- Structures of the Human GTPase MMAA and Vitamin B-12-dependent Methylmalonyl-CoA Mutase and Insight into Their Complex Formation
[作者:Froese, DS; Kochan, G; Muniz, JRC; Wu, XC; Gileadi, C; Ugochukwu, E; Krysztofinska, E; Gravel, RA; Oppermann, U; Yue, WW,期刊:Journal of Biological Chemistry, 页码:38204-38213 , 文章类型: Article,,卷期:2010年285-49]
- Vitamin B-12 (cobalamin, Cbl) is essential to the function of two human enzymes, methionine synthase (MS) and methylmalonyl-CoA mutase (MUT). The conversion of dietary Cbl to its cofactor forms, methyl-Cbl (MeCbl) for MS...
- Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy
[作者:Chen, D; Gao, F; Li, B; Wang, HF; Xu, YX; Zhu, CQ; Wang, GH,期刊:Journal of Biological Chemistry, 页码:38214-38223 , 文章类型: Article,,卷期:2010年285-49]
- Parkin is an E3 ubiquitin ligase that mediates the ubiquitination of protein substrates. The mutations in the parkin gene can lead to a loss of function of parkin and cause autosomal recessive juvenile onset parkinsonism...
- Endocannabinoids Prevent beta-Amyloid-mediated Lysosomal Destabilization in Cultured Neurons
[作者:Noonan, J; Tanveer, R; Klompas, A; Gowran, A; McKiernan, J; Campbell, VA,期刊:Journal of Biological Chemistry, 页码:38543-38554 , 文章类型: Article,,卷期:2010年285-49]
- Neuronal cell loss underlies the pathological decline in cognition and memory associated with Alzheimer disease (AD). Recently, targeting the endocannabinoid system in AD has emerged as a promising new approach to treatm...
- Human beta-Synuclein Rendered Fibrillogenic by Designed Mutations
[作者:Zibaee, S; Fraser, G; Jakes, R; Owen, D; Serpell, LC; Crowther, RA; Goedert, M,期刊:Journal of Biological Chemistry, 页码:38555-38567 , 文章类型: Article,,卷期:2010年285-49]
- Filamentous inclusions made of alpha-synuclein are found in nerve cells and glial cells in a number of human neurodegenerative diseases, including Parkinson disease, dementia with Lewy bodies, and multiple system atrophy...
- The Peptidomimetic CXCR4 Antagonist TC14012 Recruits beta-Arrestin to CXCR7 ROLES OF RECEPTOR DOMAINS
[作者:Gravel, S; Malouf, C; Boulais, PE; Berchiche, YA; Oishi, S; Fujii, N; Leduc, R; Sinnett, D; Heveker, N,期刊:Journal of Biological Chemistry, 页码:37939-37943 , 文章类型: Article,,卷期:2010年285-49]
- CXCR7 is an atypical chemokine receptor that signals through beta-arrestin in response to agonists without detectable activation of heterotrimeric G-proteins. Its cognate chemokine ligand CXCL12 also binds CXCR4, a chemo...
- A Conserved Aromatic Residue in the Autochaperone Domain of the Autotransporter Hbp Is Critical for Initiation of Outer Membrane Translocation
[作者:Soprova, Z; Sauri, A; van Ulsen, P; Tame, JRH; den Blaauwen, T; Jong, WSP; Luirink, J,期刊:Journal of Biological Chemistry, 页码:38224-38233 , 文章类型: Article,,卷期:2010年285-49]
- Autotransporters are bacterial virulence factors that share a common mechanism by which they are transported to the cell surface. They consist of an N-terminal passenger domain and a C-terminal beta-barrel, which has bee...
- Flexibility of the Thrombin-activatable Fibrinolysis Inhibitor Pro-domain Enables Productive Binding of Protein Substrates
[作者:Valnickova, Z; Sanglas, L; Arolas, JL; Petersen, SV; Schar, C; Otzen, D; Aviles, FX; Gomis-Ruth, FX; Enghild, JJ,期刊:Journal of Biological Chemistry, 页码:38243-38250 , 文章类型: Article,,卷期:2010年285-49]
- We have previously reported that thrombin-activatable fibrinolysis inhibitor (TAFI) exhibits intrinsic proteolytic activity toward large peptides. The structural basis for this observation was clarified by the crystal st...
