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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共10条记录   A novel concept in antiangiogenic and antitumoral therapy: multitarget destabilization of short-lived mRNAs by the zinc finger protein ZFP36L1 [作者：Planel, S; Salomon, A; Jalinot, P; Feige, JJ; Cherradi, N,期刊：Oncogene, 页码：5989-6003 , 文章类型： Article，,卷期：2010年29-45] Angiogenesis inhibitors have shown clinical benefits in patients with advanced cancer, but further therapeutic improvement is needed. We have previously shown that the zinc finger protein 36, C3H type-like 1 (ZFP36L1) en... Regulation of C/EBPbeta1 by Ras in mammary epithelial cells and the role of C/EBPbeta1 in oncogene-induced senescence [作者：Atwood, AA; Sealy, L,期刊：Oncogene, 页码：6004-6015 , 文章类型： Article，,卷期：2010年29-45] Overexpression of Ras(V12) in MCF10A cells, an immortalized mammary epithelial cell line, leads to transformation of these cells. We demonstrate that this is accompanied by degradation of C/EBPbeta1. C/EBP beta is a tran... Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells [作者：Olsen, BB; Issinger, OG; Guerra, B,期刊：Oncogene, 页码：6016-6026 , 文章类型： Article，,卷期：2010年29-45] The DNA-dependent protein kinase (DNA-PK) is a nuclear serine/threonine protein kinase composed of a large catalytic subunit (DNA-PKcs) and a heterodimeric DNA-targeting subunit Ku. DNA-PK is a major component of the non... C-terminal binding protein and poly(ADP)ribose polymerase 1 contribute to repression of the p21(waf1/cip1) promoter [作者：Madison, DL; Lundblad, JR,期刊：Oncogene, 页码：6027-6039 , 文章类型： Article，,卷期：2010年29-45] Transcriptional repression by the C-terminal binding protein (CtBP) is proposed to require nicotinamide adenine dinucleotide dehydrogenase (NAD(H). Previous studies have implicated CtBP in transcriptional repression of t... RhoA and RhoC are both required for the ROCK II-dependent promotion of centrosome duplication [作者：Kanai, M; Crowe, MS; Zheng, Y; Vande Woude, GF; Fukasawa, K,期刊：Oncogene, 页码：6040-6050 , 文章类型： Article，,卷期：2010年29-45] CDK2-cyclin E triggers centrosome duplication, and nucleophosmin (NPM/B23) is found to be one of its targets. NPM/B23 phosphorylated by CDK2-cyclin E acquires a high binding affinity to Rho-associated kinase (ROCK II), a... Low-dose paclitaxel synergizes with oncolytic adenoviruses via mitotic slippage and apoptosis in ovarian cancer [作者：Ingemarsdotter, CK; Baird, SK; Connell, CM; Oberg, D; Hallden, G; McNeish, IA,期刊：Oncogene, 页码：6051-6063 , 文章类型： Article，,卷期：2010年29-45] The microtubule-stabilizing drug paclitaxel has activity in relapsed ovarian cancer. dl922-947, an oncolytic adenovirus with a 24-bp deletion in E1A CR2, replicates selectively within and lyses cells with a dysregulated ... Interfering with RAS-effector protein interactions prevent RAS-dependent tumour initiation and causes stop-start control of cancer growth [作者：Tanaka, T; Rabbitts, TH,期刊：Oncogene, 页码：6064-6070 , 文章类型： Article，,卷期：2010年29-45] RAS mutations are the most common gain-of-function change in human cancer and promise to be a critical therapy target. As a new approach, we have used a surrogate to drug the 'undruggable' (that is, RAS-effector protein-... Biological reprogramming in acquired resistance to endocrine therapy of breast cancer [作者：Aguilar, H; Sole, X; Bonifaci, N; Serra-Musach, J; Islam, A; Lopez-Bigas, N; Mendez-Pertuz, M; Beijersbergen, RL; Lazaro, C; Urruticoechea, A; Pujana, MA,期刊：Oncogene, 页码：6071-6083 , 文章类型： Article，,卷期：2010年29-45] Endocrine therapies targeting the proliferative effect of 17 beta-estradiol through estrogen receptor alpha (ER alpha) are the most effective systemic treatment of ER alpha-positive breast cancer. However, most breast tu... MUC4 mucin-induced epithelial to mesenchymal transition: a novel mechanism for metastasis of human ovarian cancer cells (vol 29, pg 6084, 2010) [作者：Ponnusamy, MP; Lakshmanan, I; Jain, M; Das, S; Chakraborty, S; Dey, P; Batra, SK,期刊：Oncogene, 页码：6084-6084 , 文章类型： Correction，,卷期：2010年29-45] Serine/threonine phosphatases in the DNA damage response and cancer [作者：Peng, A; Maller, JL,期刊：Oncogene, 页码：5977-5988 , 文章类型： Review，,卷期：2010年29-45] The cellular response to DNA damage is a crucial surveillance mechanism that maintains genomic integrity and prevents cancer progression. Previous studies identified multiple Ser/Thr protein kinases that have pivotal rol...