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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共47条记录   Oncogenic JAK2V617F requires an intact SH2-like domain for constitutive activation and induction of a myeloproliferative disease in mice [作者：Gorantla, SP; Dechow, TN; Grundler, R; Illert, AL; zum Buschenfelde, CM; Kremer, M; Peschel, C; Duyster, J,期刊：Blood, 页码：4600-4611 , 文章类型： Article，,卷期：2010年116-22] The oncogenic JAK2V617F mutation is found in myeloproliferative neoplasms (MPNs) and is believed to be critical for leukemogenesis. Here we show that JAK2V617F requires an intact SH2 domain for constitutive activation of... Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model [作者：Sinenko, SA; Hung, T; Moroz, T; Tran, QM; Sidhu, S; Cheney, MD; Speck, NA; Banerjee, U,期刊：Blood, 页码：4612-4620 , 文章类型： Article，,卷期：2010年116-22] Among mutations in human Runx1/AML1 transcription factors, the t(8;21)(q22;q22) genomic translocation that creates an AML1-ETO fusion protein is implicated in etiology of the acute myeloid leukemia. To identify genes and... BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34(+) cells [作者：Rizo, A; Horton, SJ; Olthof, S; Dontje, B; Ausema, A; van Os, R; van den Boom, V; Vellenga, E; de Haan, G; Schuringa, JJ,期刊：Blood, 页码：4621-4630 , 文章类型： Article，,卷期：2010年116-22] The major limitation for the development of curative cancer therapies has been an incomplete understanding of the molecular mechanisms driving cancer progression. Human models to study the development and progression of ... Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux [作者：Troadec, MB; Ward, DM; Lo, E; Kaplan, J; De Domenico, I,期刊：Blood, 页码：4657-4664 , 文章类型： Article，,卷期：2010年116-22] Ferroportin (Fpn) is the only known iron exporter in vertebrate cells and plays a critical role in iron homeostasis regulating cytosolic iron levels and exporting iron to plasma. Ferroportin1 (FPN1) expression can be tra... Endothelium-derived but not platelet-derived protein disulfide isomerase is required for thrombus formation in vivo [作者：Jasuja, R; Furie, B; Furie, BC,期刊：Blood, 页码：4665-4674 , 文章类型： Article，,卷期：2010年116-22] Protein disulfide isomerase (PDI) catalyzes the oxidation reduction and isomerization of disulfide bonds. We have previously identified an important role for extracellular PDI during thrombus formation in vivo. Here, we ... Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder: mutation classes correlate with progression to myeloid leukemia [作者：Kanezaki, R; Toki, T; Terui, K; Xu, G; Wang, RN; Shimada, A; Hama, A; Kanegane, H; Kawakami, K; Endo, M; Hasegawa, D; Kogawa, K; Adachi, S; Ikeda, Y; Iwamoto, S; Taga, T; Kosaka, Y; Kojima, S; Hayashi, Y; Ito, E,期刊：Blood, 页码：4631-4638 , 文章类型： Article，,卷期：2010年116-22] Twenty percent to 30% of transient abnormal myelopoiesis (TAM) observed in newborns with Down syndrome (DS) develop myeloid leukemia of DS (ML-DS). Most cases of TAM carry somatic GATA1 mutations resulting in the exclusi... Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function [作者：Goodall, AH; Burns, P; Salles, I; Macaulay, IC; Jones, CI; Ardissino, D; de Bono, B; Bray, SL; Deckmyn, H; Dudbridge, F; Fitzgerald, DJ; Garner, SF; Gusnanto, A; Koch, K; Langford, C; O'Connor, MN; Rice, CM; Stemple, D; Stephens, J; Trip, MD; Zwaginga, JJ; Samani, NJ; Watkins, NA; Maguire, PB; Ouwehand, WH,期刊：Blood, 页码：4646-4656 , 文章类型： Article，,卷期：2010年116-22] Within the healthy population, there is substantial, heritable, and interindividual variability in the platelet response. We explored whether a proportion of this variability could be accounted for by interindividual var... Laser-induced endothelial cell activation supports fibrin formation [作者：Atkinson, BT; Jasuja, R; Chen, VM; Nandivada, P; Furie, B; Furie, BC,期刊：Blood, 页码：4675-4683 , 文章类型： Article，,卷期：2010年116-22] Laser-induced vessel wall injury leads to rapid thrombus formation in an animal thrombosis model. The target of laser injury is the endothelium. We monitored calcium mobilization to assess activation of the laser-targete... Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk [作者：Zhang, H; Lowenberg, EC; Crosby, JR; MacLeod, AR; Zhao, CG; Gao, DC; Black, C; Revenko, AS; Meijers, JCM; Stroes, ES; Levi, M; Monia, BP,期刊：Blood, 页码：4684-4692 , 文章类型： Article，,卷期：2010年116-22] Existing anticoagulants effectively inhibit the activity of coagulation factors of the extrinsic and common pathway but have substantial limitations and can cause severe bleeding complications. Here we describe a novel t... Allogeneic hematopoietic cell transplantation for hematologic malignancy: relative risks and benefits of double umbilical cord blood [作者：Brunstein, CG; Gutman, JA; Weisdorf, DJ; Woolfrey, AE; DeFor, TE; Gooley, TA; Verneris, MR; Appelbaum, FR; Wagner, JE; Delaney, C,期刊：Blood, 页码：4693-4699 , 文章类型： Article，,卷期：2010年116-22] Effectiveness of double umbilical cord blood (dUCB) grafts relative to conventional marrow and mobilized peripheral blood from related and unrelated donors has yet to be established. We studied 536 patients at the Fred H... Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects [作者：Melenhorst, JJ; Leen, AM; Bollard, CM; Quigley, MF; Price, DA; Rooney, CM; Brenner, MK; Barrett, AJ; Heslop, HE,期刊：Blood, 页码：4700-4702 , 文章类型： Article，,卷期：2010年116-22] Adoptive transfer of viral antigen-specific memory T cells can reconstitute antiviral immunity, but in a recent report a majority of virus-specific cytotoxic T-lymphocyte (CTL) linesshowedin vitro cross-reactivity agains... Functional divergence between 2 chemokines is conferred by single amino acid change [作者：Dubrac, A; Quemener, C; Lacazette, E; Lopez, D; Zanibellato, C; Wu, WG; Bikfalvi, A; Prats, H,期刊：Blood, 页码：4703-4711 , 文章类型： Article，,卷期：2010年116-22] CXCL4 and CXCL4L1 are 2 closely related CXC chemokines that exhibit potent anti-angiogenic activity. Because interactions with glycosaminoglycans play a crucial role in chemokines activity, we determined the binding para... von Willebrand factor promotes leukocyte extravasation [作者：Petri, B; Broermann, A; Li, H; Khandoga, AG; Zarbock, A; Krombach, F; Goerge, T; Schneider, SW; Jones, C; Nieswandt, B; Wild, MK; Vestweber, D,期刊：Blood, 页码：4712-4719 , 文章类型： Article，,卷期：2010年116-22] von Willebrand factor (VWF) is an important player in hemostasis but has also been suggested to promote inflammatory processes. Gene ablation of VWF causes a simultaneous defect in P-selectin expression making it difficu... Endothelial-derived PDGF-BB and HB-EGF coordinately regulate pericyte recruitment during vasculogenic tube assembly and stabilization [作者：Stratman, AN; Schwindt, AE; Malotte, KM; Davis, GE,期刊：Blood, 页码：4720-4730 , 文章类型： Article，,卷期：2010年116-22] Recently, we reported a novel system whereby human pericytes are recruited to endothelial cell (EC)-lined tubes in 3-dimensional (3D) extracellular matrices to stimulate vascular maturation including basement membrane ma... c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression [作者：Bianchi, E; Zini, R; Salati, S; Tenedini, E; Norfo, R; Tagliafico, E; Manfredini, R; Ferrari, S,期刊：Blood, 页码：E99-E110 , 文章类型： Article，,卷期：2010年116-22] The c-myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define its role during the hematopoietic lineage commitment, we silenced c-myb in human CD3... Establishment of the first World Health Organization International Genetic Reference Panel for quantitation of BCR-ABL mRNA [作者：White, HE; Matejtschuk, P; Rigsby, P; Gabert, J; Lin, F; Wang, YL; Branford, S; Muller, MC; Beaufils, N; Beillard, E; Colomer, D; Dvorakova, D; Ehrencrona, H; Goh, HG; El Housni, H; Jones, D; Kairisto, V; Kamel-Reid, S; Kim, DW; Langabeer, S; Ma, ESK; Press, RD; Romeo, G; Wang, LH; Zoi, K; Hughes, T; Saglio, G; Hochhaus, A; Goldman, JM; Metcalfe, P; Cross, NCP,期刊：Blood, 页码：E111-E117 , 文章类型： Article，,卷期：2010年116-22] Serial quantitation of BCR-ABL mRNA levels is an important indicator of therapeutic response for patients with chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia, but there is ...