- Development and Use of Methylnaltrexone, a Peripherally Acting Opioid Antagonist, to Treat Side Effects Related to Opioid Use
[作者:Yuan, CS; Foss, JF; Williams, WA; Moss, J,期刊:Drug Development Research, 页码:403-416 , 文章类型: Article,,卷期:2009年70-6]
- Opioid medications are used extensively as potent analgesics for treating moderate to severe pain. Although opioids offer reliable pain relief, their use is associated with a number of adverse effects, especially constip...
- Protective Effect of Curcumin, a Curcuma longa Constituent, in Early Colonic Inflammation in Rats
[作者:Sanchez-Calvo, JM; Villegas, I; Sanchez-Fidalgo, S; Camacho-Barquero, L; Talero, E; Motilva, V; de la Lastra, CA,期刊:Drug Development Research, 页码:425-437 , 文章类型: Article,,卷期:2009年70-6]
- Curcumin, a polyphenol derived from the plant, Curcuma longa, has a variety of pharmacological effects, including chemotherapeutic, anti-inflammatory, antiangiogenic, and antioxidant activities. To gain a better understa...
- 3D-QSAR Studies of Cytotoxic Heterocyclic Quinones Using Calculated Reduction Potential
[作者:Lee, Y; Kim, S; Rhee, HK; Doh, KE; Park, J; Lee, CO; Choi, S; Choo, HYP,期刊:Drug Development Research, 页码:438-444 , 文章类型: Article,,卷期:2009年70-6]
- Most quinones with 2-4 fused aromatic rings exhibit cytostatic activity via DNA intercalation that causes enzyme blockade and reading errors during the replication process. The redox activity of quinones plays a role in ...
- Effect of CJX2, an Amlodipine Derivative, Combined With Verapamil on P-Glycoprotein Efflux Function In Vitro
[作者:Ji, BS; Li, M; He, L,期刊:Drug Development Research, 页码:445-449 , 文章类型: Article,,卷期:2009年70-6]
- In an effort to inhibit P-glycoprotein (P-gp) efflux function with greater activity and less side effects, the combined effect of CJX2 and verapamil (Ver) was evaluated isobolographically in fixed ratio combinations of 1...
- Synergistic Interaction Between Tramadol and Dipyrone in Thermal Paw Stimulation Model in the Rat
[作者:Rodriguez-Silverio, J; Arrieta, J; Flores-Murrieta, FJ,期刊:Drug Development Research, 页码:450-454 , 文章类型: Article,,卷期:2009年70-6]
- Dipyrone, also known as metamizol, and tramadol are drugs that are widely used for the treatment of pain; however, side effects can limit their use. As dipyrone and tramadol produce side effects that are dose dependent, ...
- The Evaluation of a Biodegradable Dental Chip Containing Chlorhexidine in Chitosan Base as a Targeted Drug Delivery in the Management of Chronic Periodontitis in Patients (vol 70, pg 395, 2009)
[作者:Jothi, MV; Bhat, KM; Pratibha, PK; Kumar, R; Bhat, GS,期刊:Drug Development Research, 页码:455-455 , 文章类型: Correction,,卷期:2009年70-6]
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