- Kdo(2)-Lipid A, a TLR4-specific Agonist, Induces de Novo Sphingolipid Biosynthesis in RAW264.7 Macrophages, Which Is Essential for Induction of Autophagy
[作者:Sims, K; Haynes, CA; Kelly, S; Allegood, JC; Wang, E; Momin, A; Leipelt, M; Reichart, D; Glass, CK; Sullards, MC; Merrill, AH,期刊:Journal of Biological Chemistry, 页码:38568-38579 , 文章类型: Article,,卷期:2010年285-49]
Activation of RAW264.7 cells with a lipopolysaccharide specific for the TLR4 receptor, Kdo(2)-lipid A (KLA), causes a large increase in cellular sphingolipids, from 1.5 to 2.6 x 10(9) molecules per cell in 24 h, based...
- NMR Structure of the First Extracellular Domain of Corticotropin-releasing Factor Receptor 1 (ECD1-CRF-R1) Complexed with a High Affinity Agonist
[作者:Grace, CRR; Perrin, MH; Gulyas, J; Rivier, JE; Vale, WW; Riek, R,期刊:Journal of Biological Chemistry, 页码:38580-38589 , 文章类型: Article,,卷期:2010年285-49]
- The corticotropin-releasing factor (CRF) peptide hormone family members coordinate endocrine, behavioral, autonomic, and metabolic responses to stress and play important roles within the cardiovascular, gastrointestinal,...
- The Ecto-enzyme CD38 Is a Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Synthase That Couples Receptor Activation to Ca2+ Mobilization from Lysosomes in Pancreatic Acinar Cells
[作者:Cosker, F; Cheviron, N; Yamasaki, M; Menteyne, A; Lund, FE; Moutin, MJ; Galione, A; Cancela, JM,期刊:Journal of Biological Chemistry, 页码:38251-38259 , 文章类型: Article,,卷期:2010年285-49]
- Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca2+-mobilizing intracellular messenger and is linked to a variety of stimuli and cell surface receptors. However, the enzyme responsible for endog...
- Rsf-1, a Chromatin Remodeling Protein, Induces DNA Damage and Promotes Genomic Instability
[作者:Sheu, JJC; Guan, B; Choi, JH; Lin, A; Lee, CH; Hsiao, YT; Wang, TL; Tsai, FJ; Shih, IM,期刊:Journal of Biological Chemistry, 页码:38260-38269 , 文章类型: Article,,卷期:2010年285-49]
- Rsf-1 (HBXAP) has been reported as an amplified gene in human cancer, including the highly aggressive ovarian serous carcinoma. Rsf-1 protein interacts with SNF2H to form an ISWI chromatin remodeling complex, RSF. In thi...
- Plasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-ray Crystallography
[作者:Wilderman, PR; Shah, MB; Liu, T; Li, S; Hsu, S; Roberts, AG; Goodlett, DR; Zhang, QH; Woods, VL; Stout, CD; Halpert, JR,期刊:Journal of Biological Chemistry, 页码:38602-38611 , 文章类型: Article,,卷期:2010年285-49]
- Crystal structures of the xenobiotic metabolizing cytochrome P450 2B4 have demonstrated markedly different conformations in the presence of imidazole inhibitors or in the absence of ligand. However, knowledge of the plas...
- Structural Basis of Carbohydrate Recognition by Calreticulin
[作者:Kozlov, G; Pocanschi, CL; Rosenauer, A; Bastos-Aristizabal, S; Gorelik, A; Williams, DB; Gehring, K,期刊:Journal of Biological Chemistry, 页码:38612-38620 , 文章类型: Article,,卷期:2010年285-49]
- The calnexin cycle is a process by which glycosylated proteins are subjected to folding cycles in the endoplasmic reticulum lumen via binding to the membrane protein calnexin ( CNX) or to its soluble homolog calreticulin...
- The Mechanism of Microcin C Resistance Provided by the MccF Peptidase
[作者:Tikhonov, A; Kazakov, T; Semenova, E; Serebryakova, M; Vondenhoff, G; Van Aerschot, A; Reader, JS; Govorun, VM; Severinov, K,期刊:Journal of Biological Chemistry, 页码:37944-37952 , 文章类型: Article,,卷期:2010年285-49]
- The heptapeptide-nucleotide microcin C (McC) is a potent inhibitor of enteric bacteria growth. Inside a sensitive cell, McC is processed by aminopeptidases, which release a nonhydrolyzable aspartyl-adenylate, a strong in...
- The Role of cis Dimerization of Signal Regulatory Protein alpha (SIRP alpha) in Binding to CD47
[作者:Lee, WY; Weber, DA; Laur, O; Stowell, SR; Mccall, I; Andargachew, R; Cummings, RD; Parkos, CA,期刊:Journal of Biological Chemistry, 页码:37953-37963 , 文章类型: Article,,卷期:2010年285-49]
- Interaction of SIRP alpha with its ligand, CD47, regulates leukocyte functions, including transmigration, phagocytosis, oxidative burst, and cytokine secretion. Recent progress has provided significant insights into the ...
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