- Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol
[作者:Radulescu, S; Ridgway, RA; Appleton, P; Kroboth, K; Patel, S; Woodgett, J; Taylor, S; Nathke, IS; Sansom, OJ,期刊:Oncogene, 页码:6418-6427 , 文章类型: Article,,卷期:2010年29-49]
- Mutations in the adenomatous polyposis coli (APC) tumour suppressor are the key initiating event of colorectal cancer. Although the control of WNT signalling is well established as a central tumour-suppressive function, ...
- An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs
[作者:Sheridan, C; Brumatti, G; Elgendy, M; Brunet, M; Martin, SJ,期刊:Oncogene, 页码:6428-6441 , 文章类型: Article,,卷期:2010年29-49]
- Cisplatin is a widely used cancer chemotherapeutic that promotes DNA damage-associated apoptosis. Although platinum compounds are known to form DNA adducts and provoke DNA damage, the molecular mechanism of cisplatin-ind...
- PRIMA-1(MET)/APR-246 targets mutant forms of p53 family members p63 and p73
[作者:Rokaeus, N; Shen, J; Eckhardt, I; Bykov, VJN; Wiman, KG; Wilhelm, MT,期刊:Oncogene, 页码:6442-6451 , 文章类型: Article,,卷期:2010年29-49]
- The low molecular weight compound PRIMA-1 and the structural analog PRIMA-1(MET), also named APR-246, reactivate mutant p53 through covalent binding to the core domain and induce apoptosis in tumor cells. Here, we asked ...
- Mammary-derived growth inhibitor (MDGI) interacts with integrin alpha-subunits and suppresses integrin activity and invasion
[作者:Nevo, J; Mai, A; Tuomi, S; Pellinen, T; Pentikainen, OT; Heikkila, P; Lundin, J; Joensuu, H; Bono, P; Ivaska, J,期刊:Oncogene, 页码:6452-6463 , 文章类型: Article,,卷期:2010年29-49]
- The majority of mortality associated with cancer is due to formation of metastases from the primary tumor. Adhesion mediated by different integrin heterodimers has an important role during cell migration and invasion. Pr...
- Epigenetic inactivation of T-box transcription factor 5, a novel tumor suppressor gene, is associated with colon cancer
[作者:Yu, J; Ma, X; Cheung, KF; Li, X; Tian, L; Wang, S; Wu, CW; Wu, WKK; He, M; Wang, M; Ng, SSM; Sung, JJY,期刊:Oncogene, 页码:6464-6474 , 文章类型: Article,,卷期:2010年29-49]
- T-box transcription factor 5 (TBX5) is a member of a phylogenetically conserved family of genes involved in the regulation of developmental processes. The function of TBX5 in cancer development is largely unclear. We ide...
- The RNA helicase p68 modulates expression and function of the Delta 133 isoform(s) of p53, and is inversely associated with Delta 133p53 expression in breast cancer
[作者:Moore, HC; Jordan, LB; Bray, SE; Baker, L; Quinlan, PR; Purdie, CA; Thompson, AM; Bourdon, JC; Fuller-Pace, FV,期刊:Oncogene, 页码:6475-6484 , 文章类型: Article,,卷期:2010年29-49]
- The RNA helicase p68 is a potent co-activator of p53-dependent transcription in response to DNA damage. Previous independent studies have indicated that p68 and the Delta 133p53 isoforms, which modulate the function of f...
|