- Fungal bis-Naphthopyrones as Inhibitors of Botulinum Neurotoxin Serotype A
[作者:CARDELLINA JOHN H II; ROXASDUNCAN VIRGINIA I; MONTGOMERY VICKI; ECCARD VANESSA; CAMPBELL YVETTE; HU XIN; KHAVRUTSKII ILJA; TAWA GREGORY J; WALLQVIST ANDERS; GLOER JAMES B; PHATAK NISARGA L; HOELLER ULRICH; SOMAN ASHISH G; JOSHI BIREN K; HEIN SARA M; WICKLOW DONALD T; SMITH LEONARD A,期刊:ACS Medicinal Chemistry Letters, 页码:387-391 , 文章类型: Article,,卷期:2012年3-5]
- An in silico screen of the NIH Molecular Library Small Molecule Repository (MLSMR) of similar to 350000 compounds and confirmatory bioassays led to identification of chaetochromin A (1) as an inhibitor of botulinum neuro...
- Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)
[作者:RICE KENNETH D; AAY NAING; ANAND NEEL K; BLAZEY CHARLES M; BOWLES OWEN J; BUSSENIUS JOERG; COSTANZO SIMONA; CURTIS JEFFRY K; DEFINA STEVEN C; DUBENKO LARISA; ENGST STEFAN; JOSHI ANAGHA A; KENNEDY ABIGAIL R; KIM ANGIE I; KOLTUN ELENA S; LOUGHEED JULIE C; MANALO JEANCLAIRE L; MARTINI JEANFRANCOIS; NUSS JOHN M; PETO CSABA J; TSANG TSZE H; YU PEIWEN; JOHNSTON STUART,期刊:ACS Medicinal Chemistry Letters, 页码:416-421 , 文章类型: Article,,卷期:2012年3-5]
- The ERK/MAP kinase cascade is a key mechanism subject to dysregulation in cancer and is constitutively activated or highly upregulated in many tumor types. Mutations associated with upstream pathway components RAS and Ra...
|