- The Metastasis-Associated Anterior Gradient 2 Protein Is Correlated with Poor Survival of Breast Cancer Patients
[作者:Barraclough, DL; Platt-Higgins, A; Rudland, SD; Barraclough, R; Winstanley, J; West, CR; Rudland, PS,期刊:American Journal of Pathology, 页码:1848-1857 , 文章类型: Article,,卷期:2009年175-5]
- The secreted metastasis-inducing protein, human anterior gradient 2 (AGR2), has been independently reported to be associated with either a reduced or an increased survival of different groups of patients with breast canc...
- Matrix Metalloproteinase-3 Accelerates Wound Healing following Dental Pulp Injury
[作者:Zheng, L; Amano, K; Iohara, K; Ito, M; Imabayashi, K; Into, T; Matsushita, K; Nakamura, H; Nakashima, M,期刊:American Journal of Pathology, 页码:1905-1914 , 文章类型: Article,,卷期:2009年175-5]
- Matrix metalloproteinases (MMPs) are implicated in a wide range of physiological and pathological processes, including morphogenesis, wound heating, angiogenesis, inflammation, and cancer. Angiogenesis is essential for r...
- The Cellular Biology of Flexor Tendon Adhesion Formation An Old Problem in a New Paradigm
[作者:Wong, JKF; Lui, YH; Kapacee, Z; Kadler, KE; Ferguson, MWJ; McGrouther, DA,期刊:American Journal of Pathology, 页码:1938-1951 , 文章类型: Article,,卷期:2009年175-5]
- Intrasynovial flexor tendon injuries of the hand can frequently be complicated by tendon adhesions to the surrounding sheath, limiting finger function. We have developed a new tendon injury model in the mouse to investig...
- Contribution of Macrophages to Angiogenesis Induced by Vascular Endothelial Growth Factor Receptor-3-Specific Ligands
[作者:Chung, ES; Chauhan, SK; Jin, YP; Nakao, S; Hafezi-Moghadam, A; van Rooijen, N; Zhang, Q; Chen, L; Dana, R,期刊:American Journal of Pathology, 页码:1984-1992 , 文章类型: Article,,卷期:2009年175-5]
- Vascular endothelial growth factor receptor (VEGFR)-2 is a major stimulator of hemangiogenesis (HA), whereas VEGFR-3 stimulates lymphangiogenesis (LA). Contrary to this understanding, we demonstrate that implantation of ...
- Transient Activation of Wnt/beta-Catenin Signaling Induces Abnormal Growth Plate Closure and Articular Cartilage Thickening in Postnatal Mice
[作者:Yuasa, T; Kondo, N; Yasuhara, R; Shimono, K; Mackeem, S; Pacifici, M; Iwamoto, M; Enomoto-Iwamoto, M,期刊:American Journal of Pathology, 页码:1993-2003 , 文章类型: Article,,卷期:2009年175-5]
- Wnt/beta-catenin signaling is required for skeletal development and organization and for function of the growth plate and articular cartilage. To further clarify these roles and their possible pathophysiological importan...
- Thymic Indoleamine 2,3-Dioxygenase-Positive Eosinophils in Young Children Potential Role In Maturation of the Naive Immune System
[作者:Tulic, MK; Sly, PD; Andrews, D; Crook, M; Davoine, F; Odemuyiwa, SO; Charles, A; Hodder, ML; Prescott, SL; Holt, PG; Moqbel, R,期刊:American Journal of Pathology, 页码:2043-2052 , 文章类型: Article,,卷期:2009年175-5]
- Eosinophils expressing indoleamine 2, 3-dioxygenase (IDO) may contribute to T-helper cell (Th)2 predominance. To characterize human thymus IDO+ eosinophil ontogeny relative to Th2 regulatory gene expression, we processed...
- Latent Cytomegalovirus Infection Exacerbates Experimental Colitis
[作者:Onyeagocha, C; Hossain, MS; Kumar, A; Jones, RM; Roback, J; Gewirtz, AT,期刊:American Journal of Pathology, 页码:2034-2042 , 文章类型: Article,,卷期:2009年175-5]
- inflammatory bowel disease (IBD) severity is positively correlated with cytomegalovirus (CMV) infection. This may reflect CMV triggering and/or exacerbating flares of IBD and/or IBD or immunosuppressive drugs administere...
