- Brostallicin hydrochloride - Minor groove-binding agent, oncolytic
[作者:Amir, E; Griffiths, RW; Leahy, MG,期刊:Drugs of the Future, 页码:478-488 , 文章类型: Article,,卷期:2008年33-6]
Soft tissue sarcomas (STS) are a group of rare tumors, most of which are relatively resistant to standard chemotherapeutic agents. To date, favorable efficacy data exist for only a small number of agents in this disea...
- Reolysin(R) - Oncolytic virus
[作者:Eckschlager, T; Figova, K,期刊:Drugs of the Future, 页码:489-495 , 文章类型: Article,,卷期:2008年33-6]
Oncolytic viruses infect, replicate in and lyse tumor cells while sparing normal cells. In addition to direct lysis, viruses induce antitumor immunity and some viruses express cytotoxic proteins. Oncolytic viruses can...
- Overcoming BCRP-mediated multidrug resistance
[作者:Florin, A; Boutonnat, J; Boumendjel, A,期刊:Drugs of the Future, 页码:533-542 , 文章类型: Review,,卷期:2008年33-6]
Breast cancer resistance protein (BCRP, MXR, ABCG2) is a well-known protein related to acute myeloid leukemia (AML) resistance to chemotherapeutic treatments. This protein is a member of the ATP-binding cassette famil...
- POEMS syndrome
[作者:Laurenti, L; De Matteis, S,期刊:Drugs of the Future, 页码:543-550 , 文章类型: Review,,卷期:2008年33-6]
POEMS syndrome is a paraneoplastic disorder secondary to plasma cell dyscrasia. It is characterized by the presence of polyneuropathy (P), organomegaly (0), endocrinopathy (E), monoclonal gammopathy (M) and skin chang...
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