- Distinct Signaling Properties of Mitogen-activated Protein Kinase Kinases 4 (MKK4) and 7 (MKK7) in Embryonic Stem Cell (ESC) Differentiation
[作者:Wang, JC; Chen, L; Ko, CI; Zhang, L; Puga, A; Xia, Y,期刊:Journal of Biological Chemistry, 页码:2787-2797 , 文章类型: Article,,卷期:2012年287-4]
- Signal transduction pathways are integral components of the developmental regulatory network that guides progressive cell fate determination. MKK4 and MKK7 are upstream kinases of the mitogen-activated protein kinases (M...
- TCF12 Protein Functions as Transcriptional Repressor of E-cadherin, and Its Overexpression Is Correlated with Metastasis of Colorectal Cancer
[作者:Lee, CC; Chen, WS; Chen, CC; Chen, LL; Lin, YS; Fan, CS; Huang, TS,期刊:Journal of Biological Chemistry, 页码:2798-2809 , 文章类型: Article,,卷期:2012年287-4]
- A correlation of TCF12 mRNA overexpression with colorectal cancer (CRC) metastasis was suggested by microarray data and validated by the survey of 120 patients. Thirty-three (27.5%) of the 120 patients showed tumor TCF12...
- A Ca(v)3.2/Syntaxin-1A Signaling Complex Controls T-type Channel Activity and Low-threshold Exocytosis
[作者:Weiss, N; Hameed, S; Fernandez-Fernandez, JM; Fablet, K; Karmazinova, M; Poillot, C; Proft, J; Chen, LN; Bidaud, I; Monteil, A; Huc-Brandt, S; Lacinova, L; Lory, P; Zamponi, GW; De Waard, M,期刊:Journal of Biological Chemistry, 页码:2810-2818 , 文章类型: Article,,卷期:2012年287-4]
- T-type calcium channels represent a key pathway for Ca2+ entry near the resting membrane potential. Increasing evidence supports a unique role of these channels in fast and low-threshold exocytosis in an action potential...
- Role of Human DNA Glycosylase Nei-like 2 (NEIL2) and Single Strand Break Repair Protein Polynucleotide Kinase 3 '-Phosphatase in Maintenance of Mitochondrial Genome
[作者:Mandal, SM; Hegde, ML; Chatterjee, A; Hegde, PM; Szczesny, B; Banerjee, D; Boldogh, I; Gao, R; Falkenberg, M; Gustafsson, CM; Sarkar, PS; Hazra, TK,期刊:Journal of Biological Chemistry, 页码:2819-2829 , 文章类型: Article,,卷期:2012年287-4]
- The repair of reactive oxygen species-induced base lesions and single strand breaks (SSBs) in the nuclear genome via the base excision (BER) and SSB repair (SSBR) pathways, respectively, is well characterize, and importa...
- CD4(+) T Cell-derived Novel Peptide Thp5 Induces Interleukin-4 Production in CD4(+) T Cells to Direct T Helper 2 Cell Differentiation
[作者:Khan, MM; Chatterjee, S; Dwivedi, VP; Pandey, NK; Singh, Y; Tousif, S; Bhavesh, NS; Van Kaer, L; Das, J; Das, G,期刊:Journal of Biological Chemistry, 页码:2830-2835 , 文章类型: Article,,卷期:2012年287-4]
- The differentiation of naive CD4(+) T cells into T helper 2 (Th2) cells requires production of the cytokine IL-4 in the local microenvironment. It is evident that naive/quiescently activated CD4(+) T cells produce the IL...
- Importance of N- and C-terminal Regions of IbpA, Escherichia coli Small Heat Shock Protein, for Chaperone Function and Oligomerization
[作者:Strozecka, J; Chrusciel, E; Gorna, E; Szymanska, A; Zietkiewicz, S; Liberek, K,期刊:Journal of Biological Chemistry, 页码:2843-2853 , 文章类型: Article,,卷期:2012年287-4]
- Small heat shock proteins are ubiquitous molecular chaperones that, during cellular stress, bind to misfolded proteins and maintain them in a refolding competent state. Two members of the small heat shock protein family,...
- Molecular Basis for the Association of Microcephalin (MCPH1) Protein with the Cell Division Cycle Protein 27 (Cdc27) Subunit of the Anaphase-promoting Complex
[作者:Singh, N; Wiltshire, TD; Thompson, JR; Mer, G; Couch, FJ,期刊:Journal of Biological Chemistry, 页码:2854-2862 , 文章类型: Article,,卷期:2012年287-4]
- Microcephalin (MCPH1), the first gene identified as causative for primary recessive autosomal microcephaly, is aberrantly expressed in autism-like disorders and human malignancy of breast and ovarian origin. MCPH1, the e...
