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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共6条记录   Impact of poor-quality medicines in the 'developing' world [作者：Newton, PN; Green, MD; Fernandez, FM,期刊：Trends in Pharmacological Sciences, 页码：99-101 , 文章类型： Article，,卷期：2010年31-3] Since our ancestors began trading several millennia ago, counterfeit and substandard medicines have been a recurring problem, with history punctuated by crises in the supply of anti-microbials, such as fake cinchona bark... Dual COXIB/TP antagonists: a possible new twist in NSAID pharmacology and cardiovascular risk [作者：Rovati, GE; Sala, A; Capra, V; Dahlen, SE; Folco, G,期刊：Trends in Pharmacological Sciences, 页码：102-107 , 文章类型： Review，,卷期：2010年31-3] In the 1990s, after identification of two cyclo-oxygenase (COX) isoforms catalyzing the synthesis of prostaglandins and thromboxane A(2) (TXA(2)), a new class of nonsteroidal anti-inflammatory drug (NSAID) became availab... Gender differences in drug toxicity [作者：Nicolson, TJ; Mellor, HR; Roberts, RRA,期刊：Trends in Pharmacological Sciences, 页码：108-114 , 文章类型： Review，,卷期：2010年31-3] Clinical data suggest that gender dimorphic profiles are emerging in terms of both drug efficacy and adverse drug reactions (ADRs). With an increasing emphasis on individualised therapies and the need to prevent drug att... Unveiling the role of network and systems biology in drug discovery [作者：Pujol, A; Mosca, R; Farres, J; Aloy, P,期刊：Trends in Pharmacological Sciences, 页码：115-123 , 文章类型： Review，,卷期：2010年31-3] Network and systems biology offer a novel way of approaching drug discovery by developing models that consider the global physiological environment of protein targets, and the effects of modifying them, without losing th... Receptor heteromerization and drug discovery [作者：Rozenfeld, R; Devi, LA,期刊：Trends in Pharmacological Sciences, 页码：124-130 , 文章类型： Review，,卷期：2010年31-3] G-protein-coupled receptors (GPCRs) are membrane proteins that convert extracellular information into intracellular signals. They are involved in many biological processes and therefore represent powerful targets to modu... Vas deferens - A model used to establish sympathetic cotransmission [作者：Burnstock, G; Verkhratsky, A,期刊：Trends in Pharmacological Sciences, 页码：131-139 , 文章类型： Review，,卷期：2010年31-3] The vas deferens has been used as a model for many diverse studies of different aspects of autonomic neuro-transmission since its introduction including, in particular, sympathetic cotransmission involving release of ATP...