- Novel, Broad Spectrum Anticancer Agents Containing the Tricyclic 5:7:5-Fused Diimidazodiazepine Ring System
[作者:KONDASKAR ATUL; KONDASKAR SHILPI; KUMAR RAJ; FISHBEIN JAMES C; MUVARAK NIDAL; LAPIDUS RENA G; SADOWSKA MARIOLA; EDELMAN MARTIN J; BOL GUUS M; VESUNA FARHAD; RAMAN VENU; HOSMANE RAMACHANDRA S,期刊:ACS Medicinal Chemistry Letters, 页码:252-256 , 文章类型: Article,,卷期:2011年2-3]
- Synthesis of a series of novel, broad spectrum anticancer agents containing the tricyclic 5:7:5-fused diimidazo[4,5-d:4',5'-f][1,3]diazepine ring system is reported. Compounds 1, 2, 8, 11, and 12 in the series show promi...
- Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes
[作者:ROMINE JEFFREY L; ST LAURENT DENIS R; LEET JOHN E; MARTIN SCOTT W; SERRANOWU MICHAEL H; YANG FUKANG; GAO MIN; OBOYLE DONALD R II; LEMM JULIE A; SUN JINHUA; NOWER PETER T; HUANG XIAOHUA STELLA; DESHPANDE MILIND S; MEANWELL NICHOLAS A; SNYDER LAWRENCE B,期刊:ACS Medicinal Chemistry Letters, 页码:224-229 , 文章类型: Article,,卷期:2011年2-3]
- The iminothiazolidinone BMS-858 (2) was identified as a specific inhibitor of HCV replication in a genotype 1b replicon assay via a high-throughput screening campaign. A more potent analogue, BMS-824 (18), was used in re...
- Discovery of a Potent and Short-Acting Oral Calcilytic with a Pulsatile Secretion of Parathyroid Hormone
[作者:SHINAGAWA YUKO; INOUE TERUHIKO; KATSUSHIMA TAKEO; KIGUCHI TOSHIHIRO; IKENOGAMI TAKU; OGAWA NAOKI; FUKUDA KENJI; HIRATA KAZUYUKI; HARADA KAZUHITO; TAKAGI MASAKI; NAKAGAWA TAKASHI; KIMURA SHUICHI; MATSUO YUSHI; MAEKAWA MARIKO; HAYASHI MILDO; SOEJIMA YUKI; TAKAHASHI MITSURU; SHINDO MASANORI; HASHIMOTO HIROMASA,期刊:ACS Medicinal Chemistry Letters, 页码:238-242 , 文章类型: Article,,卷期:2011年2-3]
- Short-acting oral calcilytics, calcium-sensing receptor (CaSR) antagonists, have been considered as alternatives for parathyroid hormone (PTH), an injectable bone anabolic drug used in the treatment of osteoporosis. Prev...
- In Vitro and In Vivo Osteogenic Activity of Largazole
[作者:LEE SUUI; KWAK HAN BOK; PI SUNGHEE; YOU HYUNGKEUN; BYEON SEONG RIM; YING YONGCHENG; LUESCH HENDRIK; HONG JIYONG; KIM SEONG HWAN,期刊:ACS Medicinal Chemistry Letters, 页码:248-251 , 文章类型: Article,,卷期:2011年2-3]
- Due to their capability of modifying chromatin structure and thereby regulating gene transcription, histone deacetylases (HDACs) have been reported to play important roles in osteogenesis and considered a promising poten...
- Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A(2B) Adenosine Receptor Antagonist
[作者:EASTWOOD PAUL; ESTEVE CRISTINA; GONZALEZ JACOB; FONQUERNA SILVIA; AIGUADE JOSEP; CARRANCO INES; DOMENECH TERESA; APARICI MONICA; MIRALPEIX MONTSERRAT; ALBERTI JOAN; CORDOBA MONICA; FERNANDEZ RAQUEL; PONT MERCE; GODESSART NURIA; PRATS NEUS; ISABEL LOZA MARIA; ISABEL CADAVID MARIA; NUEDA ARSENIO; VIDAL BERNAT,期刊:ACS Medicinal Chemistry Letters, 页码:213-218 , 文章类型: Article,,卷期:2011年2-3]
- The structure activity relationships for a series of pyrazine-based A(2B) adenosine receptor antagonists are described. From this work, LAS101057 (17), a potent, selective, and orally efficacious A(2B) receptor antagonis...
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