- Systematic Chromosomal Deletion of Bacterial Ribosomal Protein Genes
[作者:Shoji, S; Dambacher, CM; Shajani, Z; Williamson, JR; Schultz, PG,期刊:Journal of Molecular Biology, 页码:751-761 , 文章类型: Article,,卷期:2011年413-4]
- Detailed studies of ribosomal proteins (RPs), essential components of the protein biosynthetic machinery, have been hampered by the lack of readily accessible chromosomal deletions of the corresponding genes. Here, we re...
- Analysis of Binding Site Hot Spots on the Surface of Ras GTPase
[作者:Buhrman, G; O'Connor, C; Zerbe, B; Kearney, BM; Napoleon, R; Kovrigina, EA; Vajda, S; Kozakov, D; Kovrigin, EL; Mattos, C,期刊:Journal of Molecular Biology, 页码:773-789 , 文章类型: Article,,卷期:2011年413-4]
- We have recently discovered an allosteric switch in Ras, bringing an additional level of complexity to this GTPase whose mutants are involved in nearly 30% of cancers. Upon activation of the allosteric switch, there is a...
- Composition and Topology of the Endoplasmic Reticulum-Mitochondria Encounter Structure
[作者:Stroud, DA; Oeljeklaus, S; Wiese, S; Bohnert, M; Lewandrowski, U; Sickmann, A; Guiard, B; van der Laan, M; Warscheid, B; Wiedemann, N,期刊:Journal of Molecular Biology, 页码:743-750 , 文章类型: Article,,卷期:2011年413-4]
- Eukaryotic cells contain multiple organelles, which are functionally and structurally interconnected. The endoplasmic reticulum-mitochondria encounter structure (ERMES) forms a junction between mitochondria and the endop...
- The NLRP12 Pyrin Domain: Structure, Dynamics, and Functional Insights
[作者:Pinheiro, AS; Eibl, C; Ekman-Vural, Z; Schwarzenbacher, R; Peti, W,期刊:Journal of Molecular Biology, 页码:790-803 , 文章类型: Article,,卷期:2011年413-4]
- The initial line of defense against infection is sustained by the innate immune system. Together, membrane-bound Toll-like receptors and cytosolic nucleotide-binding domain and leucine-rich repeat-containing receptors (N...
- Cyt1Aa Toxin: Crystal Structure Reveals Implications for Its Membrane-Perforating Function
[作者:Cohen, S; Albeck, S; Ben-Dov, E; Cahan, R; Firer, M; Zaritsky, A; Dym, O,期刊:Journal of Molecular Biology, 页码:804-814 , 文章类型: Article,,卷期:2011年413-4]
- During sporulation, Bacillus thuringiensis subsp. israelensis produces a mosquito larvicidal protein complex containing several crystalline and cytolytic (Cyt) toxins. Here, the activated monomeric form of Cyt1Aa, the mo...
- DARPins Recognizing the Tumor-Associated Antigen EpCAM Selected by Phage and Ribosome Display and Engineered for Multivalency
[作者:Stefan, N; Martin-Killias, P; Wyss-Stoeckle, S; Honegger, A; Zangemeister-Wittke, U; Pluckthun, A,期刊:Journal of Molecular Biology, 页码:826-843 , 文章类型: Article,,卷期:2011年413-4]
- Designed Ankyrin Repeat Proteins (DARPins) represent a novel class of binding molecules. Their favorable biophysical properties such as high affinity, stability and expression yields make them ideal candidates for tumor ...
- Impairment of Ubiquitin-Proteasome System by E334K cMyBPC Modifies Channel Proteins, Leading to Electrophysiological Dysfunction
[作者:Bahrudin, U; Morikawa, K; Takeuchi, A; Kurata, Y; Miake, J; Mizuta, E; Adachi, K; Higaki, K; Yamamoto, Y; Shirayoshi, Y; Yoshida, A; Kato, M; Yamamoto, K; Nanba, E; Morisaki, H; Morisaki, T; Matsuoka, S; Ninomiya, H; Hisatome, I,期刊:Journal of Molecular Biology, 页码:857-878 , 文章类型: Article,,卷期:2011年413-4]
- Cardiac arrhythmogenesis is regulated by channel proteins whose protein levels are in turn regulated by the ubiquitin-proteasome system (UPS). We have previously reported on UPS impairment induced by E334K cardiac myosin...
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