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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共50条记录   Centromere-Associated Protein E: A Motor That Puts the Brakes on the Mitotic Checkpoint [作者：Wood, KW; Chua, P; Sutton, D; Jackson, JR,期刊：Clinical Cancer Research, 页码：7588-7592 , 文章类型： Article，,卷期：2008年14-23] Cell cycle checkpoints have long been recognized as important nodes for regulating cell proliferation and maintaining genomic integrity. These checkpoints are often altered in cancer and represent promising points for th... Cancer-Related Axonogenesis and Neurogenesis in Prostate Cancer [作者：Ayala, GE; Dai, H; Powell, M; Li, R; Ding, Y; Wheeler, TM; Shine, D; Kadmon, D; Thompson, T; Miles, BJ; Ittmann, MM; Rowley, D,期刊：Clinical Cancer Research, 页码：7593-7603 , 文章类型： Article，,卷期：2008年14-23] Purpose: Perineural invasion is the only interaction between cancer cells and nerves studied to date. It is a symbiotic relationship between cancer and nerves that results in growth advantage for both. In this article, w... The Challenge of Herbal Therapies for Prostate Cancer [作者：Bhatt, RS; Bubley, GJ,期刊：Clinical Cancer Research, 页码：7581-7582 , 文章类型： Article，,卷期：2008年14-23] The paper by Singh et al. shows that silibinin inhibits prostate cancer growth in the TRAMP mouse model. Among its other properties, silibinin inhibits the progression of prostate cancer by decreasing angiogenesis and tu... Targeting the Kinesin Spindle Protein: Basic Principles and Clinical Implications [作者：Sarli, V; Giannis, A,期刊：Clinical Cancer Research, 页码：7583-7587 , 文章类型： Article，,卷期：2008年14-23] Kinesin spindle protein (KSP), a member of the kinesin superfamily of microtubule-based motors, plays a critical role in mitosis as it mediates centrosome separation and bipolar spindle assembly and maintenance. Inhibiti... Constitutive Activation of Signal Transducer and Activator of Transcription 5 Contributes to Tumor Growth, Epithelial-Mesenchymal Transition, and Resistance to Epidermal Growth Factor Receptor Targeting [作者：Koppikar, P; Lui, VWY; Man, D; Xi, S; Chai, RL; Nelson, E; Tobey, ABJ; Grandis, JR,期刊：Clinical Cancer Research, 页码：7682-7690 , 文章类型： Article，,卷期：2008年14-23] Purpose: Signal transducer and activator of transcription 5 (STAT5) is activated in squamous cell carcinoma of the head and neck (SCCHN), where targeting of STAT5 inhibits tumor growth in vitro and in vivo. The role of S... Cannabinoid Receptor Activation Induces Apoptosis through Tumor Necrosis Factor alpha - Mediated Ceramide De novo Synthesis in Colon Cancer Cells [作者：Cianchi, F; Papucci, L; Schiavone, N; Lulli, M; Magnelli, L; Vinci, MC; Messerini, L; Manera, C; Ronconi, E; Romagnani, P; Donnini, M; Perigli, G; Trallori, G; Tanganelli, E; Capaccioli, S; Masini, E,期刊：Clinical Cancer Research, 页码：7691-7700 , 文章类型： Article，,卷期：2008年14-23] Purpose: Cannabinoids have been recently proposed as a new family of potential antitumor agents. The present study was undertaken to investigate the expression of the two cannabinoid receptors, CB1 and CB2, in colorectal... Molecularly Targeted Radiosensitization of Human Prostate Cancer by Modulating Inhibitor of Apoptosis [作者：Dai, Y; Liu, M; Tang, W; DeSano, J; Burstein, E; Davis, M; Pienta, K; Lawrence, T; Xu, L,期刊：Clinical Cancer Research, 页码：7701-7710 , 文章类型： Article，,卷期：2008年14-23] Purpose: The inhibitor of apoptosis proteins (IAP) are overexpressed in hormone-refractory prostate cancer, rendering the cancer cells resistant to radiation. This study aims to investigate the radiosensitizing effect of... Combination Immunotherapy for Tumors via Sequential Intratumoral Injections of Oncolytic Herpes Simplex Virus 1 and Immature Dendritic Cells [作者：Farrell, CJ; Zaupa, C; Barnard, Z; Maley, J; Martuza, RL; Rabkin, SD; Curry, WT,期刊：Clinical Cancer Research, 页码：7711-7716 , 文章类型： Article，,卷期：2008年14-23] Purpose: Oncolytic herpes simplex virus 1 (oHSV) vectors treat tumors in preclinical models and have been used safely in phase I clinical trials for patients with cancer. Infection of tumors with oHSV also