- The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers
[作者：Zudaire, E; Cuesta, N; Murty, V; Woodson, K; Adarns, L; Gonzalez, N; Martinez, A; Narayan, G; Kirsch, I; Franklin, W; Hirsch, F; Birrer, M; Cuttittal, F,期刊：Journal of clinical investigation, 页码：640-650 , 文章类型： Article，,卷期：2008年118-2]
- The aryl hydrocarbon receptor repressor (AHRR) is a bHLH/Per-ARNT-Sim transcription factor located in a region of chromosome 5 (5p15.3) that has been proposed to contain one or more tumor suppressor genes. We report here...
- Eya4-deficient mice are a model for heritable otitis media
[作者：Depreux, FFS; Darrow, K; Conner, DA; Eavey, RD; Liberman, MC; Seidman, CE; Seidman, JG,期刊：Journal of clinical investigation, 页码：651-658 , 文章类型： Article，,卷期：2008年118-2]
- Otitis media is an extremely common pediatric inflammation of the middle ear that often causes pain and diminishes hearing. Vulnerability to otitis media is due to eustachian tube dysfunction as well as other poorly unde...
- SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model
[作者：Harraz, MM; Marden, JJ; Zhou, WH; Zhang, Y; Williams, A; Sharov, VS; Nelson, K; Luo, M; Paulson, H; Schoneich, C; Engelhardt, JF,期刊：Journal of clinical investigation, 页码：659-670 , 文章类型： Article，,卷期：2008年118-2]
- Neurodegeneration in familial amyotrophic lateral sclerosis (ALS) is associated with enhanced redox stress caused by dominant mutations in superoxide dismutase-1 (SOD1). SOD1 is a cytosolic enzyme that facilitates the co...
- Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
[作者：Wahrle, SE; Jiang, H; Parsadanian, M; Kim, J; Li, AM; Knoten, A; Jain, S; Hirsch-Reinshagen, V; Wellington, CL; Bales, KR; Paul, SM; Holtzman, DM,期刊：Journal of clinical investigation, 页码：671-682 , 文章类型： Article，,卷期：2008年118-2]
- APOE genotype is a major genetic risk factor for late-onset Alzheimer disease (AD). ABCA1, a member of the ATP-binding cassette family of active transporters, lipidates apoE in the CNS. Abca1(-/-) mice have decreased lip...
- PPAR alpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice
[作者：Tanaka, N; Moriya, K; Kiyosawa, K; Koike, K; Gonzalez, FJ; Aoyama, T,期刊：Journal of clinical investigation, 页码：683-694 , 文章类型： Article，,卷期：2008年118-2]
- Transgenic mice expressing HCV core protein develop hepatic steatosis and hepatocellular carcinoma (HCC), but the mechanism underlying this process remains unclear. Because PPAR alpha is a central regulator of triglyceri...
- Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells
[作者：Arenas, F; Hervias, I; Uriz, M; Joplin, R; Prieto, J; Medina, JF,期刊：Journal of clinical investigation, 页码：695-709 , 文章类型： Article，,卷期：2008年118-2]
- Primary biliary cirrhosis (PBC) is a cholestatic disease associated with autoinimune phenomena and alterations in both biliary bicarbonate excretion and expression of the bicarbonate carrier AE2. The bile acid ursodeoxyc...
- Loss of PIP5KI gamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes
[作者：Wang, YF; Litvinov, RI; Chen, XS; Bach, TL; Lian, LR; Petrich, BG; Monkley, SJ; Critchley, DR; Sasaki, T; Birnbaum, MJ; Weisel, JW; Hartwig, J; Abrams, CS,期刊：Journal of clinical investigation, 页码：812-819 , 文章类型： Article，,卷期：2008年118-2]
- Phosphatidylinositol-4,5-bisphosphate (PIP2) is an abundant phospholipid that contributes to second messenger formation and has also been shown to contribute to the regulation of cytoskeletal dynamics in all eukaryotic c...
- Intestinal adherence associated with type IV pili of enterohemorrhagic Escherichia coli O157 : H7 (vol 117, pg 3519, 2007)
[作者：Xicohtencatl-Cortes, J; Monteiro-Neto, V; Ledesma, MA; Jordan, DM; Francetic, O; Kaper, JB; Puente, JL; Giron, JA,期刊：Journal of clinical investigation, 页码：820-820 , 文章类型： Correction，,卷期：2008年118-2]
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- Physiological systems under pressure
[作者：Marks, AR,期刊：Journal of clinical investigation, 页码：411-412 , 文章类型： Editorial Material，,卷期：2008年118-2]
- The marked disruption of the homeostasis of a physiological system, be it a cell, tissue, organ, or whole organism, is more commonly known as stress. In many ways, aging can be considered the ultimate stress. However, ph...
- Bone building with bortezomib
[作者：Roodman, GD,期刊：Journal of clinical investigation, 页码：462-464 , 文章类型： Editorial Material，,卷期：2008年118-2]
- In this issue of the JCI, Mukherjee et al. report that bortezomib, a clinically available proteasome inhibitor active against myeloma, induces the differentiation of mesenchymal stem/progenitor cells (MSCs) - rather than...
- In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue
[作者：Nishimura, S; Manabe, I; Nagasaki, M; Seo, K; Yamashita, H; Hosoya, Y; Ohsugi, M; Tobe, K; Kadowaki, T; Nagai, R; Sugiura, S,期刊：Journal of clinical investigation, 页码：710-721 , 文章类型： Article，,卷期：2008年118-2]
- To assess physiological and pathophysiological events that involve dynamic interplay between multiple cell types, real-time, in vivo analysis is necessary. We developed a technique based on confocal laser microscopy that...
- Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia
[作者：Yuan, B; Takaiwa, M; Clemens, TL; Feng, JQ; Kumar, R; Rowe, PS; Xie, YX; Drezner, MK,期刊：Journal of clinical investigation, 页码：722-734 , 文章类型： Article，,卷期：2008年118-2]
- Patients with X-linked hypophosphatemia (XLH) and the hyp-mouse, a model of XLH characterized by a deletion in the Phex gene, manifest hypophosphatemia, renal phosphate wasting, and rickets/osteomalacia. Cloning of the P...
- Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice
[作者：Degauque, N; Mariat, C; Kenny, J; Zhang, D; Gao, W; Vu, MD; Alexopoulos, S; Oukka, M; Umetsu, DT; DeKruyff, RH; Kuchroo, V; Zheng, XX; Strom, TB,期刊：Journal of clinical investigation, 页码：735-741 , 文章类型： Article，,卷期：2008年118-2]
- T cell Ig mucin (Tim) molecules modulate CD4(+) T cell responses. In keeping with the view that Tim-1 generates a stimulatory signal for CD4(+) T cell activation, we hypothesized that an agonist Tim-1-specific mAb would ...
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