleau, C; Curiel, M; Weber, W; Smale, R; Kurtzberg, L; Mascarello, J; Berger, C; Wallar, G; Bagley, R; Honma, N; Hasegawa, K; Ishida, I; Kataoka, S; Thurberg, BL; Mehraein, K; Horten, B; Miller, G; Teicher, BA,期刊:Clinical Cancer Research, 页码:7223-7236 , 文章类型: Article,,卷期:2008年14-22]
- Purpose: Endosialin/CD248/tumor endothelial marker 1 is expressed in stromal cells, endothelial cells, and pericytes in various tumors; however, few studies have focused on expression in malignant cells.Experimental Desi...
- Loss of Histone H4K20 Trimethylation Occurs in Preneoplasia and Influences Prognosis of Non-Small Cell Lung Cancer
[作者:Van Den Broeck, A; Brambilla, E; Moro-Sibilot, D; Lantuejoul, S; Brambilla, C; Eymin, B; Khochbin, S; Gazzeri, S,期刊:Clinical Cancer Research, 页码:7237-7245 , 文章类型: Article,,卷期:2008年14-22]
- Purpose: Epigenetic modifications of histone have crucial roles in the control of gene activity, nuclear architecture, and genomic stability. In this respect, they may contribute to the development and progression of can...
- Ovarian Cancer Early Detection Claims Are Biased
[作者:McIntosh, M; Anderson, G; Drescher, C; Hanash, S; Urban, N; Brown, P; Gambhir, SS; Coukos, G; Laird, PW; Nelson, B; Palmer, C,期刊:Clinical Cancer Research, 页码:7574-7574 , 文章类型: Letter,,卷期:2008年14-22]
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- Leukemia-Associated Antigens Are Critical for the Proliferation of Acute Myeloid Leukemia Cells
[作者:Greiner, J; Bullinger, L; Guinn, BA; Dohner, H; Schmitt, M,期刊:Clinical Cancer Research, 页码:7161-7166 , 文章类型: Article,,卷期:2008年14-22]
- Acute myeloid leukemia (AML) is the most common acute leukemia in adults. With intensive induction therapy, most patients younger than 60 years achieve complete remission. However, even if these younger patients were tre...
- Overexpression of Indoleamine 2,3-Dioxygenase in Human Endometrial Carcinoma Cells Induces Rapid Tumor Growth in a Mouse Xenograft Model
[作者:Yoshida, N; Ino, K; Ishida, Y; Kajiyama, H; Yamamoto, E; Shibata, K; Terauchi, M; Nawa, A; Akimoto, H; Takikawa, O; Isobe, K; Kikkawa, F,期刊:Clinical Cancer Research, 页码:7251-7259 , 文章类型: Article,,卷期:2008年14-22]
- Purpose: Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme that induces immune tolerance in mice. Our prior study showed that high tumoral IDO expression in endometrial cancer tissues correlates with ...
- Human Telomerase Reverse Transcriptase Activated by E6 Oncoprotein Is Required for Human Papillomavirus-16/18-Infected Lung Tumorigenesis
[作者:Cheng, YW; Wu, TC; Chen, CY; Chou, MC; Ko, JL; Lee, H,期刊:Clinical Cancer Research, 页码:7173-7179 , 文章类型: Article,,卷期:2008年14-22]
- Purpose: Our recent report indicates that human papillomavirus (HPV)-16/18 E6 oncoprotein is expressed in lung tumors and is related to p53 inactivation. We further explored whether human telomerase reverse transcriptase...
- Clonal Evolution in t(14;18)-Positive Follicular Lymphoma, Evidence for Multiple Common Pathways, and Frequent Parallel Clonal Evolution
[作者:d'Amore, F; Chan, E; Iqbal, J; Geng, HM; Young, K; Xiao, L; Hess, MM; Sanger, WG; Smith, L; Wiuf, C; Hagberg, O; Fu, K; Chan, WC; Dave, BJ,期刊:Clinical Cancer Research, 页码:7180-7187 , 文章类型: Article,,卷期:2008年14-22]
- Purpose: Follicular lymphoma typically has acquired a t(14;18) translocation, but subsequent additional cytogenetic abnormalities contribute to disease progression. The main aims of the study are to (a) identify the freq...
- Irinophore C, a Novel Nanoformulation of Irinotecan, Alters Tumor Vascular Function and Enhances the Distribution of 5-Fluorouracil and Doxorubicin
[作者:Baker, JHE; Lam, J; Kyle, AH; Sy, J; Oliver, T; Co, SJ; Dragowska, WH; Ramsay, E; Anantha, M; Ruth, TJ; Adam, MJ; Yung, A; Kozlowski, P; Minchinton, AI; Ng, SSW; Bally, MB; Yapp, DTT,期刊:Clinical Cancer Research, 页码:7260-7271 , 文章类型: Article,,卷期:2008年14-22]
- Purpose: To examine the antitumor effects of Irinophore C, a nanopharmaceutical formulation of irinotecan, on the tissue morphology and function of tumor vasculature in HT-29 human colorectal tumors.Experimental Design: ...
- Surgery followed by Persistence of High-Grade Squamous Intraepithelial Lesions Is Associated with the Induction of a Dysfunctional HPV16-Specific T-Cell Response
[作者:van Steenwijk, PJD; Piersma, SJ; Welters, MJP; van der Hulst, JM; Fleuren, G; Hellebrekers, BWJ; Kenter, GG; van der Burg, SH,期刊:Clinical Cancer Research, 页码:7188-7195 , 文章类型: Article,,卷期:2008年14-22]
- Purpose: To characterize HPV16 E6- and E7-specific T-cell immunity inpatients with high-grade squamous intraepithelial lesions (HSIL).Experimental Design: Peripheral blood mononuclear cells isolated from 38 patients with...
- Role of the Erythropoietin Receptor in ETV6/RUNX1-Positive Acute Lymphoblastic Leukemia
[作者:Inthal, A; Krapf, G; Beck, D; Joas, R; Kauer, MO; Orel, L; Fuka, G; Mann, G; Panzer-Grumayer, ER,期刊:Clinical Cancer Research, 页码:7196-7204 , 文章类型: Article,,卷期:2008年14-22]
- Purpose: We explored the mechanisms leading to the distinct overexpression of EPOR as well as the effects of EPO signaling on ETV6/RUNX1-positive acute lymphoblastic leukemias.Experimental Design: ETV6/RUNX1-expressing m...
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