- Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation
[作者：Wheeler, SE; Suzuki, S; Thomas, SM; Sen, M; Leeman-Neill, RJ; Chiosea, SI; Kuan, CT; Bigner, DD; Gooding, WE; Lai, SY; Grandis, JR,期刊：Oncogene, 页码：5135-5145 , 文章类型： Article，,卷期：2010年29-37]
- Epidermal growth factor receptor (EGFR) is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC) where aberrant signaling downstream of this receptor contributes to tumor growth. EGFR variant III (EGF...
- AZGP1 is a tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-beta-mediated ERK signaling
[作者：Kong, B; Michalski, CW; Hong, X; Valkovskaya, N; Rieder, S; Abiatari, I; Streit, S; Erkan, M; Esposito, I; Friess, H; Kleeff, J,期刊：Oncogene, 页码：5146-5158 , 文章类型： Article，,卷期：2010年29-37]
- Epithelial-to-mesenchymal transdifferentiation (EMT) mediated by transforming growth factor-beta (TGF-beta) signaling leads to aggressive cancer progression. In this study, we identified zinc-alpha 2-glycoprotein (AZGP1,...
- Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis
[作者：Tessema, M; Klinge, DM; Yingling, CM; Do, K; Van Neste, L; Belinsky, SA,期刊：Oncogene, 页码：5159-5170 , 文章类型： Article，,卷期：2010年29-37]
- Chemokines are important regulators of directional cell migration and tumor metastasis. A genome-wide transcriptome array designed to uncover novel genes silenced by methylation in lung cancer identified the CXCsubfamily...
- Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers
[作者：Caron, C; Lestrat, C; Marsal, S; Escoffier, E; Curtet, S; Virolle, V; Barbry, P; Debernardi, A; Brambilla, C; Brambilla, E; Rousseaux, S; Khochbin, S,期刊：Oncogene, 页码：5171-5181 , 文章类型： Article，,卷期：2010年29-37]
- Cancer cells frequently express genes normally active in male germ cells. ATAD2 is one of them encoding a conserved factor harbouring an AAA type ATPase domain and a bromodomain. We show here that ATAD2 is highly express...
- H1047R phosphatidylinositol 3-kinase mutant enhances HER2-mediated transformation by heregulin production and activation of HER3
[作者：Chakrabarty, A; Rexer, BN; Wang, SE; Cook, RS; Engelman, JA; Arteaga, CL,期刊：Oncogene, 页码：5193-5203 , 文章类型： Article，,卷期：2010年29-37]
- Hyperactivation of phosphatidylinositol-3 kinase (PI3K) can occur as a result of somatic mutations in PIK3CA, the gene encoding the p110 alpha subunit of PI3K. The HER2 oncogene is amplified in 25% of all breast cancers ...
- Why is p53-inducible gene 3 rarely affected in cancer?
[作者：Kotsinas, A; Pateras, IS; Galanos, PS; Karamouzis, MV; Sfikakis, PP; Gorgoulis, VG,期刊：Oncogene, 页码：5220-5220 , 文章类型： Letter，,卷期：2010年29-37]
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- Reactivation of epigenetically silenced HER4/ERBB4 results in apoptosis of breast tumor cells
[作者：Das, PM; Thor, AD; Edgerton, SM; Barry, SK; Chen, DF; Jones, FE,期刊：Oncogene, 页码：5214-5219 , 文章类型： Article，,卷期：2010年29-37]
- Experimental and clinical data support a growth inhibitory role for HER4 in breast cancer. Clinically HER4 expression is extinguished during breast tumorigenesis supporting a tumor suppressor function for HER4, however, ...
- p53 isoforms gain functions
[作者：Olivares-Illana, V; Fahraeus, R,期刊：Oncogene, 页码：5113-5119 , 文章类型： Review，,卷期：2010年29-37]
- Many different cell stress pathways converge on p53 to induce a number of distinct cell biological responses such as G1 or G2 arrest, senescence or apoptosis. One of the outstanding questions with regard to p53 is how th...
- Drug resistance in mutant FLT3-positive AML
[作者：Weisberg, E; Sattler, M; Ray, A; Griffin, JD,期刊：Oncogene, 页码：5120-5134 , 文章类型： Review，,卷期：2010年29-37]
- Mutant Fms-Like Tyrosine kinase-3 (FLT3), which is expressed in the leukemic cells of a subpopulation of acute myeloid leukemia (AML) patients, represents an attractive target for the therapy of AML. There are several FL...
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