- Luminal Cathepsin G and Protease-Activated Receptor 4 A Duet Involved in Alterations of the Colonic Epithelial Barrier in Ulcerative Colitis
[作者:Dabek, M; Ferrier, L; Roka, R; Gecse, K; Annahazi, A; Moreau, J; Escourrou, J; Cartier, C; Chaumaz, G; Leveque, M; Ait-Belgnaoui, A; Wittmann, T; Theodorou, V; Bueno, L,期刊:American Journal of Pathology, 页码:207-214 , 文章类型: Article,,卷期:2009年175-1]
- Impairment of the colonic epithelial barrier and neutrophil infiltration are common features of inflammatory bowel disease. Luminal proteases affect colonic permeability through protease-activated receptors (PARs). We ev...
- Disrupted Cell Cycle Control in Cultured Endometrial Cells from Patients with Endometriosis Harboring the Progesterone Receptor Polymorphism PROGINS
[作者:D'Amora, P; Maciel, TT; Tambellini, R; Mori, MA; Pesquero, JB; Sato, H; Girao, MJBC; da Silva, IDCG; Schor, E,期刊:American Journal of Pathology, 页码:215-224 , 文章类型: Article,,卷期:2009年175-1]
- Presently, little is understood about how endometriosis is established or maintained, or how genetic factors can predispose women to the disease. Because of the crucial role that the progesterone receptor polymorphism PR...
- Reactive Oxygen Species Controls Endometriosis Progression
[作者:Ngo, C; Chereau, C; Nicco, C; Weill, B; Chapron, C; Batteux, F,期刊:American Journal of Pathology, 页码:225-234 , 文章类型: Article,,卷期:2009年175-1]
- Endometriosis is associated with chronic inflammation, and reactive oxygen species (ROS) are proinflammatory mediators that modulate cell proliferation. We have investigated whether the dysregulation of ROS production in...
- Decreased Catalase Expression and Increased Susceptibility to Oxidative Stress in Primary Cultured Corneal Fibroblasts from Patients with Granular Corneal Dystrophy Type II
[作者:Choi, SI; Kim, TI; Kim, KS; Kim, BY; Ahn, SY; Cho, HJ; Lee, HK; Cho, HS; Kim, EK,期刊:American Journal of Pathology, 页码:248-261 , 文章类型: Article,,卷期:2009年175-1]
- Granular corneal dystrophy type II (GCD II) is an autosomal dominant disorder characterized by age-dependent progressive accumulation of transforming growth factor-beta-induced protein (TGFBIp) deposits in the corneal st...
- Endothelin-Converting Enzyme-2 Is Increased in Alzheimer's Disease and Up-Regulated by A beta
[作者:Palmer, JC; Baig, S; Kehoe, PG; Love, S,期刊:American Journal of Pathology, 页码:262-270 , 文章类型: Article,,卷期:2009年175-1]
- Alzheimer's disease (AD) is thought to be caused by the accumulation of amyloid beta (A beta) peptide within the brain. Endothelin-converting enzyme-2 (ECE-2), which is expressed in neural tissues, cleaves 'big endotheli...
- Independent Effects of Intra- and Extracellular A beta on Learning-Related Gene Expression
[作者:Wegenast-Braun, BM; Maisch, AF; Eicke, D; Radde, R; Herzig, MC; Staufenbiel, M; Jucker, M; Calhoun, ME,期刊:American Journal of Pathology, 页码:271-282 , 文章类型: Article,,卷期:2009年175-1]
- Alzheimer's disease is characterized by numerous pathological abnormalities, including amyloid beta (A beta) deposition in the brain parenchyma and vasculature. In addition, intracellular A beta accumulation may affect n...
