Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are a crucial component of current highly active antiretroviral therapy (HAART) treatments for HIV-1 infection. One of the major limitations of the two most wid...

Andersen-Tawil syndrome (ATS) is a rare inherited disorder linked to multiple mutations in distinct regions of KCNJ2, a gene that encodes potassium channels. ATS is characterized by extremely variable expression of a ...

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. A number of chemokines and their receptors are implicated in the pathogenesis of MS. CCR5 is expressed on mononuclear inf...

The 2008 Annual Meeting of the American Society of Clinical Oncology (ASCO), held on May 30-June 3 in Chicago, provided a window on the hive of activity that is current cancer therapy research. Presentations covered c...

BIBW-2992 is a potent, irreversible, orally active inhibitor of the epidermal growth factor receptor EGFR and HER2 tyrosine kinases. In preclinical studies, BIBW-2992 showed selectivity over other receptor classes and...

CMX001 is a lipid (1-O-hexadecyloxypropyl) conjugate of the phosphonate nucleotide analogue cidofovir (CDV). CDV, which is approved by the FDA for the treatment of cytomegalovirus (CMV)-induced retinitis in AIDS patie...

The emergence of point mutations in the BCR-ABL gene is associated with the development of resistance to imatinib in patients with chronic myeloid leukemia (CML). Inhibitors of Aurora kinases, enzymes essential for th...

Cystic fibrosis (CF) is a disease with a low life expectancy and a range of morbidities that result from mutations in the cystic fibrosis transmembrane regulator (CFTR) gene. In recent years, investigation has increas...

Despite recent developments in computational and chemical techniques, traditional-Medicines are considered among the most reliable lead sources for the discovery of new drugs. A vast wealth of knowledge has been accum...