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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共12条记录   Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells [作者：Desch, P; Asslaber, D; Kern, D; Schnidar, H; Mangelberger, D; Alinger, B; Stoecher, M; Hofbauer, SW; Neureiter, D; Tinhofer, I; Aberger, F; Hartmann, TN; Greil, R,期刊：Oncogene, 页码：4885-4895 , 文章类型： Article，,卷期：2010年29-35] The Hedgehog (Hh) pathway regulates cell proliferation and survival and contributes to tumorigenesis. We investigated the expression and function of this pathway in B-cell chronic lymphocytic leukemia (CLL) cells and in ... Requirement of the histone demethylase LSD1 in Snail-mediated transcriptional repression during epithelial-mesenchymal transition [作者：Lin, T; Ponn, A; Hu, X; Law, BK; Lu, J,期刊：Oncogene, 页码：4896-4904 , 文章类型： Article，,卷期：2010年29-35] Epithelial-mesenchymal transition (EMT) has pivotal roles during embryonic development and carcinoma progression. Members of the Snai1 family of zinc finger transcription factors are central mediators of EMT and induce E... Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma [作者：Cooke, SL; Ng, CKY; Melnyk, N; Garcia, MJ; Hardcastle, T; Temple, J; Langdon, S; Huntsman, D; Brenton, JD,期刊：Oncogene, 页码：4905-4913 , 文章类型： Article，,卷期：2010年29-35] Resistance to chemotherapy in ovarian cancer is poorly understood. Evolutionary models of cancer predict that, following treatment, resistance emerges either because of outgrowth of an intrinsically resistant sub-clone o... miR-23b*targets proline oxidase, a novel tumor suppressor protein in renal cancer [作者：Liu, W; Zabirnyk, O; Wang, H; Shiao, YH; Nickerson, ML; Khalil, S; Anderson, LM; Perantoni, AO; Phang, JM,期刊：Oncogene, 页码：4914-4924 , 文章类型： Article，,卷期：2010年29-35] Proline oxidase (POX) is a novel mitochondrial tumor suppressor that can suppress proliferation and induce apoptosis through the generation of reactive oxygen species (ROS) and decreasing hypoxia-inducible factor (HIF) s... Cell transformation by v-Rel reveals distinct roles of AP-1 family members in Rel/NF-kappa B oncogenesis [作者：Liss, AS; Tiwari, R; Kralova, J; Bose, HR,期刊：Oncogene, 页码：4925-4937 , 文章类型： Article，,卷期：2010年29-35] Cell transformation by the v-rel oncogene is mediated by the aberrant expression of genes that are normally tightly regulated by other Rel/NF-kappa B family members. Although a number of genes inappropriately activated o... Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma [作者：Shang, X; Vasudevan, SA; Yu, Y; Ge, N; Ludwig, AD; Wesson, CL; Wang, K; Burlingame, SM; Zhao, YJ; Rao, PH; Lu, X; Russell, HV; Okcu, MF; Hicks, MJ; Shohet, JM; Donehower, LA; Nuchtern, JG; Yang, J,期刊：Oncogene, 页码：4938-4946 , 文章类型： Article，,卷期：2010年29-35] Chemoresistance is a major cause of treatment failure and poor outcome in neuroblastoma. In this study, we investigated the expression and function of dual-specificity phosphatase 26 (DUSP26), also known as mitogen-activ... Differential roles of ERK and Akt pathways in regulation of EGFR-mediated signaling and motility in prostate cancer cells [作者：Gan, Y; Shi, C; Inge, L; Hibner, M; Balducci, J; Huang, Y,期刊：Oncogene, 页码：4947-4958 , 文章类型： Article，,卷期：2010年29-35] Upregulation of epidermal growth factor receptor (EGFR) and subsequent increases in extracellular-regulated kinase (ERK) and Akt signaling are implicated in prostate cancer progression. Impaired endocytic downregulation ... Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth [作者：Wang, M; Hossain, MS; Tan, W; Coolman, B; Zhou, J; Liu, S; Casey, PJ,期刊：Oncogene, 页码：4959-4970 , 文章类型： Article，,卷期：2010年29-35] Inhibition of isoprenylcysteine carboxylmethyltransferase (Icmt), which catalyzes the final step in the post-translational C-terminal processing of prenylated proteins, suppresses tumor cell growth and induces cell death... MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers [作者：Imam, JS; Buddavarapu, K; Lee-Chang, JS; Ganapathy, S; Camosy, C; Chen, Y; Rao, MK,期刊：Oncogene, 页码：4971-4979 , 文章类型： Article，,卷期：2010年29-35] Homeobox genes encode transcription factors that are essential for normal development and are often dysregulated in cancers. The molecular mechanisms that cause their misregulation in cancers are largely unknown. In this... Tumor-suppressive microRNA-22 inhibits the transcription of E-box-containing c-Myc target genes by silencing c-Myc binding protein [作者：Xiong, J; Du, Q; Liang, Z,期刊：Oncogene, 页码：4980-4988 , 文章类型： Article，,卷期：2010年29-35] Oncogenic c-Myc has been described to modulate the expression of a subset of microRNAs (miRNAs), which include miR-22; however, the mechanism through which a miRNA controls c-Myc activity remains unclear. Here we report ... The ubiquitous nature of cancer: the role of the SCFFbw7 complex in development and transformation [作者：Crusio, KM; King, B; Reavie, LB; Aifantis, I,期刊：Oncogene, 页码：4865-4873 , 文章类型： Review，,卷期：2010年29-35] The ubiquitin-proteasome system (UPS) is a multi-subunit pathway that allows for ubiquitin modification of proteins and leads to either degradation or other non-proteolytic processes such as trafficking or transcriptiona... From smoking to lung cancer: the CHRNA5/A3/B4 connection [作者：Improgo, MRD; Scofield, MD; Tapper, AR; Gardner, PD,期刊：Oncogene, 页码：4874-4884 , 文章类型： Review，,卷期：2010年29-35] Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that modulate key physiological processes ranging from neurotransmission to cancer signaling. These receptors are activated by the neurotransmitter...