- Glycosaminoglycan-Mediated Loss of Cathepsin K Collagenolytic Activity in MPS I Contributes to Osteoclast and Growth Plate Abnormalities
[作者:Wilson, S; Hashamiyan, S; Clarke, L; Saftig, P; Mort, J; Dejica, VM; Bromme, D,期刊:American Journal of Pathology, 页码:2053-2062 , 文章类型: Article,,卷期:2009年175-5]
- Mucopolysaccharidoses are a group of lysosomal storage diseases characterized by the build-up of glycosaminoglycans (GAGs) and severe skeletal abnormalities. As GAGs can regulate the collagenolytic activity of the major ...
- Dysregulation of Insulin Signaling, Glucose Transporters, O-GlcNAcylation, and Phosphorylation of Tau and Neurofilaments in the Brain Implication for Alzheimer's Disease
[作者:Deng, YQ; Li, B; Lu, Y; Iqbal, K; Grundke-Iqbal, I; Gong, CX,期刊:American Journal of Pathology, 页码:2089-2098 , 文章类型: Article,,卷期:2009年175-5]
- Recent studies have suggested a possible role of insulin dysfunction in the pathogenesis of sporadic Alzheimer's disease (AD). in AD, brain glucose metabolism is impaired, and this impairment appears to precede the patho...
- Amyloid-Peptide Vaccinations Reduce beta-Amyloid Plaques but Exacerbate Vascular Deposition and Inflammation in the Retina of Alzheimer's Transgenic Mice
[作者:Liu, BQ; Rasool, S; Yang, ZK; Glabe, CG; Schreiber, SS; Ge, J; Tan, ZQ,期刊:American Journal of Pathology, 页码:2099-2110 , 文章类型: Article,,卷期:2009年175-5]
- Alzheimer's disease (AD) is pathologically characterized by accumulation of beta-amyloid (A beta) protein deposits and/or neurofibriffary tangles in association with progressive cognitive deficits. Although numerous stud...
- Microglia Activated with the Toll-Like Receptor 9 Ligand CpG Attenuate Oligomeric Amyloid beta Neurotoxicity in in Vitro and in Vivo Models of Alzheimer's Disease
[作者:Doi, Y; Mizuno, T; Maki, Y; Jin, S; Mizoguchi, H; Ikeyama, M; Doi, M; Michikawa, M; Takeuchi, H; Suzumura, A,期刊:American Journal of Pathology, 页码:2121-2132 , 文章类型: Article,,卷期:2009年175-5]
- Soluble oligomeric amyloid beta (oA beta) 1-42 causes synaptic dysfunction and neuronal injury in Alzheimer's disease (AD). Although accumulation of microglia around senile plaques is a hallmark of AD pathology, the role...
- Unilateral Blood Flow Decrease Induces Bilateral and Symmetric Responses in the Immature Brain
[作者:Villapol, S; Bonnin, P; Fau, S; Baud, O; Renolleau, S; Charriaut-Marlangue, C,期刊:American Journal of Pathology, 页码:2111-2120 , 文章类型: Article,,卷期:2009年175-5]
- The effects of hemodynamic changes in the developing brain have yet to be fully understood. The aim of this study was to explore the relationship between perturbations of the cerebral blood flow in the developing brain v...
- Cripto-1 Is Required for Hypoxia to Induce Cardiac Differentiation of Mouse Embryonic Stem Cells
[作者:Bianco, C; Cotten, C; Lonardo, E; Strizzi, L; Baraty, C; Mancino, M; Gonzales, M; Watanabe, K; Nagaoka, T; Berry, C; Arai, AE; Minchiotti, G; Salomon, DS,期刊:American Journal of Pathology, 页码:2146-2158 , 文章类型: Article,,卷期:2009年175-5]
- Cripto-1 is a membrane-bound protein that is highly expressed in embryonic stem cells and in human tumors. in the present study, we investigated the effect of low levels of oxygen, which occurs naturally in rapidly growi...
- Contrasting Actions of Selective Inhibitors of Angiopoietin-1 and Angiopoietin-2 on the Normalization of Tumor Blood Vessels
[作者:Falcon, BL; Hashizume, H; Koumoutsakos, P; Chou, JL; Bready, JV; Coxon, A; Oliner, JD; McDonald, DM,期刊:American Journal of Pathology, 页码:2159-2170 , 文章类型: Article,,卷期:2009年175-5]
- Angiopoictin-1 (Ang1) and angiopoietin-2 (Ang2) have complex actions in angiogenesis and vascular remodeling due to their effects on Tie2 receptor signaling. Ang2 blocks Ang1-mediated activation of Tie2 in endothelial ce...
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