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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共20条记录   Telomere biology and DNA repair: Enemies with benefits Introduction [作者：de Lange, T,期刊：FEBS Letters, 页码：3673-3674 , 文章类型： Editorial Material，,卷期：2010年584-17] Multiple roles of ATM in monitoring and maintaining DNA integrity [作者：Derheimer, FA; Kastan, MB,期刊：FEBS Letters, 页码：3675-3681 , 文章类型： Review，,卷期：2010年584-17] The ability of our cells to maintain genomic integrity is fundamental for protection from cancer development. Central to this process is the ability of cells to recognize and repair DNA damage and progress through the ce... The MRN complex in double-strand break repair and telomere maintenance [作者：Lamarche, BJ; Orazio, NI; Weitzman, MD,期刊：FEBS Letters, 页码：3682-3695 , 文章类型： Review，,卷期：2010年584-17] Genomes are subject to constant threat by damaging agents that generate DNA double-strand breaks (DSBs). The ends of linear chromosomes need to be protected from DNA damage recognition and end-joining, and this is achiev... Regulation of homologous recombination at telomeres in budding yeast [作者：Eckert-Boulet, N; Lisby, M,期刊：FEBS Letters, 页码：3696-3702 , 文章类型： Review，,卷期：2010年584-17] Homologous recombination is suppressed at normal length telomere sequences. In contrast, telomere recombination is allowed when telomeres erode in the absence of telomerase activity or as a consequence of nucleolytic deg... Collaboration and competition between DNA double-strand break repair pathways [作者：Kass, EM; Jasin, M,期刊：FEBS Letters, 页码：3703-3708 , 文章类型： Review，,卷期：2010年584-17] DNA double-strand breaks resulting from normal cellular processes including replication and exogenous sources such as ionizing radiation pose a serious risk to genome stability, and cells have evolved different mechanism... Metabolism of postsynaptic recombination intermediates [作者：Adelman, CA; Boulton, SJ,期刊：FEBS Letters, 页码：3709-3716 , 文章类型： Review，,卷期：2010年584-17] DNA double strand breaks and blocked or collapsed DNA replication forks are potentially genotoxic lesions that can result in deletions, aneuploidy or cell death. Homologous recombination (HR) is an essential process empl... Focus on histone variant H2AX: To be or not to be [作者：Yuan, JS; Adamski, R; Chen, JJ,期刊：FEBS Letters, 页码：3717-3724 , 文章类型： Review，,卷期：2010年584-17] Phosphorylation of histone variant H2AX at serine 139, named gamma H2AX, has been widely used as a sensitive marker for DNA double-strand breaks (DSBs). gamma H2AX is required for the accumulation of many DNA damage resp... Fission yeast telomeres forecast the end of the crisis [作者：Dehe, PM; Cooper, JP,期刊：FEBS Letters, 页码：3725-3733 , 文章类型： Review，,卷期：2010年584-17] Recent years have placed fission yeast at the forefront of telomere research, as this organism combines a high level of conservation with human telomeres and precise genetic manipulability. Here we highlight some of the ... When the caps fall off: Responses to telomere uncapping in yeast [作者：Wellinger, RJ,期刊：FEBS Letters, 页码：3734-3740 , 文章类型： Review，,卷期：2010年584-17] Telomeres protect the ends of linear chromosomes from activities that cause sequence losses or challenge chromosome integrity. Furthermore, these ends must be hidden from detection by the DNA damage recognition and respo... Telomere biology in Metazoa [作者：Gomes, NMV; Shay, JW; Wright, WE,期刊：FEBS Letters, 页码：3741-3751 , 文章类型： Review，,卷期：2010年584-17] In this review we present critical overview of some of the available literature on the fundamental biology of telomeres and telomerase in Metazoan. With the exception of Nematodes and Arthropods, the (TTAGGG)(n) sequence... Comparative biology of telomeres: Where plants stand [作者：Watson, JM; Riha, K,期刊：FEBS Letters, 页码：3752-3759 , 文章类型： Review，,卷期：2010年584-17] Telomeres are essential structures at the ends of eukaryotic chromosomes. Work on their structure and function began almost 70 years ago in plants and flies, continued through the Nobel Prize winning work on yeast and ci... Telomeres: Structures in need of unwinding [作者：Paeschke, K; McDonald, KR; Zakian, VA,期刊：FEBS Letters, 页码：3760-3772 , 文章类型： Review，,卷期：2010年584-17] Telomeres protect the ends of eukaryotic chromosomes from being recognized and processed as double strand breaks. In most organisms, telomeric DNA is highly repetitive with a high GC-content. Moreover, the G residues are... Defending the end zone: Studying the players involved in protecting chromosome ends [作者：Chan, SS; Chang, S,期刊：FEBS Letters, 页码：3773-3778 , 文章类型： Review，,卷期：2010年584-17] The linear nature of eukaryotic chromosomes leaves natural DNA ends susceptible to triggering DNA damage responses. Telomeres are specialized nucleoprotein structures that comprise the "end zone" of chromosomes. Besides ... Pot1 and telomere maintenance [作者：Baumann, P; Price, C,期刊：FEBS Letters, 页码：3779-3784 , 文章类型： Review，,卷期：2010年584-17] Proteins that specifically bind the single-stranded overhang at the ends of telomeres have been identified in a wide range of eukaryotes and play pivotal roles in chromosome end protection and telomere length regulation.... Structural identity of telomeric complexes [作者：Giraud-Panis, MJ; Pisano, S; Poulet, A; Le Du, MH; Gilson, E,期刊：FEBS Letters, 页码：3785-3799 , 文章类型： Review，,卷期：2010年584-17] A major issue in telomere research is to understand how the integrity of chromosome ends is controlled. Although several nucleoprotein complexes have been described at the telomeres of different organisms, it is still un... Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers [作者：Henson, JD; Reddel, RR,期刊：FEBS Letters, 页码：3800-3811 , 文章类型： Review，,卷期：2010年584-17] Alternative Lengthening of Telomeres (ALT) activity can be deduced from the presence of telomere length maintenance in the absence of telomerase activity. More convenient assays for ALT utilize phenotypic markers of ALT ...