- Amplification of the Urokinase-Type Plasminogen Activator Receptor (uPAR) Gene in Ductal Pancreatic Carcinomas Identifies a Clinically High-Risk Group
[作者:Hildenbrand, R; Niedergethmann, M; Marx, A; Belharazem, D; Allgayer, H; Schleger, C; Strobel, P,期刊:American Journal of Pathology, 页码:2246-2253 , 文章类型: Article,,卷期:2009年174-6]
- The serine protease urokinase-type plasminogen activator (uPA) and its receptor (uPAR) are known to be involved in the invasion and metastasis of many solid tumors. In this study, we analyzed the role of the uPAR/uPA sys...
- Platelet-Derived Hyaluronidase 2 Cleaves Hyaluronan into Fragments that Trigger Monocyte-Mediated Production of Proinflammatory Cytokines
[作者:de la Motte, C; Nigro, J; Vasanji, A; Rho, H; Kessler, S; Bandyopadhyay, S; Danese, S; Fiocchi, C; Stern, R,期刊:American Journal of Pathology, 页码:2254-2264 , 文章类型: Article,,卷期:2009年174-6]
- Hyaluronan (RA) occurs in the body as a large, hydrating, space-filling, carbohydrate polymer in the extracellular matrix; it has both anti-angiogenic and immunosuppressive properties. Cleavage of HA results in the gener...
- Molecular Identification of "Latent Precancers" for Endometrial Serous Carcinoma in Benign-Appearing Endometrium
[作者:Zhang, X; Liang, SX; Jia, L; Chen, N; Fadare, O; Schwartz, PE; Kong, BH; Zheng, WX,期刊:American Journal of Pathology, 页码:2000-2006 , 文章类型: Article,,卷期:2009年174-6]
- Alteration of p53 is an early event in the development of endometrial serous carcinoma (ESC). We have recently identified a group of benign-looking endometria with p53 overexpression, designated "p53 signatures." In this...
- Atherosclerosis in LDLR-Knockout Mice Is Inhibited, but Not Reversed, by the PPAR gamma Ligand Pioglitazone
[作者:Nakaya, H; Summers, BD; Nicholson, AC; Gotto, AM; Hajjar, DP; Han, JH,期刊:American Journal of Pathology, 页码:2007-2014 , 文章类型: Article,,卷期:2009年174-6]
- Thiazolidinediones, a class of drugs for the treatment of type-2 diabetes, are synthetic ligands for peroxisome proliferator-activated receptor-gamma. They have been demonstrated to possess cardioprotective effects in hu...
- Expression of a Soluble Isoform of Cell Adhesion Molecule 1 in the Brain and Its Involvement in Directional Neurite Outgrowth
[作者:Hagiyama, M; Ichiyanagi, N; Kimura, KB; Muralkami, Y; Ito, A,期刊:American Journal of Pathology, 页码:2278-2289 , 文章类型: Article,,卷期:2009年174-6]
- Cell adhesion molecule I (CADM1), an immunoglobulin superfamily member, is expressed on superior cervical ganglion neurites and mediates cell-cell adhesion by trans-homophilic binding. in addition to the membrane-bound f...
- Accelerated Course of Experimental Autoimmune Encephalomyelitis in PD-1-Deficient Central Nervous System Myelin Mutants
[作者:Kroner, A; Schwab, N; Ip, CW; Ortler, S; Gobel, K; Nave, KA; Maurer, M; Martini, R; Wiendl, H,期刊:American Journal of Pathology, 页码:2290-2299 , 文章类型: Article,,卷期:2009年174-6]
- It is assumed that the onset and course of autoimmune inflammatory central nervous system (CNS) disorders (eg, multiple sclerosis) are influenced by factors that afflict immune regulation as well as CNS vulnerability. We...
- An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers
[作者:Witkiewicz, AK; Dasgupta, A; Sotgia, F; Mercier, I; Pestell, RG; Sabel, M; Kleer, CG; Brody, JR; Lisanti, MP,期刊:American Journal of Pathology, 页码:2023-2034 , 文章类型: Article,,卷期:2009年174-6]
- Previously, we showed that caveolin-1 (Cav-1) expression is down-regulated in human breast cancer-associated fibroblasts. However, it remains unknown whether loss of Cav-1 occurs in the breast tumor stroma in vivo. Here,...
