- Synthesis and characterization of reactive poloxamer 407s for biomedical applications
[作者:Niu, GG; Du, FY; Song, L; Zhang, HB; Yang, J; Cao, H; Zheng, YD; Yang, Z; Wang, GJ; Yang, H; Zhu, SQ,期刊:Journal of controlled release, 页码:49-56 , 文章类型: Article,,卷期:2009年138-1]
- The drawbacks of poloxamer hydrogel, such as dissolving quickly in aqueous solution, have limited its biomedical application. In order to improve the stability of hydrogel, a novel system was developed by combining the r...
- Preparation and characterization of protein loaded microspheres based on a hydroxylated aliphatic polyester, poly (lactic-co-hydroxymethyl glycolic acid)
[作者:Ghassemi, AH; van Steenbergen, MJ; Talsma, H; van Nostrum, CF; Jiskoot, W; Crommelin, DJA; Hennink, WE,期刊:Journal of controlled release, 页码:57-63 , 文章类型: Article,,卷期:2009年138-1]
- The purpose of this study was to investigate the suitability of a novel hydroxylated aliphatic polyester, poly (lactic-co-hydroxymethyl glycolic acid) (PLHMGA), as controlled release system for pharmaceutical proteins. D...
- Lysine-based peptide-functionalized PLGA foams for controlled DNA delivery
[作者:Nie, HM; Khew, ST; Lee, LY; Poh, KL; Tong, YW; Wang, CH,期刊:Journal of controlled release, 页码:64-70 , 文章类型: Article,,卷期:2009年138-1]
- Due to its hydrophobicity and negatively charged surfaces, PLGA-based scaffolds have encountered problems in controlled-release and tissue engineering applications. The effects of charge modification of PLGA micro-porous...
- Parameters affecting organization and transfection efficiency of amphiphilic copolymers/DNA carriers
[作者:Roques, C; Bouchemal, K; Ponchel, G; Fromes, Y; Fattal, E,期刊:Journal of controlled release, 页码:71-77 , 文章类型: Article,,卷期:2009年138-1]
- Amphiphilic block copolymers are attracting increasing interest in the Held of gene therapy, especially for transfection of striated muscles. However, little is known about the parameters affecting their transfection eff...
- Transepithelial transport of PEGylated anionic poly(amidoamine) dendrimers: Implications for oral drug delivery
[作者:Sweet, DM; Kolhatkar, RB; Ray, A; Swaan, P; Ghandehari, H,期刊:Journal of controlled release, 页码:78-85 , 文章类型: Article,,卷期:2009年138-1]
- The purpose of this work was to assess the impact of PEGylation on transepithelial transport of anionic poly (amidoamine) dendrimers. Cytotoxicity, uptake and transport across Caco-2 cells of PEGylated G3.5 and G4.5 PAMA...
- Drug delivery systems in HIV pharmacotherapy: What has been done and the challenges standing ahead
[作者:Sosnik, A; Chiappetta, DA; Carcaboso, AM,期刊:Journal of controlled release, 页码:2-15 , 文章类型: Review,,卷期:2009年138-1]
- Worldwide, over 40 million people are infected with the Human immunodeficiency Virus (HIV). The High Activity Antiretroviral Therapy (HAART) combines at least three antiretroviral (ARV) drugs and, for over a decade, has ...
- In vitro and in vivo characterization on amorphous solid dispersion of cyclosporine A for inhalation therapy
[作者:Onoue, S; Sato, H; Kawabata, Y; Mizumoto, T; Hashimoto, N; Yamada, S,期刊:Journal of controlled release, 页码:16-23 , 文章类型: Article,,卷期:2009年138-1]
- Cyclosporine A (CsA) has been clinically used as immunosuppressant, and new application for airway inflammation was also proposed. However, the clinical use of CsA was limited due to severe adverse effects after systemic...
- An efficient ternary complex of acetazolamide with HP-beta-CD and TEA for topical ocular administration
[作者:Palma, SD; Tartara, LI; Quinteros, D; Allemandi, DA; Longhi, MR; Granero, GE,期刊:Journal of controlled release, 页码:24-31 , 文章类型: Article,,卷期:2009年138-1]
- In order to enhance the ocular bioavailability of acetazolamide (ACZ), a multicomponent complex with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and triethanolamine (TEA) was prepared to be applied topically. In vitro c...
- Studying the effectiveness of penetration enhancers to deliver retinol through the stratum cornum by in vivo confocal Raman spectroscopy
[作者:Melot, M; Pudney, PDA; Williamson, AM; Caspers, PJ; Van Der Pol, A; Puppels, GJ,期刊:Journal of controlled release, 页码:32-39 , 文章类型: Article,,卷期:2009年138-1]
- The purpose of this study is to monitor in vivo the effect of chemical penetration enhancers on the delivery of trans-retinol into human skin. Chemical penetration enhancers reversibly alter barrier properties of the SC ...
- Quantitative XPS depth profiling of codeine loaded poly(L-lactic acid) films using a coronene ion sputter source
[作者:Rafati, A; Davies, MC; Shard, AG; Hutton, S; Mishra, G; Alexander, MR,期刊:Journal of controlled release, 页码:40-44 , 文章类型: Article,,卷期:2009年138-1]
- The controlled release of active pharmaceutical ingredients from polymers over prolonged periods of time is vital for the function of drug eluting stents and other drug loaded delivery devices. Characterisation of the dr...
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