FEBS Letters————————个性化文献订阅—

Wilms' tumor protein Wt1 regulates the Interleukin-10 (IL-10) gene
[作者：Sciesielski, LK; Kirschner, KM; Scholz, H; Persson, AB,期刊：FEBS Letters, 页码：4665-4671 , 文章类型： Article，,卷期：2010年584-22]
We identified the Wilms' tumor protein, Wt1, as a novel transcriptional activator of the immunosuppressant cytokine interleukin-10 (IL-10). Silencing of Wt1 by RNA interference reduced IL-10 mRNA levels by approximate...

Inhibition of the JNK/Bim pathway by Hsp70 prevents Bax activation in UV-induced apoptosis
[作者：Li, H; Liu, L; Xing, D; Chen, WR,期刊：FEBS Letters, 页码：4672-4678 , 文章类型： Article，,卷期：2010年584-22]
Here we studied the mechanism by which heat shock protein 70 (Hsp70) prevents Bax activation during ultraviolet (UV)-induced apoptosis. UV treatment led to c-Jun N-terminal kinase (JNK) phosphorylation, Bim redistribu...

Inhibition of NF-kappa B induces a switch from CD95L-dependent to CD95L-independent and JNK-mediated apoptosis in T cells
[作者：Kiessling, MK; Linke, B; Brechmann, M; Suss, D; Krammer, PH; Gulow, K,期刊：FEBS Letters, 页码：4679-4688 , 文章类型： Article，,卷期：2010年584-22]
NF-kappa B is a crucial transcription factor regulating apoptosis sensitivity and resistance. It has been shown that inhibition of NF-kappa B in T lymphocytes leads to sensitization towards apoptosis. The underlying m...

POSH promotes cell survival in Drosophila and in human RASF cells
[作者：Tsuda, M; Kawaida, R; Kobayashi, K; Shinagawa, A; Sawada, T; Yamada, R; Yamamoto, K; Aigaki, T,期刊：FEBS Letters, 页码：4689-4694 , 文章类型： Article，,卷期：2010年584-22]
In Drosophila, Eiger, a tumor necrosis factor a (TNF alpha) superfamily ligand, induces cell death by activating the c-Jun N-terminal kinase (JNK) pathway. Here, we report that overexpression of Plenty of SH3s (POSH) sup...

MDM2 promotes cell motility and invasiveness through a RING-finger independent mechanism
[作者：Polanski, R; Warburton, HE; Ray-Sinha, A; Devling, T; Pakula, H; Rubbi, CP; Vlatkovic, N; Boyd, MT,期刊：FEBS Letters, 页码：4695-4702 , 文章类型： Article，,卷期：2010年584-22]
Recent studies connect MDM2 with increased cell motility, invasion and/or metastasis proposing an MDM2-mediated ubiquitylation-dependent mechanism. Interestingly, in renal cell carcinoma (RCC) p53/MDM2 co-expression is a...

Decreased prereceptorial glucocorticoid activating capacity in starvation due to an oxidative shift of pyridine nucleotides in the endoplasmic reticulum
[作者：Kereszturi, E; Kalman, FS; Kardon, T; Csala, M; Banhegyi, G,期刊：FEBS Letters, 页码：4703-4708 , 文章类型： Article，,卷期：2010年584-22]
Redox state of pyridine nucleotides of the endoplasmic reticulum (ER) lumen was determined in different nutritional conditions. NADPH-dependent cortisone reduction and NADP(+)-dependent cortisol oxidation were measured i...

Secondary necrosis: The natural outcome of the complete apoptotic program
[作者：Silva, MT,期刊：FEBS Letters, 页码：4491-4499 , 文章类型： Review，,卷期：2010年584-22]
The predominant definition of apoptosis considers that the elimination of the apoptosing cell is by heterolytic degradation following phagocytosis by an assisting scavenger (efferocytosis). However, an alternative and la...