- Gene Dose Influences Cellular and Calcium Channel Dysregulation in Heterozygous and Homozygous T4826I-RYR1 Malignant Hyperthermia-susceptible Muscle
[作者:Barrientos, GC; Feng, W; Truong, K; Matthaei, KI; Yang, TZ; Allen, PD; Lopez, JR; Pessah, IN,期刊:Journal of Biological Chemistry, 页码:2863-2876 , 文章类型: Article,,卷期:2012年287-4]
- Malignant hyperthermia susceptibility (MHS) is primarily conferred by mutations within ryanodine receptor type 1 (RYR1). Here we address how the MHS mutation T4826I within the S4-S5 linker influences excitation-contracti...
- Green Fluorescent Protein Changes the Conductance of Connexin 43 (Cx43) Hemichannels Reconstituted in Planar Lipid Bilayers
[作者:Carnarius, C; Kreir, M; Krick, M; Methfessel, C; Moehrle, V; Valerius, O; Bruggemann, A; Steinem, C; Fertig, N,期刊:Journal of Biological Chemistry, 页码:2877-2886 , 文章类型: Article,,卷期:2012年287-4]
- In mammalian tissues, connexin 43 (Cx43) is the most prominent member of the connexin family. In a single lipid bilayer, six connexin subunits assemble into a hemichannel (connexon). Direct communication of apposing cell...
- Exometabolome Analysis Identifies Pyruvate Dehydrogenase as a Target for the Antibiotic Triphenylbismuthdichloride in Multiresistant Bacterial Pathogens
[作者:Birkenstock, T; Liebeke, M; Winstel, V; Krismer, B; Gekeler, C; Niemiec, MJ; Bisswanger, H; Lalk, M; Peschel, A,期刊:Journal of Biological Chemistry, 页码:2887-2895 , 文章类型: Article,,卷期:2012年287-4]
- The desperate need for new therapeutics against notoriously antibiotic-resistant bacteria has led to a quest for novel antibacterial target structures and compounds. Moreover, defining targets and modes of action of new ...
- Functional Impact of Heterogeneous Nuclear Ribonucleoprotein A2/B1 in Smooth Muscle Differentiation from Stem Cells and Embryonic Arteriogenesis
[作者:Wang, G; Xiao, QZ; Luo, ZL; Ye, S; Xu, QB,期刊:Journal of Biological Chemistry, 页码:2896-2906 , 文章类型: Article,,卷期:2012年287-4]
- Heterogeneous nuclear ribonucleoproteins (hnRNPs) play various roles in transcriptional and post-transcriptional modulation of gene expression. However, it remains unclear if hnRNPs are associated with smooth muscle cell...
- S-Nitrosylation of Mixed Lineage Kinase 3 Contributes to Its Activation after Cerebral Ischemia
[作者:Hu, SQ; Ye, JS; Zong, YY; Sun, CC; Liu, DH; Wu, YP; Song, T; Zhang, GY,期刊:Journal of Biological Chemistry, 页码:2364-2377 , 文章类型: Article,,卷期:2012年287-4]
- Previous studies in our laboratory have shown that mixed lineage kinase 3 (MLK3) can be activated following global ischemia. In addition, other laboratories have reported that the activation of MLK3 may be linked to the ...
- Molecular Cloning and Functional Characterization of Xenopus tropicalis Frog Transient Receptor Potential Vanilloid 1 Reveal Its Functional Evolution for Heat, Acid, and Capsaicin Sensitivities in Terrestrial Vertebrates
[作者:Ohkita, M; Saito, S; Imagawa, T; Takahashi, K; Tominaga, M; Ohta, T,期刊:Journal of Biological Chemistry, 页码:2388-2397 , 文章类型: Article,,卷期:2012年287-4]
- The functional difference of thermosensitive transient receptor potential (TRP) channels in the evolutionary context has attracted attention, but thus far little information is available on the TRP vanilloid 1 (TRPV1) fu...
- Chaperoning of Mutant p53 Protein by Wild-type p53 Protein Causes Hypoxic Tumor Regression
[作者:Gogna, R; Madan, E; Kuppusamy, P; Pati, U,期刊:Journal of Biological Chemistry, 页码:2907-2914 , 文章类型: Article,,卷期:2012年287-4]
- Mutant (Mt) p53 abrogates tumor suppression functions of wild-type (WT) p53 through mutant-specific, gain-of-function effects, and patients bearing Mt p53 are chemoresistant. The dominant negative effect of p53 mutants r...
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