- The Antimalarial Ferroquine: Role of the Metal and Intramolecular Hydrogen Bond in Activity and Resistance
[作者:DUBAR FAUSTINE; EGAN TIMOTHY J; PRADINES BRUNO; KUTER DAVID; NCOKAZI KANYILE K; FORGE DELPHINE; PAUL JEANFRANCOIS; PIERROT CHRISTINE; KALAMOU HADIDJATOU; KHALIFE JAMAL; BUISINE ERIC; ROGIER CHRISTOPHE; VEZIN HERVE; FORFAR ISABELLE; SLOMIANNY CHRISTIAN; TRIVELLI XAVIER; KAPISHNIKOV SERGEY; LEISEROWITZ LESLIE; DIVE DANIEL; BIOT CHRISTOPHE,期刊:ACS CHEMICAL BIOLOGY, 页码:275-287 , 文章类型: Article,,卷期:2011年6-3]
- Inhibition of hemozoin biocrystallization is considered the main mechanism of, action of 4-aminoquinoline antimalarials including chloroquine (CQ) but cannot,fully explain the activity of ferroquine (FQ) which has been r...
- Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases
[作者:COMESS KENNETH M; SUN CHAOHONG; ABADZAPATERO CELE; GOEDKEN ERIC R; GUM REBECCA J; BORHANI DAVID W; ARGIRIADI MARIA; GROEBE DUNCAN R; JIA YONG; CLAMPIT JILL E; HAASCH DEANNA L; SMITH HARRIET T; WANG SANYI; SONG DANYING; COEN MICHAEL L; CLOUTIER TIMOTHY E; TANG HUA; CHENG XUEHENG; QUINN CHRISTOPHER; LIU BO; XIN ZHILI; LIU GANG; FRY ELIZABETH H; STOLL VINCENT; NG TERESA I; BANACH DAVID; MARCOTTE DOUG; BURNS DAVID J; CALDERWOOD DAVID J; HAJDUK PHILIP J,期刊:ACS CHEMICAL BIOLOGY, 页码:234-244 , 文章类型: Article,,卷期:2011年6-3]
- Inhibition of protein kinases has validated therapeutic utility for cancer, with at least seven kinase inhibitor drugs on the market Protein-kinase inhibition also has significant potential for a variety of other disease...
- Identification of SR3335 (ML-176): A Synthetic ROR alpha Selective Inverse Agonist
[作者:KUMAR NARESH; KOJETIN DOUGLAS J; SOLT LAURA A; KUMAR K GANESH; NUHANT PHILIPPE; DUCKETT DEREK R; CAMERON MICHAEL D; BUTLER ANDREW A; ROUSH WILLIAM R; GRIFFIN PATRICK R; BURRIS THOMAS P,期刊:ACS CHEMICAL BIOLOGY, 页码:218-222 , 文章类型: Article,,卷期:2011年6-3]
- Several nuclear receptors (NRs) are still characterized as orphan.. receptors because ligands have not yet been identified for these proteins:: The retinoic acid receptor related receptors (RORs) have no well-defined phy...
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