Leu628 of the KIX domain of CBP is a key residue for the interaction with the MLL transactivation domain
[作者：Arai, M; Dyson, HJ; Wright, PE,期刊：FEBS Letters, 页码：4500-4504 , 文章类型： Article，,卷期：2010年584-22]
Physical interaction between the transactivation domain (TAD) of the mixed-lineage leukemia protein (MLL) and the KIX domain of the cyclic-AMP response element binding protein (CREB) binding protein (CBP) is necessary fo...

Hip2 interacts with cyclin B1 and promotes its degradation through the ubiquitin proteasome pathway
[作者：Bae, Y; Choi, D; Rhim, H; Kang, S,期刊：FEBS Letters, 页码：4505-4510 , 文章类型： Article，,卷期：2010年584-22]
Hip2, a ubiquitin conjugating enzyme, is involved in the suppression of cell death. The present study revealed that Hip2 regulates the stability of the apoptotic and cell cycle regulator cyclin B1. Hip2 was found to inte...

LIM domain protein FHL1B interacts with PP2A catalytic beta subunit - A novel cell cycle regulatory pathway
[作者：Wong, CH; Fung, YWW; Ng, EKO; Lee, SMY; Waye, MMY; Tsui, SKW,期刊：FEBS Letters, 页码：4511-4516 , 文章类型： Article，,卷期：2010年584-22]
Four-and-a-half LIM domain protein 1B (FHL1B) is an alternatively-spliced isoform of FHL1. In this study, FHL1B was demonstrated to interact with the beta catalytic subunit (C beta) of a type 2A protein phosphatase (PP2A...

Regulation of nuclear localization signal-importin alpha interaction by Ca2+/S100A6
[作者：Takata, M; Shimamoto, S; Yamaguchi, F; Tokuda, M; Tokumitsu, H; Kobayashi, R,期刊：FEBS Letters, 页码：4517-4523 , 文章类型： Article，,卷期：2010年584-22]
Although the precise intracellular roles of S100 proteins are not fully understood, these proteins are thought to be involved in Ca2+-dependent diverse signal transduction pathways. In this report, we identified importin...

NEMO stabilizes c-Myc through direct interaction in the nucleus
[作者：Kim, BY; Yang, JS; Kwak, SY; Zhang, XK; Han, YH,期刊：FEBS Letters, 页码：4524-4530 , 文章类型： Article，,卷期：2010年584-22]
The transcription factor c-Myc is a cellular oncoprotein generally upregulated in most of human cancers. NF-kappa B essential modulator (NEMO) caused phosphorylation and stabilization of c-Myc protein in the nucleus thro...

Menin stimulates homology-directed DNA repair
[作者：Gallo, A; Agnese, S; Esposito, I; Galgani, M; Avvedimento, VE,期刊：FEBS Letters, 页码：4531-4536 , 文章类型： Article，,卷期：2010年584-22]
Menin, the nuclear protein encoded by the Multiple Endocrine Neoplasia type 1 (MEN1) gene, acts as a tumor suppressor. It interacts with a large number of proteins involved in chromatin modification, transcription, cell ...

A mammalian insulysin homolog is regulated by enzyme IIA(Glc) of the glucose transport system in Vibrio vulnificus
[作者：Kim, YJ; Ryu, Y; Koo, BM; Lee, NY; Chun, SJ; Park, SJ; Lee, KH; Seok, YJ,期刊：FEBS Letters, 页码：4537-4544 , 文章类型： Article，,卷期：2010年584-22]
Vibrio vulnificus is an opportunistic human pathogen that causes severe infections in susceptible individuals. While the components of the Escherichia coli phosphoenolpyruvate: sugar phosphotransferase system (PTS) have ...

CSN5/Jab1 controls multiple events in the mammalian cell cycle
[作者：Yoshida, A; Yoneda-Kato, N; Panattoni, M; Pardi, R; Kato, J,期刊：FEBS Letters, 页码：4545-4552 , 文章类型： Article，,卷期：2010年584-22]
The COP9 signalosome (CSN) complex is critical for mammalian cell proliferation and survival, but it is not known how the CSN affects the cell cycle. In this study, MEFs lacking CSN5/Jab1 were generated using a CRE-flox ...

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