- Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma
[作者：Lu, KH; Wu, WG; Dave, B; Slomovitz, BM; Burke, TW; Munsell, MF; Broaddus, RR; Walker, CL,期刊：Clinical Cancer Research, 页码：2543-2550 , 文章类型： Article，,卷期：2008年14-9]
- Purpose: The involvement of phosphatase and tensin homologue deleted on chromosome ten (PTEN) in endometrial carcinoma has implicated phosphatidylinositol 3-kinase Signaling and mammalian target of rapamycin (mTOR) activ...
- Altered MicroRNA expression in cervical carcinomas
[作者：Lee, JW; Choi, CH; Choi, JJ; Park, YA; Kim, SJ; Hwang, SY; Kim, WY; Kim, TJ; Lee, JH; Kim, BG; Bae, DS,期刊：Clinical Cancer Research, 页码：2535-2542 , 文章类型： Article，,卷期：2008年14-9]
- Purpose: MicroRNAs (miRNA) are small noncoding RNAs that are 18 to 25 nucleotides in length; they regulate the stability or translational efficiency of target mRNAs. Emerging evidence suggests that miRNAs might be involv...
- Global and regional CpG methylation in pheochromocytomas and abdominal paragangliomas: Association to malignant behavior
[作者：Geli, J; Kiss, N; Karimi, M; Lee, JJ; Backdahl, M; Ekstrom, TJ; Larsson, C,期刊：Clinical Cancer Research, 页码：2551-2559 , 文章类型： Article，,卷期：2008年14-9]
- Purpose: This study aims to quantitatively assess promoter and global methylation changes in pheochromocytomas and abdominal paragangliomas and its relation to tumor phenotypes.Experimental Design: A panel of 53 primary ...
- Secreted CXCL1 is a potential mediator and marker of the tumor invasion of bladder cancer
[作者：Kawanishi, H; Matsui, Y; Ito, M; Watanabe, J; Takahashi, T; Nishizawa, K; Nishiyama, H; Kamoto, T; Mikami, Y; Tanaka, Y; Jung, G; Akiyama, H; Nobumasa, H; Guilford, P; Reeve, A; Okuno, Y; Tsujimoto, G; Nakamura, E; Ogawa, O,期刊：Clinical Cancer Research, 页码：2579-2587 , 文章类型： Article，,卷期：2008年14-9]
- Purpose: The purpose of this study was to identify proteins that are potentially involved in the tumor invasion of bladder cancer.Experimental Design: We searched for the candidate proteins by comparing the profiles of s...
- Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue
[作者：Wong, TS; Liu, XB; Wong, BYH; Ng, RWM; Yuen, APW; Wei, WI,期刊：Clinical Cancer Research, 页码：2588-2592 , 文章类型： Article，,卷期：2008年14-9]
- Purpose: The aim of this study was to evaluate the micro RNA expression patterns in squamous cell carcinoma (SCC) of the tongue.Experimental Design: Expression levels of 156 human mature microRNAs were examined using rea...
- The bone marrow microenvironment as a tumor sanctuary and contributor to drug resistance
[作者：Meads, MB; Hazlehurst, LA; Dalton, WS,期刊：Clinical Cancer Research, 页码：2519-2526 , 文章类型： Article，,卷期：2008年14-9]
- The bone marrow microenvironment facilitates the survival, differentiation, and proliferation of hematopoietic cells. These cells are supported by fibroblast-like bone marrow stromal cells, osteoblasts, and osteoclasts w...
- Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma
[作者：Suehiro, Y; Wong, CW; Chirieac, LR; Kondo, Y; Shen, L; Webb, CR; Chan, YW; Chan, ASY; Chan, TL; Wu, TT; Rashid, A; Hamanaka, Y; Hinoda, Y; Shannon, RL; Wang, XM; Morris, J; Issa, JPJ; Yuen, ST; Leung, SY; Hamilton, SR,期刊：Clinical Cancer Research, 页码：2560-2569 , 文章类型： Article，,卷期：2008年14-9]
- Purpose: Early events in colorectal tumorigenesis include mutation of the adenomatous polyposis coli (APC) gene and epigenetic hypermethylation with transcriptional silencing of the O-6-methylguanine DNA methyltransferas...
