- Phase I clinical and pharmacokinetic study of plitidepsin as a 1-hour weekly intravenous infusion in patients with advanced solid tumors
[作者：Izquierdo, MA; Bowman, A; Garcia, M; Jodrell, D; Martinez, M; Pardo, B; Gomez, J; Lopez-Martin, JA; Jimeno, J; Germa, JR; Smyth, JF,期刊：Clinical Cancer Research, 页码：3105-3112 , 文章类型： Article，,卷期：2008年14-10]
- Purpose: Plitidepsin, given as a 1-hour weekly i.v. infusion for 3 consecutive weeks during a 4-week treatment cycle, was investigated in patients with solid tumors to determine the maximum tolerated dose and the recomme...
- Loss of heterozygosity at the BRCA2 locus detected by multiplex ligation-dependent probe amplification is common in prostate cancers from men with a germline BRCA2 mutation
[作者：Willems, AJ; Dawson, SJ; Samaratunga, H; De Luca, A; Anti, YC; Hopper, JL; Thorne, HJ,期刊：Clinical Cancer Research, 页码：2953-2961 , 文章类型： Article，,卷期：2008年14-10]
- Purpose: Prostate cancer risk is increased for men carrying a pathogenic germline mutation in BRCA2, and perhaps BRCA1. Our primary aim was to test for loss of heterozygosity (LOH) at the locus of the mutation in prostat...
- Critical role of Notch signaling in osteosarcoma invasion and metastasis
[作者：Zhang, PY; Yang, YW; Zweidler-McKay, PA; Hughes, DPM,期刊：Clinical Cancer Research, 页码：2962-2969 , 文章类型： Article，,卷期：2008年14-10]
- Purpose: Notch signaling is an important mediator of growth and survival in several cancer types, with Notch pathway genes functioning as oncogenes or tumor suppressors in different cancers. However, the role of Notch in...
- Helicobacter pylori augments growth of gastric cancers via the lipopolysaccharide-toll-like receptor 4 pathway whereas its lipopolysaccharide attenuates antitumor activities of human mononuclear cells
[作者：Chochi, K; Ichikura, T; Kinoshita, M; Majima, T; Shinomiya, N; Tsujimoto, H; Kawabata, T; Sugasawa, H; Ono, S; Seki, S; Mochizuki, H,期刊：Clinical Cancer Research, 页码：2909-2917 , 文章类型： Article，,卷期：2008年14-10]
- Purpose: Helicobacter pylori is reportedly involved in the development of gastric cancer. We investigated the mechanisms by which H. pylori affects gastric cancer growth and antitumor immunities in the host, focusing on ...
- Imaging bone and soft tissue tumors with the proliferation marker [F-18]fluorodeoxythymidine
[作者：Buck, AK; Herrmann, K; zum Bueschenfelde, CM; Juweid, ME; Bischoff, M; Glatting, G; Weirich, G; Moller, P; Wester, HJ; Scheidhauer, K; Dechow, T; Peschel, C; Schwaiger, M; Reske, SN,期刊：Clinical Cancer Research, 页码：2970-2977 , 文章类型： Article，,卷期：2008年14-10]
- Purpose: We have determined the ability of positron emission tomography (PET) with the thymidine analogue 3'-deoxy-3'[F-18]fluorothymidine (FLT) to detect manifestation sites of bone and soft tissue tumors, to assess tum...
- Novel glioblastoma markers with diagnostic and prognostic value identified through transcriptome analysis
[作者：Reddy, SP; Britto, R; Vinnakota, K; Aparna, H; Sreepathi, HK; Thota, B; Kumari, A; Shilpa, BM; Vrinda, M; Umesh, S; Samuel, C; Shetty, M; Tandon, A; Pandey, P; Hegde, S; Hegde, AS; Balasubramaniam, A; Chandramouli, BA; Santosh, V; Kondaiah, P; Somasundaram, K; Rao, MRS,期刊：Clinical Cancer Research, 页码：2978-2987 , 文章类型： Article，,卷期：2008年14-10]
- Purpose: Current methods of classification of astrocytoma based on histopathologic methods are often subjective and less accurate. Although patients with glioblastoma have grave prognosis, significant variability in pati...
- Epigenetic silencing of the tetraspanin CD9 during disease progression in multiple myeloma cells and correlation with survival
[作者：De Bruyne, E; Bos, TJ; Asosingh, K; Broek, IV; Menu, E; Van Valckenborgh, E; Atadja, P; Coiteux, V; Leleu, X; Thielemans, K; Van Camp, B; Vanderkerken, K; Van Riet, I,期刊：Clinical Cancer Research, 页码：2918-2926 , 文章类型： Article，,卷期：2008年14-10]
- Purpose: The purpose of this study was to investigate expression and epigenetic regulation of CD9 in multiple myeloma (MM) cells during disease progression.Experimental Design: CD9 expression was retrospectively analyzed...
