- Dkk1 and Wnt3 interact to control head morphogenesis in the mouse
[作者:Lewis, SL; Khoo, PL; De Young, RA; Steiner, K; Wilcock, C; Mukhopadhyay, M; Westphal, H; Jamieson, RV; Robb, L; Tam, PPL,期刊:Development, 页码:1791-1801 , 文章类型: Article,,卷期:2008年135-10]
- Loss of Dkk1 results in ectopic WNT/beta-catenin signalling activity in the anterior germ layer tissues and impairs cell movement in the endoderm of the mouse gastrula. The juxtaposition of the expression domains of Dkk1...
- Wt1 negatively regulates beta-catenin signaling during testis development
[作者:Chang, H; Gao, F; Guillou, F; Taketo, MM; Huff, V; Behringer, RR,期刊:Development, 页码:1875-1885 , 文章类型: Article,,卷期:2008年135-10]
- beta-Catenin, as an important effector of the canonical Wnt signaling pathway and as a regulator of cell adhesion, has been demonstrated to be involved in multiple developmental processes and tumorigenesis. beta-Catenin ...
- Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart
[作者:Goddeeris, MM; Rho, S; Petiet, A; Davenport, CL; Johnson, GA; Meyers, EN; Klingensmith, J,期刊:Development, 页码:1887-1895 , 文章类型: Article,,卷期:2008年135-10]
- Septation of the mammalian heart into four chambers requires the orchestration of multiple tissue progenitors. Abnormalities in this process can result in potentially fatal atrioventricular septation defects (AVSD). The ...
- Regulation of TGF-beta signalling by N-acetylgalactosaminyltransferase-like 1
[作者:Herr, P; Korniychuk, G; Yamamoto, Y; Grubisic, K; Oelgeschlager, M,期刊:Development, 页码:1813-1822 , 文章类型: Article,,卷期:2008年135-10]
- The TGF-alpha superfamily of secreted signalling molecules plays a pivotal role in the regulation of early embryogenesis, organogenesis and adult tissue homeostasis. Here we report the identification of Xenopus N-acetylg...
- Developmental origin of smooth muscle cells in the descending aorta in mice
[作者:Wasteson, P; Johansson, BR; Jukkola, T; Breuer, S; Akyurek, LM; Partanen, J; Lindahl, P,期刊:Development, 页码:1823-1832 , 文章类型: Article,,卷期:2008年135-10]
- Aortic smooth muscle cells (SMCs) have been proposed to derive from lateral plate mesoderm. It has further been suggested that induction of SMC differentiation is confined to the ventral side of the aorta, and that SMCs ...
- Wollknauel is required for embryo patterning and encodes the Drosophila ALG5 UDP-glucose: dolichyl-phosphate glucosyltransferase
[作者:Haecker, A; Bergman, M; Neupert, C; Moussian, B; Luschnig, S; Aebi, M; Mannervik, M,期刊:Development, 页码:1745-1749 , 文章类型: Article,,卷期:2008年135-10]
- N-linked glycosylation is a prevalent protein modification in eukaryotic cells. Although glycosylation plays an important role in cell signaling during development, a role for N-linked glycosylation in embryonic patterni...
- The Arabidopsis OBERON1 and OBERON2 genes encode plant homeodomain finger proteins and are required for apical meristem maintenance
[作者:Saiga, S; Furumizu, C; Yokoyama, R; Kurata, T; Sato, S; Kato, T; Tabata, S; Suzuki, M; Komeda, Y,期刊:Development, 页码:1751-1759 , 文章类型: Article,,卷期:2008年135-10]
- Maintenance of the stem cell population located at the apical meristems is essential for repetitive organ initiation during the development of higher plants. Here, we have characterized the roles of OBERON1 (OBE1) and it...
- FGF signalling controls formation of the apical sensory organ in the cnidarian Nematostella vectensis
[作者:Rentzsch, F; Fritzenwanker, JH; Scholz, CB; Technau, U,期刊:Development, 页码:1761-1769 , 文章类型: Article,,卷期:2008年135-10]
- Fibroblast growth factor (FGF) signalling regulates essential developmental processes in vertebrates and invertebrates, but its role during early metazoan evolution remains obscure. Here, we analyse the function of FGF s...
- Zic2 promotes axonal divergence at the optic chiasm midline by EphB1-dependent and -independent mechanisms
[作者:Garcia-Frigola, C; Carreres, MI; Vegar, C; Mason, C; Herrera, E,期刊:Development, 页码:1833-1841 , 文章类型: Article,,卷期:2008年135-10]
- Axons of retinal ganglion cells (RGCs) make a divergent choice at the optic chiasm to cross or avoid the midline in order to project to ipsilateral and contralateral targets, thereby establishing the binocular visual pat...
- SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation
[作者:Holmberg, J; Hansson, E; Malewicz, M; Sandberg, M; Perlmann, T; Lendahl, U; Muhr, J,期刊:Development, 页码:1843-1851 , 文章类型: Article,,卷期:2008年135-10]
- The preservation of a pool of neural precursors is a prerequisite for proper establishment and maintenance of a functional central nervous system (CNS). Both Notch signaling and SoxB1 transcription factors have been ascr...
- Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA
[作者:Matthews, HK; Marchant, L; Carmona-Fontaine, C; Kuriyama, S; Larrain, J; Holt, MR; Parsons, M; Mayor, R,期刊:Development, 页码:1771-1780 , 文章类型: Article,,卷期:2008年135-10]
- Directed cell migration is crucial for development, but most of our current knowledge is derived from in vitro studies. We analyzed how neural crest (NC) cells migrate in the direction of their target during embryonic de...
- MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex
[作者:Srinivasan, K; Roosa, J; Olsen, O; Lee, SH; Bredt, DS; McConnell, SK,期刊:Development, 页码:1781-1790 , 文章类型: Article,,卷期:2008年135-10]
- Apicobasal polarity plays an important role in regulating asymmetric cell divisions by neural progenitor cells (NPCs) in invertebrates, but the role of polarity in mammalian NPCs is poorly understood. Here, we characteri...
- CD41(+) cmyb(+) precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis
[作者:Bertrand, JY; Kim, AD; Teng, S; Traver, D,期刊:Development, 页码:1853-1862 , 文章类型: Article,,卷期:2008年135-10]
- Development of the vertebrate blood lineages is complex, with multiple waves of hematopoietic precursors arising in different embryonic locations. Monopotent, or primitive, precursors first give rise to embryonic macroph...
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