- Prognostic value of the molecular detection of circulating tumor cells using a multimarker reverse transcription-PCR assay for cytokeratin 19, mammaglobin A, and HER2 in early breast cancer
[作者：Ignatiadis, M; Kallergi, G; Ntoulia, M; Perraki, M; Apostolaki, S; Kafousi, M; Chlouverakis, G; Stathopoulos, E; Lianidou, E; Georgoulias, V; Mavroudis, D,期刊：Clinical Cancer Research, 页码：2593-2600 , 文章类型： Article，,卷期：2008年14-9]
- Purpose: To investigate the prognostic value of the molecular detection of circulating tumor cells (CTCs) using three markers [cytokeratin 19 (CK19), mammaglobin A (MGB1), and HER2] in early breast cancer.Experimental De...
- High-resolution array-based comparative genomic hybridization of bladder cancers identifies mouse double minute 4 (MDM4) as an amplification target exclusive of MDM2 and TP53
[作者：Veerakumarasivam, A; Scott, HE; Chin, SF; Warren, A; Wallard, MJ; Grimmer, D; Ichimura, K; Caldas, C; Collins, VP; Neal, DE; Kelly, JD,期刊：Clinical Cancer Research, 页码：2527-2534 , 文章类型： Article，,卷期：2008年14-9]
- Purpose: Loss of p53 function in urothelial cell carcinoma (UCC) by mutation or inactivation disrupts normal cell cycle checkpoints, generating a favorable milieu for genomic instability, a hallmark of UCC. The aim of th...
- A five-gene molecular grade index and HOXB13 : IL17BR are complementary prognostic factors in early stage breast cancer
[作者：Ma, XJ; Salunga, R; Dahiya, S; Wang, W; Carney, E; Durbecq, V; Harris, A; Goss, P; Sotiriou, C; Erlander, M; Sgroi, D,期刊：Clinical Cancer Research, 页码：2601-2608 , 文章类型： Article，,卷期：2008年14-9]
- Purpose: Histologic tumor grade is a well-established prognostic factor for breast cancer, and tumor grade - associated genes are the common denominator of many prognostic gene signatures. The objectives of this study ar...
- The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of ixabepilone: A first in class epothilone B analogue in late-phase clinical development
[作者：Goel, S; Cohen, M; Comezoglu, SN; Perrin, L; Andre, F; Jayabalan, D; Lacono, L; Comprelli, A; Ly, VT; Zhang, D; Xu, C; Humphreys, WG; McDaid, H; Goldberg, G; Horwitz, SB; Mani, S,期刊：Clinical Cancer Research, 页码：2701-2709 , 文章类型： Article，,卷期：2008年14-9]
- Purpose: To determine if ixabepilone is a substrate for cytochrome P450 3A4 (CYP3A4) and if its metabolism by this cytochrome is clinically important, we did a clinical drug interaction study in humans using ketoconazole...
- A phase I study of the safety and pharmacokinetics of the combination of pertuzumab (rhuMab 2C4) and capecitabine in patients with advanced solid tumors
[作者：Albanell, J; Montagut, C; Jones, ET; Pronk, L; Mellado, B; Beech, J; Gascon, P; Zugmaier, G; Brewster, M; Saunders, MP; Valle, JW,期刊：Clinical Cancer Research, 页码：2726-2731 , 文章类型： Article，,卷期：2008年14-9]
- Purpose: To study the safety, pharmacokinetics, and recommended dose of the combination of pertuzumab, a humanized monoclonal antibody HER2-dimerization inhibitor, and capecitabine in patients with advanced malignancies....
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