- Autotransporter beta-Domains Have a Specific Function in Protein Secretion beyond Outer-Membrane Targeting
[作者:Sauri, A; Oreshkova, N; Soprova, Z; Jong, WSP; Sani, M; Peters, PJ; Luirink, J; van Ulsen, P,期刊:Journal of Molecular Biology, 页码:553-567 , 文章类型: Article,,卷期:2011年412-4]
- Autotransporters (ATs) of Gram-negative bacteria contain an N-proximal passenger domain that is transported to the extracellular milieu and a C-terminal beta-domain that inserts into the outer membrane (OM) in a beta-bar...
- Ultrasonication-Dependent Acceleration of Amyloid Fibril Formation
[作者:So, M; Yagi, H; Sakurai, K; Ogi, H; Naiki, H; Goto, Y,期刊:Journal of Molecular Biology, 页码:568-577 , 文章类型: Article,,卷期:2011年412-4]
- Amyloid fibrils, similar to crystals, form through nucleation and growth. Because of the high free-energy barrier of nucleation, the spontaneous formation of amyloid fibrils occurs only after a long lag phase. Ultrasonic...
- Active State of Sensory Rhodopsin II: Structural Determinants for Signal Transfer and Proton Pumping
[作者:Gushchin, I; Reshetnyak, A; Borshchevskiy, V; Ishchenko, A; Round, E; Grudinin, S; Engelhard, M; Buldt, G; Gordeliy, V,期刊:Journal of Molecular Biology, 页码:591-600 , 文章类型: Article,,卷期:2011年412-4]
- The molecular mechanism of transmembrane signal transduction is still a pertinent question in cellular biology. Generally, a receptor can transfer an external signal via its cytoplasmic surface, as found for G-protein-co...
- The T beta R-I Pre-Helix Extension Is Structurally Ordered in the Unbound Form and Its Flanking Prolines Are Essential for Binding
[作者:Zuniga, JE; Ilangovan, U; Mahlawat, P; Hinck, CS; Huang, T; Groppe, JC; McEwen, DG; Hinck, AP,期刊:Journal of Molecular Biology, 页码:601-618 , 文章类型: Article,,卷期:2011年412-4]
- Transforming growth factor beta isoforms (TGF-beta) are among the most recently evolved members of a signaling superfamily with more than 30 members. TGF-beta play vital roles in regulating cellular growth and differenti...
- NMR-Based Substrate Analog Docking to Escherichia coli Peptidyl-tRNA Hydrolase
[作者:Giorgi, L; Plateau, P; O'Mahony, G; Aubard, C; Fromant, M; Thureau, A; Grotli, M; Blanquet, S; Bontems, F,期刊:Journal of Molecular Biology, 页码:619-633 , 文章类型: Article,,卷期:2011年412-4]
- Escherichia coli peptidyl-tRNA hydrolase activity is inhibited by 3'-(L-[N,N-diacetyl-lysinyl)amino-3'-deoxyadenosine, a stable mimic of the minimalist substrate 2'(3')-O-(L-[N,N-diacetyl-lysinyl)adenosine. The complex o...
- Structural Constraints in Collaborative Competition of Transcription Factors against the Nucleosome
[作者:Moyle-Heyrman, G; Tims, HS; Widom, J,期刊:Journal of Molecular Biology, 页码:634-646 , 文章类型: Article,,卷期:2011年412-4]
- Cooperativity in transcription factor (TF) binding is essential in eukaryotic gene regulation and arises through diverse mechanisms. Here, we focus on one mechanism, collaborative competition, which is of interest becaus...
- Increased Hydrophobicity and Decreased Backbone Flexibility Explain the Lower Solubility of a Cataract-Linked Mutant of YD-Crystallin
[作者:Banerjee, PR; Puttamadappa, SS; Pande, A; Shekhtman, A; Pande, J,期刊:Journal of Molecular Biology, 页码:647-659 , 文章类型: Article,,卷期:2011年412-4]
- A number of point mutations in gamma D-crystallin are associated with human cataract. The Pro23-to-Thr (P23T) mutation is perhaps the most common, is geographically widespread, and presents itself in a variety of phenoty...
- Toward the Molecular Basis of Inherited Prion Diseases: NMR Structure of the Human Prion Protein with V210I Mutation
[作者:Biljan, I; Ilc, G; Giachin, G; Raspadori, A; Zhukov, I; Plavec, J; Legname, G,期刊:Journal of Molecular Biology, 页码:660-673 , 文章类型: Article,,卷期:2011年412-4]
- The development of transmissible spongiform encephalopathies (TSEs) is associated with the conversion of the cellular prion protein (PrP(C)) into a misfolded, pathogenic isoform (PrP(Sc)). Spontaneous generation of PrP(S...
- Duplex Unwinding and ATPase Activities of the DEAD-Box Helicase eIF4A Are Coupled by eIF4G and eIF4B
[作者:Ozes, AR; Feoktistova, K; Avanzino, BC; Fraser, CS,期刊:Journal of Molecular Biology, 页码:674-687 , 文章类型: Article,,卷期:2011年412-4]
- Eukaryotic initiation factor (eIF) 4A is a DEAD-box helicase that stimulates translation initiation by unwinding mRNA secondary structure. The accessory proteins eIF4G, eIF4B, and eIF4H enhance the duplex unwinding activ...
- Crystal Structures of Cobalamin-Independent Methionine Synthase (MetE) from Streptococcus mutans: A Dynamic Zinc-Inversion Model
[作者:Fu, TM; Almqvist, J; Liang, YH; Li, LF; Huang, YF; Su, XD,期刊:Journal of Molecular Biology, 页码:688-697 , 文章类型: Article,,卷期:2011年412-4]
- Cobalamin-independent methionine synthase (MetE) catalyzes the direct transfer of a methyl group from methyltetrahydrofolate to L-homocysteine to form methionine. Previous studies have shown that the MetE active site coo...
- The Staphylococcus aureus Pathogenicity Island 1 Protein gp6 Functions as an Internal Scaffold during Capsid Size Determination
[作者:Dearborn, AD; Spilman, MS; Damle, PK; Chang, JR; Monroe, EB; Saad, JS; Christie, GE; Dokland, T,期刊:Journal of Molecular Biology, 页码:710-722 , 文章类型: Article,,卷期:2011年412-4]
- Staphylococcus aureus pathogenicity island 1 (SaPI1) is a mobile genetic element that carries genes for several superantigen toxins. SaPI1 is normally stably integrated into the host genome but can become mobilized by "h...
- Interstitial Contacts in an RNA-Dependent RNA Polymerase Lattice
[作者:Tellez, AB; Wang, J; Tanner, EJ; Spagnolo, JF; Kirkegaard, K; Bullitt, E,期刊:Journal of Molecular Biology, 页码:737-750 , 文章类型: Article,,卷期:2011年412-4]
- Catalytic activities can be facilitated by ordered enzymatic arrays that co-localize and orient enzymes and their substrates. The purified RNA-dependent RNA polymerase from poliovirus self-assembles to form two-dimension...
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