- AP1 is essential for generation of autophagosomes from the trans-Golgi network
[作者:Guo, YJ; Chang, CM; Huang, R; Liu, B; Bao, L; Liu, W,期刊:Journal of cell science, 页码:1706-1715 , 文章类型: Article,,卷期:2012年125-7]
- Despite recent advances in understanding the functions of autophagy in developmental and pathological conditions, the underlying mechanism of where and how autophagosomal structures acquire membrane remains enigmatic. He...
- The 14-3-3 gene par-5 is required for germline development and DNA damage response in Caenorhabditis elegans
[作者:Aristizabal-Corrales, D; Fontrodona, L; Porta-de-la-Riva, M; Guerra-Moreno, A; Ceron, J; Schwartz, S,期刊:Journal of cell science, 页码:1716-1726 , 文章类型: Article,,卷期:2012年125-7]
- 14-3-3 proteins have been extensively studied in organisms ranging from yeast to mammals and are associated with multiple roles, including fundamental processes such as the cell cycle, apoptosis and the stress response, ...
- miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression
[作者:Yang, DH; Li, T; Wang, Y; Tang, YJ; Cui, HJ; Tang, Y; Zhang, XJ; Chen, DG; Shen, N; Le, WD,期刊:Journal of cell science, 页码:1673-1682 , 文章类型: Article,,卷期:2012年125-7]
- Although it is well established that embryonic stem (ES) cells have the potential to differentiate into dopamine neurons, the molecular basis of this process, particularly the role of microRNAs (miRNAs), remains largely ...
- Myf5 haploinsufficiency reveals distinct cell fate potentials for adult skeletal muscle stem cells
[作者:Gayraud-Morel, B; Chretien, F; Jory, A; Sambasivan, R; Negroni, E; Flamant, P; Soubigou, G; Coppee, JY; Di Santo, J; Cumano, A; Mouly, V; Tajbakhsh, S,期刊:Journal of cell science, 页码:1738-1749 , 文章类型: Article,,卷期:2012年125-7]
- Skeletal muscle stem cell fate in adult mice is regulated by crucial transcription factors, including the determination genes Myf5 and Myod. The precise role of Myf5 in regulating quiescent muscle stem cells has remained...
- The IplA Ca2+ channel of Dictyostelium discoideum is necessary for chemotaxis mediated through Ca2+, but not through cAMP, and has a fundamental role in natural aggregation
[作者:Lusche, DF; Wessels, D; Scherer, A; Daniels, K; Kuhl, S; Soll, DR,期刊:Journal of cell science, 页码:1770-1783 , 文章类型: Article,,卷期:2012年125-7]
- During aggregation of Dictyostelium discoideum, nondissipating, symmetrical, outwardly moving waves of cAMP direct cells towards aggregation centers. It has been assumed that the spatial and temporal characteristics of t...
- The metastasis gene NEDD9 product acts through integrin beta 3 and Src to promote mesenchymal motility and inhibit amoeboid motility
[作者:Ahn, J; Sanz-Moreno, V; Marshall, CJ,期刊:Journal of cell science, 页码:1814-1826 , 文章类型: Article,,卷期:2012年125-7]
- Neural precursor expressed, developmentally down-regulated 9 (NEDD9), a member of the Cas family of signal transduction molecules, is amplified at the genetic level in melanoma, and elevated expression levels have been s...
- Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart
[作者:Zissimopoulos, S; Seifan, S; Maxwell, C; Williams, AJ; Lai, FA,期刊:Journal of cell science, 页码:1759-1769 , 文章类型: Article,,卷期:2012年125-7]
- The FK506-binding proteins (FKBP12 and FKBP12.6; also known as FKBP1A and FKBP1B, respectively) are accessory subunits of the ryanodine receptor (RyR) Ca2+ release channel. Aberrant RyR2-FKBP12.6 interactions have been p...
- Plo1 phosphorylates Dam1 to promote chromosome bi-orientation in fission yeast
[作者:Buttrick, GJ; Lancaster, TC; Meadows, JC; Millar, JBA,期刊:Journal of cell science, 页码:1645-1651 , 文章类型: Article,,卷期:2012年125-7]
- The fungal-specific heterodecameric outer kinetochore DASH complex facilitates the interaction of kinetochores with spindle microtubules. In budding yeast, where kinetochores bind a single microtubule, the DASH complex i...
- TOR signaling regulates planarian stem cells and controls localized and organismal growth
[作者:Peiris, TH; Weckerle, F; Ozamoto, E; Ramirez, D; Davidian, D; Garcia-Ojeda, ME; Oviedo, NJ,期刊:Journal of cell science, 页码:1657-1665 , 文章类型: Article,,卷期:2012年125-7]
- Target of Rapamycin (TOR) controls an evolutionarily conserved signaling pathway that modulates cellular growth and division by sensing levels of nutrients, energy and stress. As such, TOR signaling is a crucial componen...
- Dystrophin-compromised sarcoglycan-delta-knockout diaphragm requires full wild-type embryonic stem cell reconstitution for correction
[作者:Vitale, JM; Schneider, JS; Beck, AJ; Zhao, QS; Chang, C; Gordan, R; Michaels, J; Bhaumik, M; Fraidenraich, D,期刊:Journal of cell science, 页码:1807-1813 , 文章类型: Article,,卷期:2012年125-7]
- Limb-girdle muscular dystrophy-2F (LGMD-2F) is an incurable degenerative muscle disorder caused by a mutation in the sarcoglycan-delta (SG delta)-encoding gene (SGCD in humans). The lack of SG delta results in the comple...
- Prolonged seizure activity impairs mitochondrial bioenergetics and induces cell death
[作者:Kovac, S; Domijan, AM; Walker, MC; Abramov, AY,期刊:Journal of cell science, 页码:1796-1806 , 文章类型: Article,,卷期:2012年125-7]
- The mechanisms underlying neuronal death following excessive activity such as occurs during prolonged seizures are unclear, but mitochondrial dysfunction has been hypothesised to play a role. Here, we tested this with fl...
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