- Up-Regulation of Soluble Axl and Mer Receptor Tyrosine Kinases Negatively Correlates with Gas6 in Established Multiple Sclerosis Lesions
[作者:Weinger, JG; Omari, KM; Marsden, K; Raine, CS; Shafit-Zagardo, B,期刊:American Journal of Pathology, 页码:283-293 , 文章类型: Article,,卷期:2009年175-1]
- Multiple sclerosis is a disease that is characterized by inflammation, demyelination, and axonal damage; it ultimately forms gliotic scars and lesions that severely compromise the function of the central nervous system. ...
- Involvement of WAVE Accumulation in A beta/APP Pathology-Dependent Tangle Modification in Alzheimer's Disease
[作者:Takata, K; Kitamura, Y; Nakata, Y; Matsuoka, Y; Tomimoto, H; Taniguchi, T; Shimohama, S,期刊:American Journal of Pathology, 页码:17-24 , 文章类型: Article,,卷期:2009年175-1]
- Synaptic deficits are closely correlated with cognitive dysfunction in Alzheimer's disease (AD), and synaptic integrity is regulated by the actin cytoskeleton. We demonstrated here that the Wiskott-Aldrich syndrome prote...
- Development of a Malignancy-Associated Proteomic Signature for Diffuse Large B-Cell Lymphoma
[作者:Romesser, PB; Perlman, DH; Faller, DV; Costello, CE; McComb, ME; Denis, GV,期刊:American Journal of Pathology, 页码:25-35 , 文章类型: Article,,卷期:2009年175-1]
- The extreme pathological diversity of non-Hodgkin's lymphomas has made their accurate histological assessment difficult. New diagnostics and treatment modalities are urgently needed for these lymphomas, particularly in d...
- In Situ Analysis of Protein S-Glutathionylation in Lung Tissue Using Glutaredoxin-1-Catalyzed Cysteine Derivatization
[作者:Aesif, SW; Anathy, V; Havermans, M; Guala, AS; Ckless, K; Taatjes, DJ; Janssen-Heininger, YMW,期刊:American Journal of Pathology, 页码:36-45 , 文章类型: Article,,卷期:2009年175-1]
- Protein S-glutathionylation (PSSG) is a posttranslational modification that involves the conjugation of the small antioxidant molecule glutathione to cysteine residues and is emerging as a critical mechanism of redox-bas...
- Novel Serum Markers of Fibrosis Progression for the Follow-Up of Hepatitis C Virus-infected Patients
[作者:Caillot, F; Hiron, M; Goria, O; Gueudin, M; Francois, A; Scotte, M; Daveau, M; Salier, JP,期刊:American Journal of Pathology, 页码:46-53 , 文章类型: Article,,卷期:2009年175-1]
- Liver biopsy is considered the gold-standard method for the assessment of liver fibrosis during follow-up of hepatitis C virus-infected patients, but this invasive procedure is not devoid of complications. The aim of the...
- Paradoxical Effects of PDGF-BB Overexpression in Endothelial Cells on Engineered Blood Vessels In Vivo
[作者:Au, P; Tam, J; Duda, DG; Lin, PC; Munn, LL; Fukumura, D; Jain, RK,期刊:American Journal of Pathology, 页码:294-302 , 文章类型: Article,,卷期:2009年175-1]
- Therapeutic revascularization with either exogenous angiogenic growth factors or vascular cells has yet to demonstrate efficacy in the clinic. Injection of angiogenic growth factors often produces unstable and abnormal b...
- Human Umbilical Cord Mesenchymal Stem Cells Reduce Fibrosis of Bleomycin-Induced Lung Injury
[作者:Moodley, Y; Atienza, D; Manuelpillai, U; Samuel, CS; Tchongue, J; Ilancheran, S; Boyd, R; Trounson, A,期刊:American Journal of Pathology, 页码:303-313 , 文章类型: Article,,卷期:2009年175-1]
- Acute respiratory distress syndrome is characterized by loss of lung tissue as a result of inflammation and fibrosis. Augmenting tissue repair by the use of mesenchymal stem cells may be an important advance in treating ...
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