- Analysis of the MammaPrint breast cancer assay in a predominantly postmenopausal cohort
[作者：Witmer, BS; Sgroi, DC; Ryan, PD; Bruinsma, TJ; Glas, AM; Male, A; Dahiya, S; Habin, K; Bernards, R; Haber, DA; Van't Veer, LJ; Ramaswamy, S,期刊：Clinical Cancer Research, 页码：2988-2993 , 文章类型： Article，,卷期：2008年14-10]
- Purpose: Most node-negative breast cancer patients are older and postmenopausal and are increasingly being offered adjuvant chemotherapy despite their low overall risk of distant relapse. A molecular diagnostic test with...
- Detection of copy number alterations in metastatic melanoma by a DNA fluorescence in situ hybridization probe panel and array comparative genomic hybridization: A Southwest Oncology Group study (S9431)
[作者：Moore, SR; Persons, DL; Sosman, JA; Bobadilla, D; Bedell, V; Smith, DD; Wolman, SR; Tuthill, RJ; Moon, J; Sondak, VK; Slovak, ML,期刊：Clinical Cancer Research, 页码：2927-2935 , 文章类型： Article，,卷期：2008年14-10]
- Purpose: Gene copy number alteration (CNA) is common in malignant melanoma and is associated with tumor development and progression. The concordance between molecular cytogenetic techniques used to determine CNA has not ...
- Divergent effects of castration on prostate cancer in TRAMP mice: Possible implications for therapy
[作者：Tang, Y; Wang, LB; Goloubeva, O; Khan, MA; Zhang, B; Hussain, A,期刊：Clinical Cancer Research, 页码：2936-2943 , 文章类型： Article，,卷期：2008年14-10]
- Purpose: Divergent responses to androgen deprivation have been found in patients and in animal models of prostate cancer. The molecular basis for these different outcomes is unknown. Our aim was to identify the molecular...
- Translocations involving the immunoglobulin heavy chain gene locus predict better survival in gastric diffuse large B-cell lymphoma
[作者：Nakamura, S; Ye, H; Bacon, CM; Goatly, A; Liu, HX; Kerr, L; Banham, AH; Streubel, B; Yao, T; Tsuneyoshi, M; Savio, A; Takeshita, M; Dartigues, P; Ruskone-Fourmestraux, A; Matsumoto, T; Iida, M; Du, MQ,期刊：Clinical Cancer Research, 页码：3002-3010 , 文章类型： Article，,卷期：2008年14-10]
- Purpose: The pathogenesis and clinical heterogeneity of gastric diffuse large B-cell lymphoma (DLBCL) are poorly understood. We have comprehensively investigated the incidence and clinical significance of lymphoma-associ...
- Gene expression profiles associated with the presence of a fibrotic focus and the growth pattern in lymph node-negative breast cancer
[作者：Van den Eynden, GG; Smid, M; Van Laere, SJ; Colpaert, CG; Van der Auwera, I; Bich, TX; van Dam, P; den Bakker, MA; Dirix, LY; Van Marck, EA; Vermeulen, PB; Foekens, JA,期刊：Clinical Cancer Research, 页码：2944-2952 , 文章类型： Article，,卷期：2008年14-10]
- Purpose: A fibrotic focus, the scar-like area found in the center of an invasive breast tumor, is a prognostic parameter associated with an expansive growth pattern, hypoxia, and (lymph) angiogenesis. Little is known abo...
- Efficacy of gemcitabine in patients with non-small cell lung cancer according to promoter polymorphisms of the ribonucleotide reductase M1 gene
[作者：Kim, SO; Jeong, JY; Kim, MR; Cho, HJ; Ju, JY; Kwon, YS; Oh, IJ; Kim, KS; Kim, YL; Lim, SC; Kim, YC,期刊：Clinical Cancer Research, 页码：3083-3088 , 文章类型： Article，,卷期：2008年14-10]
- Purpose: High ribonucleotide reductase M1 (RRM1) expression in resected lung cancers has been associated with better clinical outcomes. However, gemcitabine-treated patients with high tumoral RRM1 expression generally ev...
- Inhibition of vascular endothelial growth factor-A signaling induces hypertension: Examining the effect of cediranib (Recentin; AZD2171) treatment on blood pressure in rat and the use of concomitant anti hypertensive therapy
[作者：Curwen, JO; Musgrove, HL; Kendrew, J; Richmond, GHP; Ogilvie, DJ; Wedge, SR,期刊：Clinical Cancer Research, 页码：3124-3131 , 文章类型： Article，,卷期：2008年14-10]
- Purpose: Inhibition of vascular endothelial growth factor-A (VEGF) signaling is a key therapeutic approach in oncology given the role of VEGF in angiogenesis and vascular permeability in solid tumors. Clinical trials exa...
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