- Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+cells
[作者：Paggetti, J; Largeot, A; Aucagne, R; Jacquel, A; Lagrange, B; Yang, XJ; Solary, E; Bastie, JN; Delva, L,期刊：Oncogene, 页码：5019-5031 , 文章类型： Article，,卷期：2010年29-36]
- MOZ and MLL, encoding a histone acetyltransferase (HAT) and a histone methyltransferase, respectively, are targets for recurrent chromosomal translocations found in acute myeloblastic or lymphoblastic leukemia. In MOZ (M...
- ARRDC3 suppresses breast cancer progression by negatively regulating integrin beta 4
[作者：Draheim, KM; Chen, HB; Tao, Q; Moore, N; Roche, M; Lyle, S,期刊：Oncogene, 页码：5032-5047 , 文章类型： Article，,卷期：2010年29-36]
- Large-scale genetic analyses of human tumor samples have been used to identify novel oncogenes, tumor suppressors and prognostic factors, but the functions and molecular interactions of many individual genes have not bee...
- TRAIL treatment provokes mutations in surviving cells
[作者：Lovric, MM; Hawkins, CJ,期刊：Oncogene, 页码：5048-5060 , 文章类型： Article，,卷期：2010年29-36]
- Chemotherapy and radiotherapy commonly damage DNA and trigger p53-dependent apoptosis through intrinsic apoptotic pathways. Two unfortunate consequences of this mechanism are resistance due to blockade of p53 or intrinsi...
- Dichotomy in NF-kappa B signaling and chemoresistance in immunoglobulin variable heavy-chain-mutated versus unmutated CLL cells upon CD40/TLR9 triggering
[作者：Tromp, JM; Tonino, SH; Elias, JA; Jaspers, A; Luijks, DM; Kater, AP; van Lier, RAW; van Oers, MHJ; Eldering, E,期刊：Oncogene, 页码：5071-5082 , 文章类型： Article，,卷期：2010年29-36]
- Chronic lymphocytic leukemia (CLL) cells circulating in peripheral blood (PB) differ from the leukemic fraction in lymph nodes (LNs) with respect to cell division and drug sensitivity. CD40 stimulation of PB CLL cells in...
- Transcriptional factor HBP1 targets P16(INK4A), upregulating its expression and consequently is involved in Ras-induced premature senescence
[作者：Li, H; Wang, W; Liu, X; Paulson, KE; Yee, AS; Zhang, X,期刊：Oncogene, 页码：5083-5094 , 文章类型： Article，,卷期：2010年29-36]
- Oncogene-mediated premature senescence has emerged as a potential tumor-suppressive mechanism in early cancer transitions. Many studies showed that Ras and p38 mitogen-activated protein kinase (MAPK) participate in prema...
- Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas
[作者：Bartkova, J; Hamerlik, P; Stockhausen, MT; Ehrmann, J; Hlobilkova, A; Laursen, H; Kalita, O; Kolar, Z; Poulsen, HS; Broholm, H; Lukas, J; Bartek, J,期刊：Oncogene, 页码：5095-5102 , 文章类型： Article，,卷期：2010年29-36]
- Malignant gliomas, the deadliest of brain neoplasms, show rampant genetic instability and resistance to genotoxic therapies, implicating potentially aberrant DNA damage response (DDR) in glioma pathogenesis and treatment...
- The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2
[作者：Zeng, X; Shaikh, FY; Harrison, MK; Adon, AM; Trimboli, AJ; Carroll, KA; Sharma, N; Timmers, C; Chodosh, LA; Leone, G; Saavedra, HI,期刊：Oncogene, 页码：5103-5112 , 文章类型： Article，,卷期：2010年29-36]
- Centrosome amplification (CA) contributes to carcinogenesis by generating aneuploidy. Elevated frequencies of CA in most benign breast lesions and primary tumors suggest a causative role for CA in breast cancers. Clearly...
- The unexpected role of lymphotoxin beta receptor signaling in carcinogenesis: from lymphoid tissue formation to liver and prostate cancer development
[作者：Wolf, MJ; Seleznik, GM; Zeller, N; Heikenwalder, M,期刊：Oncogene, 页码：5006-5018 , 文章类型： Review，,卷期：2010年29-36]
- The cytokines lymphotoxin (LT) alpha, beta and their receptor (LT beta R) belong to the tumor necrosis factor (TNF) superfamily, whose founder-TNF alpha-was initially discovered due to its tumor necrotizing activity. LT ...
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