- K-Ras4B phosphorylation at Ser181 is inhibited by calmodulin and modulates K-Ras activity and function
[作者：Alvarez-Moya, B; Lopez-Alcala, C; Drosten, M; Bachs, O; Agell, N,期刊：Oncogene, 页码：5911-5922 , 文章类型： Article，,卷期：2010年29-44]
- Fine tuning of Ras activity is widely known as a mechanism to induce different cellular responses. Recently, we have shown that calmodulin (CaM) binds to K-Ras and that K-Ras phosphorylation inhibits its interaction with...
- Transcriptional regulation of Wnt inhibitory factor-1 by Miz-1/c-Myc
[作者：Licchesi, JDF; Van Neste, L; Tiwari, VK; Cope, L; Lin, X; Baylin, SB; Herman, JG,期刊：Oncogene, 页码：5923-5934 , 文章类型： Article，,卷期：2010年29-44]
- The Wnt signaling pathway is capable of self-regulation through positive and negative feedback mechanisms. For example, the oncoprotein c-Myc, which is upregulated by Wnt signaling activity, participates in a positive fe...
- Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activity
[作者：Giglio, S; Mancini, F; Pellegrino, M; Di Conza, G; Puxeddu, E; Sacchi, A; Pontecorvi, A; Moretti, F,期刊：Oncogene, 页码：5935-5945 , 文章类型： Article，,卷期：2010年29-44]
- Under basal growth conditions, p53 function is tightly controlled by the members of MDM family, MDM2 and MDM4. The Mdm2 gene codes, in addition to the full-length p90(MDM2), for a short protein, p76(MDM2) that lacks the ...
- Sumoylation of ING2 regulates the transcription mediated by Sin3A
[作者：Ythier, D; Larrieu, D; Binet, R; Binda, O; Brambilla, C; Gazzeri, S; Pedeux, R,期刊：Oncogene, 页码：5946-5956 , 文章类型： Article，,卷期：2010年29-44]
- ING2 (inhibitor of growth 2) is a candidate tumor-suppressor gene involved in cell cycle control, apoptosis and senescence. Although the functions of ING2 within the chromatin remodeling complex Sin3A/histone deacetylase...
- Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects
[作者：Marshall, GM; Gherardi, S; Xu, N; Neiron, Z; Trahair, T; Scarlett, CJ; Chang, DK; Liu, PY; Jankowski, K; Iraci, N; Haber, M; Norris, MD; Keating, J; Sekyere, E; Jonquieres, G; Stossi, F; Katzenellenbogen, BS; Biankin, AV; Perini, G; Liu, T,期刊：Oncogene, 页码：5957-5968 , 文章类型： Article，,卷期：2010年29-44]
- Myc oncoproteins and histone deacetylases (HDACs) modulate gene transcription and enhance cancer cell proliferation, and HDAC inhibitors are among the most promising new classes of anticancer drugs. Here, we show that N-...
- EMX2 is epigenetically silenced and suppresses growth in human lung cancer
[作者：Okamoto, J; Hirata, T; Chen, Z; Zhou, HM; Mikami, I; Li, H; Beltran, A; Johansson, M; Coussens, LM; Clement, G; Shi, Y; Zhang, F; Koizumi, K; Shimizu, K; Jablons, D; He, B,期刊：Oncogene, 页码：5969-5975 , 文章类型： Article，,卷期：2010年29-44]
- Lung cancer is a common cancer and the leading cause of cancer-related death worldwide. Aberrant activation of WNT signaling is implicated in lung carcinogenesis. EMX2, a human homologue of the Drosophila empty spiracles...
- AP1 factor inactivation in the suprabasal epidermis causes increased epidermal hyperproliferation and hyperkeratosis but reduced carcinogen-dependent tumor formation
[作者：Rorke, EA; Adhikary, G; Jans, R; Crish, JF; Eckert, RL,期刊：Oncogene, 页码：5873-5882 , 文章类型： Article，,卷期：2010年29-44]
- Activator protein one (AP1) (jun/fos) factors comprise a family of transcriptional regulators (c-jun, junB, junD, c-fos, FosB, Fra-1 and Fra-2) that are key controllers of epidermal keratinocyte survival and differentiat...
- The protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigenesis
[作者：Liu, Y; Chen, N; Cui, X; Zheng, X; Deng, L; Price, S; Karantza, V; Minden, A,期刊：Oncogene, 页码：5883-5894 , 文章类型： Article，,卷期：2010年29-44]
- The Pak4 serine/threonine kinase is highly expressed in many cancer cell lines and human tumors. Although several studies have addressed the role for Pak4 in transformation of fibroblasts, most human cancers are epitheli...
- The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization
[作者：Titz, B; Low, T; Komisopoulou, E; Chen, SS; Rubbi, L; Graeber, TG,期刊：Oncogene, 页码：5895-5910 , 文章类型： Article，,卷期：2010年29-44]
- BCR-ABL1 is a fusion tyrosine kinase, which causes multiple types of leukemia. We used an integrated proteomic approach that includes label-free quantitative protein complex and phosphorylation profiling by mass spectrom...
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