- Structure-Based Analysis of the Molecular Recognitions Between HIV-1 TAR-RNA and Transcription Factor Nuclear Factor-kappaB (NFkB)
[作者:Khan, MTH; Mischiati, C; Ather, A; Ohyama, T; Dedachi, K; Borgatti, M; Kurita, N; Gambari, R,期刊:Current Topics in Medicinal Chemistry, 页码:814-827 , 文章类型: Review,,卷期:2012年12-8]
- In this paper we applied the "macromolecular docking" procedure to perform molecular modeling with the aim of screening transcription factor sequences for possible interaction to the HIV-1 TAR-RNA, employing the software...
- Review of Synthesis, Assay, and Prediction of beta and gamma- secretase Inhibitors
[作者:Nino, H; Rodriguez-Borges, JE; Garcia-Mera, X; Prado-Prado, F,期刊:Current Topics in Medicinal Chemistry, 页码:828-844 , 文章类型: Review,,卷期:2012年12-8]
- Alzheimer's disease (AD) is characterize with several pathologies this disease, amyloid plaques, composed of the beta-amyloid peptide and gamma-amyloid peptide are hallmark neuropathological lesions in Alzheimer's diseas...
- A Review of QSAR studies to Discover New Drug-like Compounds Actives Against Leishmaniasis and Trypanosomiasis
[作者:Castillo-Garit, JA; Abad, C; Rodriguez-Borges, JE; Marrero-Ponce, Y; Torrens, F,期刊:Current Topics in Medicinal Chemistry, 页码:852-865 , 文章类型: Review,,卷期:2012年12-8]
- The neglected tropical diseases (NTDs) affect more than one billion people (one-sixth of the world's population) and occur primarily in undeveloped countries in sub-Saharan Africa, Asia, and Latin America. Available drug...
- Recent Advances on A(3) Adenosine Receptor Antagonists by QSAR Tools
[作者:Luan, F; Borges, F; Cordeiro, MNDS,期刊:Current Topics in Medicinal Chemistry, 页码:878-894 , 文章类型: Review,,卷期:2012年12-8]
- Adenosine receptors (ARs) are widespread on virtually every human organ/tissue, and have long been considered promising therapeutic targets in a wide range of conditions, ranging from cerebral diseases to cancer, includi...
- Review of Synthesis, Biological Assay, and QSAR Studies of HMGR Inhibitors
[作者:Garcia, I; Fall, Y; Gomez, G,期刊:Current Topics in Medicinal Chemistry, 页码:895-919 , 文章类型: Review,,卷期:2012年12-8]
- Effective as statin drugs or acids are inhibitors mevinic limiting enzyme in cholesterol biosynthesis, 3-hydroxy-3-methyl-glutaryl coenzyme A-3-hydroxy-3-reductase (HMGR), an enzyme responsible for the reduction the doub...
- From QSAR models of Drugs to Complex Networks: State-of-Art Review and Introduction of New Markov-Spectral Moments Indices
[作者:Riera-Fernandez, P; Martin-Romalde, R; Prado-Prado, FJ; Escobar, M; Munteanu, CR; Concu, R; Duardo-Sanchez, A; Gonzalez-Diaz, H,期刊:Current Topics in Medicinal Chemistry, 页码:927-960 , 文章类型: Review,,卷期:2012年12-8]
- Quantitative Structure-Activity/Property Relationships (QSAR/QSPR) models have been largely used for different kind of problems in Medicinal Chemistry and other Biosciences as well. Nevertheless, the applications of QSAR...
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