- Neuropathic and chronic pain stimuli downregulate central mu -opioid and dopaminergic transmission
[作者:Niikura, K; Narita, M; Butelman, ER; Kreek, MJ; Suzuki, T,期刊:Trends in Pharmacological Sciences, 页码:299-305 , 文章类型: Review,,卷期:2010年31-7]
- Although morphine and other mu-opioid agonists are the main analgesics for severe pain, these compounds have potential for abuse and/or addiction. This has complicated the use of mu-agonists in the treatment of chronic p...
- Functional mapping of drug response with pharmacodynamic-pharmacokinetic principles
[作者:Ahn, K; Luo, JT; Berg, A; Keefe, D; Wu, RL,期刊:Trends in Pharmacological Sciences, 页码:306-311 , 文章类型: Review,,卷期:2010年31-7]
- Recent research in pharmacogenomics has inspired our hope to predict drug response by linking it with DNA information extracted from the human genome. However, many genetic models of drug response do not incorporate bioc...
- Activation of the hypothalamic-pituitary-adrenal axis by addictive drugs: different pathways, common outcome
[作者:Armario, A,期刊:Trends in Pharmacological Sciences, 页码:318-325 , 文章类型: Review,,卷期:2010年31-7]
- Addictive drugs (opiates, ethanol, cannabinoids (CBs), nicotine, cocaine, amphetamines) induce activation of the hypothalamic pituitary adrenal (HPA) axis, with the subsequent release of adrenocorticotropic hormone and g...
|