- RNA interference-mediated knockdown of p21(WAF1) enhances anti-tumor cell activity of oncolytic adenoviruses
[作者:Shiina, M; Lacher, MD; Christian, C; Korn, WM,期刊:Cancer gene therapy, 页码:810-819 , 文章类型: Article,,卷期:2009年16-11]
The ability of oncolytic adenoviruses to replicate in and lyse cancer cells offers a potential therapeutic approach. However, selectivity and efficacy of adenovirus replication need to be improved. In this study, we p...
- Lentiviruses with trastuzumab bound to their envelopes can target and kill prostate cancer cells
[作者:Zhang, KX; Moussavi, M; Kim, C; Chow, E; Chen, IS; Fazli, L; Jia, W; Rennie, PS,期刊:Cancer gene therapy, 页码:820-831 , 文章类型: Article,,卷期:2009年16-11]
- In this study, we took advantage of the overexpression of human epidermal growth factor receptor 2 (HER-2) in prostate cancers to design lentiviruses with modified envelope proteins that bind antibodies to specific cell-...
- Cytotoxicity of adenoviruses expressing the wild-type p53 gene to esophageal carcinoma cells is linked with the CAR expression level and indirectly with the endogenous p53 status
[作者:Ma, G; Kawamura, K; Li, Q; Suzuki, N; Liang, M; Namba, M; Shimada, H; Tagawa, M,期刊:Cancer gene therapy, 页码:832-840 , 文章类型: Article,,卷期:2009年16-11]
- We examined cytotoxic effects of adenoviruses (Ad) expressing the p53 gene (Ad-p53) in nine human esophageal carcinoma cell lines with respect to the Ad receptor expression and the endogenous p53 gene status. Ad-p53-medi...
- Combination of human tumor necrosis factor-alpha (hTNF-alpha) gene delivery with gemcitabine is effective in models of pancreatic cancer
[作者:Murugesan, SR; King, CR; Osborn, R; Fairweather, WR; O'Reilly, EM; Thornton, MO; Wei, LL,期刊:Cancer gene therapy, 页码:841-847 , 文章类型: Article,,卷期:2009年16-11]
- Pancreatic adenocarcinoma is an aggressive and highly lethal malignancy. Currently, gemcitabine is commonly used in patients with pancreatic cancer. However, the life expectancy of pancreatic cancer patients remains poor...
- Adenovirus delivery of human CD40 ligand gene confers direct therapeutic effects on carcinomas
[作者:Vardouli, L; Lindqvist, C; Vlahou, K; Loskog, ASI; Eliopoulos, AG,期刊:Cancer gene therapy, 页码:848-860 , 文章类型: Article,,卷期:2009年16-11]
- CD40, a tumor necrosis factor receptor family member, is an emerging target for cancer therapy being best appreciated as an important regulator of the anti-tumor immune response. In this study, we report the development ...
- Novel strategies to augment genetically delivered immunotoxin molecular therapy for cancer therapy
[作者:Liu, X; Wu, J; Zhang, S; Li, C; Huang, Q,期刊:Cancer gene therapy, 页码:861-872 , 文章类型: Article,,卷期:2009年16-11]
- Immunotoxin therapy is a promising molecular cancer treatment strategy. Its main advantage is seletive cytotoxicity towards tumor cells and minimal toxicity in normal tissues. However, a short half-life and rapid clearan...
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