- ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability
[作者:Goetz, EM; Shankar, B; Zou, Y; Morales, JC; Luo, X; Araki, S; Bachoo, R; Mayo, LD; Boothman, DA,期刊:Oncogene, 页码:3745-3754 , 文章类型: Article,,卷期:2011年30-35]
- Secretory clusterin (sCLU) is a stress-induced, prosurvival glycoprotein elevated in early-stage cancers, in particular in APC/Min-defective colon cancers. sCLU is upregulated after exposure to various cytotoxic agents, ...
- Type IV collagen-initiated signals provide survival and growth cues required for liver metastasis
[作者:Burnier, JV; Wang, N; Michel, RP; Hassanain, M; Li, S; Lu, Y; Metrakos, P; Antecka, E; Burnier, MN; Ponton, A; Gallinger, S; Brodt, P,期刊:Oncogene, 页码:3766-3783 , 文章类型: Article,,卷期:2011年30-35]
- The liver is a major site of metastasis for human malignancies, yet the factors that regulate tumor cell survival and growth in this organ remain elusive. Previously, we reported that M-27(IGF-IR) murine lung carcinoma c...
- Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer
[作者:Gill, RK; Yang, SH; Meerzaman, D; Mechanic, LE; Bowman, ED; Jeon, HS; Chowdhuri, SR; Shakoori, A; Dracheva, T; Hong, KM; Fukuoka, J; Zhang, JH; Harris, CC; Jen, J,期刊:Oncogene, 页码:3784-3791 , 文章类型: Article,,卷期:2011年30-35]
- LKB1/STK11 is a tumor suppressor and a negative regulator of mammalian target of rapamycin signaling. It is inactivated in 30% of lung cancer cell lines but only 5-15% of primary lung adenocarcinomas. There is evidence t...
- TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1
[作者:Jin, HO; Seo, SK; Kim, YS; Woo, SH; Lee, KH; Yi, JY; Lee, SJ; Choe, TB; Lee, JH; An, S; Hong, SI; Park, IC,期刊:Oncogene, 页码:3792-3801 , 文章类型: Article,,卷期:2011年30-35]
- The mammalian target of rapamycin (mTOR) is a highly conserved serine-threonine kinase activated in response to growth factors and nutrients. Because of frequent dysregulation of the mTOR signaling pathway in diverse hum...
- Oncogenic role of EAPII in lung cancer development and its activation of the MAPK-ERK pathway
[作者:Li, C; Fan, S; Owonikoko, TK; Khuri, FR; Sun, SY; Li, R,期刊:Oncogene, 页码:3802-3812 , 文章类型: Article,,卷期:2011年30-35]
- Cancer progression involves multiple complex and interdependent steps, including progressive proliferation, angiogenesis and metastases. The complexity of these processes requires a comprehensive elucidation of the integ...
- Dual-specificity phosphatase DUSP6 has tumor-promoting properties in human glioblastomas
[作者:Messina, S; Frati, L; Leonetti, C; Zuchegna, C; Di Zazzo, E; Calogero, A; Porcellini, A,期刊:Oncogene, 页码:3813-3820 , 文章类型: Article,,卷期:2011年30-35]
- Dual-specificity phosphatase 6 (DUSP6, mitogen-activated protein kinase (MAPK) phosphatase 3 or PYST1) dephosphorylates phosphotyrosine and phosphothreonine residues on extracellular signal-regulated kinase (ERK1/2; MAPK...
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