- Stromal Cell Expression of Caveolin-1 Predicts Outcome in Breast Cancer
[作者:Sloan, EK; Ciocca, DR; Pouliot, N; Natoli, A; Restall, C; Henderson, MA; Fanelli, MA; Cuello-Carrion, FD; Gago, FE; Anderson, RL,期刊:American Journal of Pathology, 页码:2035-2043 , 文章类型: Article,,卷期:2009年174-6]
- Caveolin-1 has been linked to tumor progression and clinical outcome in breast cancer, but a clear resolution of its role as a prognostic marker is lacking. We assessed caveolin-1 levels in normal breast tissue and two b...
- Protection of Hippocampal Neurogenesis from Toll-Like Receptor 4-Dependent Innate Immune Activation by Ablation of Prostaglandin E-2 Receptor Subtype EP1 or EP2
[作者:Keene, CD; Chang, R; Stephen, C; Nivison, M; Nutt, SE; Look, A; Breyer, RM; Horner, PJ; Hevner, R; Montine, TJ,期刊:American Journal of Pathology, 页码:2300-2309 , 文章类型: Article,,卷期:2009年174-6]
- Prostaglandin E-2 is one of several eicosanoid products of the cyclooxygenase isozymes and is a key regulator of innate immune responses; it also possesses paracrine effects on mature neurons. The prostaglandin E, recept...
- Cooperative Phagocytes Resident Microglia and Bone Marrow Immigrants Remove Dead Photoreceptors in Retinal Lesions
[作者:Joly, S; Francke, M; Ulbricht, E; Beck, S; Seeliger, M; Hirrlinger, P; Hirrlinger, J; Lang, KS; Zinkernage, M; Odernatt, B; Samardzija, M; Reichenbach, A; Grimm, C; Reme, CE,期刊:American Journal of Pathology, 页码:2310-2323 , 文章类型: Article,,卷期:2009年174-6]
- Phagocytosis is essential for the removal of photoreceptor debris following retinal injury. We used two mouse models, mice injected with green fluorescent protein-labeled bone marrow cells or green fluorescent protein-la...
- Staphylococcal Nuclease Domain-Containing Protein 1 as a Potential Tissue Marker for Prostate Cancer
[作者:Kuruma, H; Kamata, Y; Takahashi, H; Igarashi, K; Kimura, T; Miki, K; Miki, J; Sasaki, H; Hayashi, N; Egawa, S,期刊:American Journal of Pathology, 页码:2044-2050 , 文章类型: Article,,卷期:2009年174-6]
- Using high molecular-weight proteomic analysis, we previously showed that Staphylococcal nuclease domain-containing protein 1 (SND1) is highly expressed in recurrent androgen-insensitive prostate cancer tissues. SND1 is ...
- A Reduction in Pten Tumor Suppressor Activity Promotes ErbB-2-Induced Mouse Prostate Adenocarcinoma Formation through the Activation of Signaling Cascades Downstream of PDK1
[作者:Rodriguez, OC; Lai, EW; Vissapragada, S; Cromelin, C; Avetian, M; Salinas, P; Ramos, H; Kallakury, B; Casimiro, M; Lisanti, MP; Tanowitz, HB; Pacak, K; Glazer, RI; Avantaggiati, M; Albanese, C,期刊:American Journal of Pathology, 页码:2051-2060 , 文章类型: Article,,卷期:2009年174-6]
- Loss of function at the Pten tumor-suppressor locus is a common genetic modification found in human prostate cancer. While recent in vivo and in vitro data support an important role of aberrant ErbB-2 signaling to clinic...
- CXCL16 Is Expressed in Podocytes and Acts as a Scavenger Receptor for Oxidized Low-Density Lipoprotein
[作者:Gutwein, P; Abdel-Bakky, MS; Schramme, A; Doberstein, K; Kampfer-Kolb, N; Amann, K; Hauser, IA; Obermueller, N; Bartel, C; Abdel-Aziz, AAH; El Sayed, ESM; Pfeilschifter, J,期刊:American Journal of Pathology, 页码:2061-2072 , 文章类型: Article,,卷期:2009年174-6]
- Podocytes are a crucial cell type in the kidney and play an important role in the pathology of glomerular kidney diseases like membranous nephropathy (MN). The identification of new factors involved in the progression of...
- SV40-Induced Expression of Calretinin Protects Mesothelial Cells from Asbestos Cytotoxicity and May Be a Key Factor Contributing to Mesothelioma Pathogenesis
[作者:Henzi, T; Blum, WV; Pfefferli, M; Kawecki, TJ; Salicio, V; Schwaller, B,期刊:American Journal of Pathology, 页码:2324-2336 , 文章类型: Article,,卷期:2009年174-6]
- The calcium-binding protein calretinin has emerged as a useful marker for the identification of mesotheliomas of the epithelioid and mixed types, but its putative role in tumor development has not been addressed previous...
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