个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共38条记录   HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice [作者：Hisatomi, T; Nakazawa, T; Noda, K; Almulki, L; Miyahara, S; Nakao, S; Ito, Y; She, HC; Kohno, R; Michaud, N; Ishibashi, T; Hafezi-Moghadam, A; Badley, AD; Kroemer, G; Miller, JW,期刊：Journal of clinical investigation, 页码：2025-2038 , 文章类型： Article，,卷期：2008年118-6] Neuroprotection can be achieved by preventing apoptotic death of postmitotic cells. Apoptotic death can occur by either a caspase-dependent mechanism, involving cytochrome c, apoptosis protease-activating factor-1 (Apaf-... Availability of activated CD4(+) T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys [作者：Klatt, NR; Villinger, F; Bostik, P; Gordon, SN; Pereira, L; Engram, JC; Mayne, A; Dunham, RM; Lawson, B; Ratcliffe, SJ; Sodora, DL; Else, J; Reimann, K; Staprans, SI; Haase, AT; Estes, JD; Silvestri, G; Ansari, AA,期刊：Journal of clinical investigation, 页码：2039-2049 , 文章类型： Article，,卷期：2008年118-6] Naturally SIV-infected sooty mangabeys (SMs) remain asymptomatic despite high virus replication. Elucidating the mechanisms underlying AIDS resistance of SIV-infected SMs may provide crucial information to better underst... p21(Cip1) modulates arterial wound repair through the stromal cell-derived factor-1/CXCR4 axis in mice [作者：Olive, M; Mellad, JA; Beltran, LE; Ma, MC; Cimato, T; Noguchi, AC; San, H; Childs, R; Kovacic, JC; Boehm, M,期刊：Journal of clinical investigation, 页码：2050-2061 , 文章类型： Article，,卷期：2008年118-6] Cyclin-dependent kinase inhibitors, including p21(Cip1), are implicated in cell turnover and are active players in cardiovascular wound repair. Here, we show that p21(Cip1) orchestrates the complex interactions between l... Bone marrow cells recruited through the neuropilin-1 receptor promote arterial formation at the sites of adult neoangiogenesis in mice [作者：Zacchigna, S; Pattarini, L; Zentilin, L; Moimas, S; Carrer, A; Sinigaglia, M; Arsic, N; Tafuro, S; Sinagra, G; Giacca, M,期刊：Journal of clinical investigation, 页码：2062-2075 , 文章类型： Article，,卷期：2008年118-6] Experimental and clinical evidence indicate that bone marrow cells participate in the process of new blood vessel formation. However, the molecular mechanisms underlying their recruitment and their exact role are still e... A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition [作者：Schuhmacher, AJ; Guerra, C; Sauzeau, V; Canamero, M; Bustelo, XR; Barbacid, M,期刊：Journal of clinical investigation, 页码：2169-2179 , 文章类型： Article，,卷期：2008年118-6] Germline activation of H-PAS oncogenes is the primary cause of Costello syndrome (CS), a neuro-carctio-faciocutaneous developmental syndrome. Here we describe the generation of a mouse model of CS by introduction of an o... Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells [作者：Li, HW; Armando, I; Yu, PY; Escano, C; Mueller, SC; Asico, L; Pascua, A; Lu, QS; Wang, XY; Villar, VM; Jones, JE; Wang, Z; Periasamy, A; Lau, YS; Soares-da-Silva, P; Creswell, K; Guillemette, G; Sibley, DR; Eisner, G; Felder, RA; Jose, PA,期刊：Journal of clinical investigation, 页码：2180-2189 , 文章类型： Article，,卷期：2008年118-6] Hypertension is a multigenic disorder in which abnormal counterregulation between dopamine and Ang II plays a role. Recent studies suggest that this counterregulation results, at least in part, from regulation of the exp... The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice [作者：Pickford, F; Masliah, E; Britschgi, M; Lucin, K; Narasimhan, R; Jaeger, PA; Small, S; Spencer, B; Rockenstein, E; Levine, B; Wyss-Coray, T,期刊：Journal of clinical investigation, 页码：2190-2199 , 文章类型： Article，,卷期：2008年118-6] Autophagy is the principal cellular pathway for degradation of long-lived proteins and organelles and regulates cell fate in response to stress. Recently, autophagy has been implicated in neurodegeneration, but whether i... Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans [作者：Tan, HY; Nicodemus, KK; Chen, Q; Li, Z; Brooke, JK; Honea, R; Kolachana, BS; Straub, RE; Meyer-Lindenberg, A; Sei, Y; Mattay, VS; Callicott, JH; Weinberger, DR,期刊：Journal of clinical investigation, 页码：2200-2208 , 文章类型： Article，,卷期：2008年118-6] AKT1-dependent molecular pathways control diverse aspects of cellular development and adaptation, including interactions with neuronal dopaminergic signaling. if AKT1 has an impact on dopaminergic signaling, then genetic... Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice [作者：Wu, ML; Li, J; Engleka, KA; Zhou, B; Lu, MM; Plotkin, JB; Epstein, JA,期刊：Journal of clinical investigation, 页码：2076-2087 , 文章类型： Article，,卷期：2008年118-6] Transcription factors regulate tissue patterning and cell fate determination during development; however, expression of early regulators frequently abates upon differentiation, suggesting that they may also play a role i... Re1A/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice [作者：Vaira, S; Alhawagri, M; Anwisye, I; Kitaura, H; Faccio, R; Novack, DV,期刊：Journal of clinical investigation, 页码：2088-2097 , 文章类型： Article，,卷期：2008年118-6] Osteoclasts (OCs) function to reabsorb bone and are responsible for the bone loss associated with inflammatory arthritis and osteoporosis. OC numbers are elevated in most disorders of accelerated bone destruction, reflec... Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin [作者：Sancho, D; Mourao-Sa, D; Joffre, OP; Schulz, O; Rogers, NC; Pennington, DJ; Carlyle, JR; Sousa, CRE,期刊：Journal of clinical investigation, 页码：2098-2110 , 文章类型： Article，,卷期：2008年118-6] The mouse CD8 alpha(+) DC subset excels at cross-presentation of antigen, which can elicit robust CTL responses. A receptor allowing specific antigen targeting to this subset and its equivalent in humans would therefore ... CD133 expression is not restricted to stem cells, and both CD133(+) and CD133(-) metastatic colon cancer cells initiate tumors [作者：Shmelkov, SV; Butler, JM; Hooper, AT; Hormigo, A; Kushner, J; Milde, T; St Clair, R; Baljevic, M; White, I; Jin, DK; Chadburn, A; Murphy, AJ; Valenzuela, DM; Gale, NW; Thurston, G; Yancopoulos, GD; D'Angelica, M; Kemeny, N; Lyden, D; Rafii, S,期刊：Journal of clinical investigation, 页码：2111-2120 , 文章类型： Article，,卷期：2008年118-6] Colon cancer stem cells are believed to originate from a rare population of putative CD133(+) intestinal stem cells. Recent publications suggest that a small subset of colon cancer cells expresses CD133, and that only th... Inherited human cPLA(2 alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction [作者：Adler, DH; Cogan, JD; Phillips, JA; Schnetz-Boutaud, N; Milne, GL; Iverson, T; Stein, JA; Brenner, DA; Morrow, JD; Boutaud, O; Oates, JA,期刊：Journal of clinical investigation, 页码：2121-2131 , 文章类型： Article，,卷期：2008年118-6] Cytosolic phospholipase A(2 alpha) (cPLA(2 alpha)) hydrolyzes arachidonic acid from cellular membrane phospholipids, thereby providing enzymatic substrates for the synthesis of eicosanoids, such as prostaglandins and leu... Central insulin action regulates peripheral glucose and fat metabolism in mice [作者：Koch, L; Wunderlich, FT; Seibler, J; Konner, AC; Hampel, B; Irlenbusch, S; Brabant, G; Kahn, CR; Schwenk, F; Bruning, JC,期刊：Journal of clinical investigation, 页码：2132-2147 , 文章类型： Article，,卷期：2008年118-6] Insulin resistance is a hallmark of type 2 diabetes, and many insights into the functions of insulin have been gained through the study of mice lacking the IR. To gain a better understanding of the role of insulin action... Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus [作者：Colombo, C; Porzio, O; Liu, M; Massa, O; Vasta, M; Salardi, S; Beccaria, L; Monciotti, C; Toni, S; Pedersen, O; Hansen, T; Federici, L; Pesavento, R; Cadario, F; Federici, G; Ghirri, P; Arvan, P; Lafusco, D; Barbetti, F,期刊：Journal of clinical investigation, 页码：2148-2156 , 文章类型： Article，,卷期：2008年118-6] Permanent neonatal diabetes mellitus (PNDM) is a rare disorder usually presenting within 6 months of birth. Although several genes have been linked to this disorder, in almost half the cases documented in Italy, the gene... GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak [作者：Weber, YG; Storch, A; Wuttke, TV; Brockmann, K; Kempfle, J; Maljevic, S; Margari, L; Kamm, C; Schneider, SA; Huber, SM; Pekrun, A; Roebling, R; Seebohm, G; Koka, S; Lang, C; Kraft, E; Blazevic, D; Salvo-Vargas, A; Fauler, M; Mottaghy, FM; Munchau, A; Edwards, MJ; Presicci, A; Margari, F; Gasser, T; Lang, F; Bhatia, KP; Lehmann-Horn, F; Lerche, H,期刊：Journal of clinical investigation, 页码：2157-2168 , 文章类型： Article，,卷期：2008年118-6] Paroxysmal dyskinesias are episodic movement disorders that can be inherited or are sporadic in nature. The pathophysiology underlying these disorders remains largely unknown but may involve disrupted ion homeostasis due...