- CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency
[作者：van Zelm, MC; Smet, J; Adams, B; Mascart, F; Schandene, L; Janssen, F; Ferster, A; Kuo, CC; Levy, S; van Dongen, JJM; van der Burg, M,期刊：Journal of clinical investigation, 页码：1265-1274 , 文章类型： Article，,卷期：2010年120-4]
- Antibody deficiencies constitute the largest group of symptomatic primary immunodeficiency diseases. In several patients, mutations in CD19 have been found to underlie disease, demonstrating the critical role for the pro...
- Preemptive CD20(+) B cell depletion attenuates cardiac allograft vasculopathy in cyclosporine-treated monkeys
[作者：Kelishadi, SS; Azimzadeh, AM; Zhang, TS; Stoddard, T; Welty, E; Avon, C; Higuchi, M; Laaris, A; Cheng, XF; McMahon, C; Pierson, RN,期刊：Journal of clinical investigation, 页码：1275-1284 , 文章类型： Article，,卷期：2010年120-4]
- Chronic rejection currently limits the long-term efficacy of clinical transplantation. Although B cells have recently been shown to play a pivotal role in the induction of alloimmunity and are being targeted in other tra...
- Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance
[作者：Cherfils-Vicini, J; Platonova, S; Gillard, M; Laurans, L; Validire, P; Caliandro, R; Magdeleinat, P; Mami-Chouaib, F; Dieu-Nosjean, MC; Fridman, WH; Damotte, D; Sautes-Fridman, C; Cremer, I,期刊：Journal of clinical investigation, 页码：1285-1297 , 文章类型： Article，,卷期：2010年120-4]
- Compelling evidence suggests that inflammation, cell survival, and cancer are linked, with a central role played by NF-kappa B. Recent studies implicate some TLRs in tumor development based on their ability to facilitate...
- MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors
[作者：Liu, X; Sempere, LF; Ouyang, HX; Memoli, VA; Andrew, AS; Luo, Y; Demidenko, E; Korc, M; Shi, W; Preis, M; Dragnev, KH; Li, H; DiRenzo, J; Bak, M; Freemantle, SJ; Kauppinen, S; Dmitrovsky, E,期刊：Journal of clinical investigation, 页码：1298-1309 , 文章类型： Article，,卷期：2010年120-4]
- MicroRNAs (miRNAs) regulate gene expression. It has been suggested that obtaining miRNA expression profiles can improve classification, diagnostic, and prognostic information in oncology. Here, we sought to comprehensive...
- Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance
[作者：Bonapace, L; Bornhauser, BC; Schmitz, M; Cario, G; Ziegler, U; Niggli, FK; Schafer, BW; Schrappe, M; Stanulla, M; Bourquin, JP,期刊：Journal of clinical investigation, 页码：1310-1323 , 文章类型： Article，,卷期：2010年120-4]
- In vivo resistance to first-line chemotherapy, including to glucocorticoids, is a strong predictor of poor outcome in children with acute lymphoblastic leukemia (ALL). Modulation,of cell death regulators represents an at...
- Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence
[作者：Yi, W; Seth, NP; Martillotti, T; Wucherpfennig, KW; Sant'Angelo, DB; Denzin, LK,期刊：Journal of clinical investigation, 页码：1324-1336 , 文章类型： Article，,卷期：2010年120-4]
- Peptide loading of MHC class II (MHCII) molecules is directly catalyzed by the MHCII-like molecule HLA-DM (DM). Another MHCII-like molecule, HLA-DO (DO), associates with DM, thereby modulating DM function. The biological...
- Analysis of mutations from SCID and Omenn syndrome patients reveals the central role of the Rag2 PHD domain in regulating V(D)J recombination
[作者：Couedel, C; Roman, C; Jones, A; Vezzoni, P; Villa, A; Cortes, P,期刊：Journal of clinical investigation, 页码：1337-1344 , 文章类型： Article，,卷期：2010年120-4]
- Rag2 plays an essential role in the generation of antigen receptors. Mutations that impair Rag2 function can lead to severe combined immunodeficiency (SCID), a condition characterized by complete absence of T and B cells...
- Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia
[作者：Mitchell, CS; Savage, DB; Dufour, S; Schoenmakers, N; Murgatroyd, P; Befroy, D; Halsall, D; Northcott, S; Raymond-Barker, P; Curran, S; Henning, E; Keogh, J; Owen, P; Lazarus, J; Rothman, DL; Farooqi, IS; Shulman, GI; Chatterjee, K; Petersen, KF,期刊：Journal of clinical investigation, 页码：1345-1354 , 文章类型： Article，,卷期：2010年120-4]
- Resistance to thyroid hormone (RTH), a dominantly inherited disorder usually associated with mutations in thyroid hormone receptor beta (THRB), is characterized by elevated levels of circulating thyroid hormones (includi...
- The right to health care
[作者：Turka, LA; Caplan, AL,期刊：Journal of clinical investigation, 页码：934-934 , 文章类型： Editorial Material，,卷期：2010年120-4]
- While our eyes usually glaze over at the continued talk of health care reform, there are a few particulars that bear repeating. So many of the parties involved fail to consider the most basic and most important of all th...
- Ab binding alters gene expression in Cryptococcus neoformans and directly modulates fungal metabolism
[作者：McClelland, EE; Nicola, AM; Prados-Rosales, R; Casadevall, A,期刊：Journal of clinical investigation, 页码：1355-1361 , 文章类型： Article，,卷期：2010年120-4]
- Abs facilitate humoral immunity via the classical mechanisms of opsonization, complement activation, Abdependent cellular cytotoxicity, and toxin/viral neutralization. There is also evidence that some Abs mediate direct ...
- Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy (vol 120, pg 791, 2010)
[作者：O'Toole, JF; Liu, YJ; Davis, EE; Westlake, CJ; Attanasio, M; Otto, EA; Seelow, D; Nurnberg, G; Becker, C; Nuutinen, M; Karppa, M; Ignatius, J; Uusimaa, J; Pakanen, S; Jaakkola, E; van den Heuvel, LP; Fehrenbach, H; Wiggins, R; Goyal, M; Zhou, WB; Wolf, MTF; Wise, E; Helou, J; Allen, SJ; Murga-Zamalloa, CA; Ashraf, S; Chaki, M; Heeringa, S; Chernin, G; Hoskins, BE; Chaib, H; Gleeson, J; Kusakabe, T; Suzuki, T; Isaac, RE; Quarmby, LM; Tennant, B; Fujioka, H; Tuominen, H; Hassinen, I; Lohi, H; van Houten, JL; Rotig, A; Sayer, JA; Rolinski, B; Freisinger, P; Madhavan, SM; Herzer, M; Madignier, F; Prokisch, H; Nurnberg, P; Jackson, PK; Khanna, H; Katsanis, N; Hildebrandt, F,期刊：Journal of clinical investigation, 页码：1362-1362 , 文章类型： Correction，,卷期：2010年120-4]
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- APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa (vol 118, pg 2887, 2008)
[作者：Huard, B; McKee, T; Bosshard, C; Durual, S; Matthes, T; Myit, S; Donze, O; Frossard, C; Chizzolini, C; Favre, C; Zubler, R; Guyot, JP; Schneider, P; Roosnek, E,期刊：Journal of clinical investigation, 页码：1362-1362 , 文章类型： Correction，,卷期：2010年120-4]
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- How we are born
[作者：Dey, SK,期刊：Journal of clinical investigation, 页码：952-955 , 文章类型： Review，,卷期：2010年120-4]
- Human reproduction is relatively inefficient. Nearly 30% of pregnancies result in spontaneous losses, which are both a clinical problem and a psychological stress to the families involved. Furthermore, although the human...
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