induces specif... Targeted Inhibition of Cyclic AMP Phosphodiesterase-4 Promotes Brain Tumor Regression [作者：Goldhoff, P; Warrington, NM; Limbrick, DD; Hope, A; Woerner, BM; Jackson, E; Perry, A; Piwnica-Worms, D; Rubin, JB,期刊：Clinical Cancer Research, 页码：7717-7725 , 文章类型： Article，,卷期：2008年14-23] Purpose: As favorable outcomes from malignant brain tumors remain limited by poor survival and treatment-related toxicity, novel approaches to cure are essential. Previously, we identified the cyclic AMP phosphodiesteras... Imatinib Targeting of KIT-Mutant Oncoprotein in Melanoma [作者：Jiang, XF; Zhou, J; Yuen, NK; Corless, CL; Heinrich, MC; Fletcher, JA; Demetri, GD; Widlund, HR; Fisher, DE; Hodi, FS,期刊：Clinical Cancer Research, 页码：7726-7732 , 文章类型： Article，,卷期：2008年14-23] Purpose: Melanoma subtypes based on anatomic location and UV light exposure can be further classified based on genetic alterations recently identified. Mutations and gene amplification in KIT have been described in a sig... Cooperation of the Agonistic DR5 Antibody Apomab with Chemotherapy to Inhibit Orthotopic Lung Tumor Growth and Improve Survival [作者：Jin, HK; Yang, RH; Ross, J; Fong, S; Carano, R; Totpal, K; Lawrence, D; Zheng, Z; Koeppen, H; Stern, H; Schwall, R; Ashkenazi, A,期刊：Clinical Cancer Research, 页码：7733-7740 , 文章类型： Article，,卷期：2008年14-23] Purpose: Apomab is a fully human monoclonal antibody that induces programmed cell death through the proapoptotic receptor DR5 in various cancer cells but not in normal cells. Several lung cancer cell lines express DR5 an... Epigenetic Inactivation of Galanin Receptor 1 in Head and Neck Cancer [作者：Misawa, K; Ueda, Y; Kanazawa, T; Misawa, Y; Jang, I; Brenner, JC; Ogawa, T; Takebayashi, S; Grenman, R; Herman, JG; Mineta, H; Carey, TE,期刊：Clinical Cancer Research, 页码：7604-7613 , 文章类型： Article，,卷期：2008年14-23] Purpose: One copy of the galanin receptor 1 (GALR1) locus on 18q is often deleted and expression is absent in some head and neck squamous cell carcinoma (HNSCC) cell lines. To determine if loss of heterozygosity and hype... 14-3-3 sigma Modulates Pancreatic Cancer Cell Survival and Invasiveness [作者：Neupane, D; Korc, M,期刊：Clinical Cancer Research, 页码：7614-7623 , 文章类型： Article，,卷期：2008年14-23] Purpose: The purpose of the present study was to investigate the potential role of 14-3-3 sigma in pancreatic ductal adenocarcinoma (PDAC).Experimental Design: 14-3-3 isoform expression was determined by real-time quanti... Claudin-18 Splice Variant 2 Is a Pan-Cancer Target Suitable for Therapeutic Antibody Development [作者：Sahin, U; Koslowski, M; Dhaene, K; Usener, D; Brandenburg, G; Seitz, G; Huber, C; Tureci, O,期刊：Clinical Cancer Research, 页码：7624-7634 , 文章类型： Article，,卷期：2008年14-23] Purpose: Antibody-based cancer therapies have emerged as the most promising therapeutics in oncology. The purpose of this study was to discover novel targets for therapeutic antibodies in solid cancer.Experimental Design... Perilobar Nephrogenic Rests Are Nonobligate Molecular Genetic Precursor Lesions of Insulin-Like Growth Factor-II-Associated Wilms Tumors [作者：Vuononvirta, R; Sebire, NJ; Dallosso, AR; Reis, JS; Williams, RD; Mackay, A; Fenwick, K; Grigoriadis, A; Ashworth, A; Pritchard-Jones, K; Brown, KW; Vujanic, GM; Jones, C,期刊：Clinical Cancer Research, 页码：7635-7644 , 文章类型： Article，,卷期：2008年14-23] Purpose: Perilobar nephrogenic rests (PLNRs) are abnormally persistent foci of embryonal immature blastema that have been associated with dysregulation at the 11p15 locus by genetic/epigenetic means and are thought to be... Genome-Wide Loss of Heterozygosity and Uniparental Disomy in BRCA1/2-Associated Ovarian Carcinomas [作者：Walsh, CS; Ogawa, S; Scoles, DR; Miller, CW; Kawamata, N; Narod, SA; Koeffler, HP; Karlan, BY,期刊：Clinical Cancer Research, 页码：7645-7651 , 文章类型： Article，,卷期：2008年14-23] Purpose: The importance of the BRCA gene products in maintaining genomic stability led us to hypothesize that BRCA-associated and sporadic ovarian cancers would have distinctive genetic profiles despite similarities in h...