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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共27条记录   Paraspeckle protein p54(nrb) links Sox9-mediated transcription with RNA processing during chondrogenesis in mice [作者：Hata, K; Nishimura, R; Muramatsu, S; Matsuda, A; Matsubara, T; Amano, K; Ikeda, F; Harley, VR; Yoneda, T,期刊：Journal of clinical investigation, 页码：3098-3108 , 文章类型： Article，,卷期：2008年118-9] The Sox9 transcription factor plays an essential role in promoting chondrogenesis and regulating expression of chondrocyte extracellular-matrix genes. To identify genes that interact with Sox9 in promoting chondrocyte di... Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins [作者：Ziegler, DS; Wright, RD; Kesari, S; Lemieux, ME; Tran, MA; Jain, M; Zawel, L; Kung, AL,期刊：Journal of clinical investigation, 页码：3109-3122 , 文章类型： Article，,卷期：2008年118-9] Multiple receptor tyrosine kinases (RTKs), including PDGFR, have been validated as therapeutic targets in glioblastoma multiforme (GBM), yet inhibitors of RTKs have had limited clinical success. As various antiapoptotic ... Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1 [作者：Stoltz, DA; Ozer, EA; Taft, PJ; Barry, M; Liu, L; Kiss, PJ; Moninger, TO; Parsek, MR; Zabner, J,期刊：Journal of clinical investigation, 页码：3123-3131 , 文章类型： Article，,卷期：2008年118-9] Pseudomonas aeruginosa uses quorum sensing, an interbacterial communication system, to regulate gene expression. The signaling molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) is thought to play a central role i... Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1 [作者：Hacein-Bey-Abina, S; Garrigue, A; Wang, GP; Soulier, J; Lim, A; Morillon, E; Clappier, E; Caccavelli, L; Delabesse, E; Beldjord, K; Asnafi, V; Macintyre, E; Dal Cortivo, L; Radford, I; Brousse, N; Sigaux, F; Moshous, D; Hauer, J; Borkhardt, A; Belohradsky, BH; Wintergerst, U; Velez, MC; Leiva, L; Sorensen, R; Wulffraat, N; Blanche, S; Bushman, FD; Fischer, A; Cavazzana-Calvo, M,期刊：Journal of clinical investigation, 页码：3132-3142 , 文章类型： Article，,卷期：2008年118-9] Previously, several individuals with X-linked SCID (SCID-X1) were treated by gene therapy to restore the missing IL-2 receptor gamma (IL2RG) gene to CD34(+) BM precursor cells using gammaretroviral vectors. While 9 of 10... Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice [作者：Gong, YQ; Hart, E; Shchurin, A; Hoover-Plow, J,期刊：Journal of clinical investigation, 页码：3012-3024 , 文章类型： Article，,卷期：2008年118-9] Inflammation plays a critical role in the development of cardiovascular diseases. Infiltration of leukocytes to sites of injury requires their exit from the blood and migration across basement membrane; this process has ... The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans [作者：Toyama, K; Wulff, H; Chandy, KG; Azam, P; Raman, G; Saito, T; Fujiwara, Y; Mattson, DL; Das, S; Melvin, JE; Pratt, PF; Hatoum, OA; Gutterman, DD; Harder, DR; Miura, H,期刊：Journal of clinical investigation, 页码：3025-3037 , 文章类型： Article，,卷期：2008年118-9] Atherosclerosis remains a major cause of death in the developed world despite the success of therapies that lower cholesterol and BP. The intermediate-conductance calcium-activated potassium channel KCa3.1 is expressed i... Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL(+) leukemia cells [作者：Kharas, MG; Janes, MR; Scarfone, VM; Lilly, MB; Knight, ZA; Shokat, KM; Fruman, DA,期刊：Journal of clinical investigation, 页码：3038-3050 , 文章类型： Article，,卷期：2008年118-9] Some cases of pre-B cell acute lymphoblastic leukemia (pre-B-ALL) are caused by the Philadelphia (Ph) chromosome-encoded BCR-ABL oncogene, and these tend to have a poor prognosis. Inhibitors of the PI3K/AKT pathway reduc... Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model [作者：Kinkade, CW; Castillo-Martin, M; Puzio-Kuter, A; Yan, J; Foster, TH; Gao, H; Sun, Y; Ouyang, XS; Gerald, WL; Cordon-Cardo, C; Abate-Shen, C,期刊：Journal of clinical investigation, 页码：3051-3064 , 文章类型： Article，,卷期：2008年118-9] The AKT/mammalian target of rapamycin (AKT/mTOR) and ERK MAPK signaling pathways have been shown to cooperate in prostate cancer progression and the transition to androgen-independent disease. We have now tested the effe... Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer [作者：Carracedo, A; Ma, L; Teruya-Feldstein, J; Rojo, F; Salmena, L; Alimonti, A; Egia, A; Sasaki, AT; Thomas, G; Kozma, SC; Papa, A; Nardella, C; Cantley, LC; Baselga, J; Pandolfi, PP,期刊：Journal of clinical investigation, 页码：3065-3074 , 文章类型： Article，,卷期：2008年118-9] Numerous studies have established a causal link between aberrant mammalian target of rapamycin (mTOR) activation and tumorigenesis, indicating that mTOR inhibition may have therapeutic potential. In this study, we show t... Palmitoyl protein thioesterase-1 deficiency impairs synaptic vesicle recycling at nerve terminals, contributing to neuropathology in humans and mice [作者：Kim, SJ; Zhang, ZJ; Sarkar, C; Tsai, PC; Lee, YC; Dye, L; Mukherjee, AB,期刊：Journal of clinical investigation, 页码：3075-3086 , 文章类型： Article，,卷期：2008年118-9] Neuronal ceroid lipofuscinoses represent the most common childhood neurodegenerative storage disorders. Infantile neuronal ceroid lipofuscinosis (INCL) is caused by palmitoyl protein thioesterase-1 (PPT1) deficiency. Alt... HsP104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease [作者：Lo Bianco, C; Shorter, J; Regulier, E; Lashuel, H; Iwatsubo, T; Lindquist, S; Aebischer, P,期刊：Journal of clinical investigation, 页码：3087-3097 , 文章类型： Article，,卷期：2008年118-9] Parkinson disease (PD) is characterized by dopaminergic neurodegeneration and intracellular inclusions of alpha-synuclein amyloid fibers, which are stable and difficult to dissolve. Whether inclusions are neuroprotective... Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients [作者：Howe, SJ; Mansour, MR; Schwarzwaelder, K; Bartholomae, C; Hubank, M; Kempski, H; Brugman, MH; Pike-Overzet, K; Chatters, SJ; de Ridder, D; Gilmour, KC; Adams, S; Thornhill, SI; Parsley, KL; Staal, FJT; Gale, RE; Linch, DC; Bayford, J; Brown, L; Quaye, M; Kinnon, C; Ancliff, P; Webb, DK; Schmidt, M; von Kalle, C; Gaspar, HB; Thrasher, AJ,期刊：Journal of clinical investigation, 页码：3143-3150 , 文章类型： Article，,卷期：2008年118-9] X-linked SCID (SCID-X1) is amenable to correction by gene therapy using conventional gammaretroviral vectors. Here, we describe the occurrence of clonal T cell acute lymphoblastic leukemia (T-ALL) promoted by insertional... The PKC inhibitor AEB071 may be a therapeutic option for psoriasis [作者：Skvara, H; Dawid, M; Kleyn, E; Wolff, B; Meingassner, JG; Knight, H; Dumortier, T; Kopp, T; Fallahi, N; Stary, G; Burkhart, C; Grenet, O; Wagner, J; Hijazi, Y; Morris, RE; McGeown, C; Rordorf, C; Griffiths, CEM; Stingl, G; Jung, T,期刊：Journal of clinical investigation, 页码：3151-3159 , 文章类型： Article，,卷期：2008年118-9] PKC isoforms tau, alpha, and beta play fundamental roles in the activation of T cells and other immune cell functions. Here we show that the PKC inhibitor AEB071 both abolishes the production of several cytokines by acti... Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice [作者：Osei-Hyiaman, D; Liu, J; Zhou, L; Godlewski, G; Harvey-White, J; Jeong, WI; Batkai, S; Marsicano, G; Lutz, B; Buettner, C; Kunos, G,期刊：Journal of clinical investigation, 页码：3160-3169 , 文章类型： Article，,卷期：2008年118-9] Diet-induced obesity is associated with fatty liver, insulin resistance, leptin resistance, and changes in plasma lipid profile. Endocannabinoids have been implicated in the development of these associated phenotypes, be... Colchicine inhibits pressure-induced tumor cell implantation within surgical wounds and enhances tumor-free survival in mice [作者：Craig, DH; Owen, CR; Conway, WC; Walsh, MF; Downey, C; Basson, MD,期刊：Journal of clinical investigation, 页码：3170-3180 , 文章类型： Article，,卷期：2008年118-9] Iatrogenic tumor cell implantation within surgical wounds can compromise curative cancer surgery. Adhesion of cancer cells, in particular colon cancer cells, is stimulated by exposure to increased extracellular pressure ... Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia [作者：Chiang, MY; Xu, LW; Shestova, O; Histen, G; L'Heureux, S; Romany, C; Childs, ME; Gimotty, PA; Aster, JC; Pear, WS,期刊：Journal of clinical investigation, 页码：3181-3194 , 文章类型： Article，,卷期：2008年118-9] Gain-of-function NOTCH1 mutations are found in 50%-70% of human T cell acute lymphoblastic leukemia/ lymphoma (T-ALL) cases. Gain-of-function NOTCH1 alleles that initiate strong downstream signals induce leukemia in mice...