- KIS protects against adverse vascular remodeling by opposing stathmin-mediated VSMC migration in mice
[作者:Langenickel, TH; Olive, M; Boehm, M; San, H; Crook, MF; Nabel, EG,期刊:Journal of clinical investigation, 页码:3848-3859 , 文章类型: Article,,卷期:2008年118-12]
- Vascular proliferative diseases are characterized by VSMC proliferation and migration. Kinase interacting with stathmin (KIS) targets 2 key regulators of cell proliferation and migration, the cyclin-dependent kinase inhi...
- A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification
[作者:Kalabis, J; Oyama, K; Okawa, T; Nakagawa, H; Michaylira, CZ; Stairs, DB; Figueiredo, JL; Mahmood, U; Diehl, JA; Herlyn, M; Rustgi, AK,期刊:Journal of clinical investigation, 页码:3860-3869 , 文章类型: Article,,卷期:2008年118-12]
- The esophageal epithelium is a prototypical stratified squamous epithelium that exhibits an exquisite equilibrium between proliferation and differentiation. After basal cells proliferate, they migrate outward toward the ...
- An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice
[作者:Sheikh, F; Raskin, A; Chu, PH; Lange, S; Domenighetti, AA; Zheng, M; Liang, XQ; Zhang, T; Yajima, T; Gu, Y; Dalton, ND; Mahata, SK; Dorn, GW; Heller-Brown, J; Peterson, KL; Omens, JH; McCulloch, AD; Chen, J,期刊:Journal of clinical investigation, 页码:3870-3880 , 文章类型: Article,,卷期:2008年118-12]
- The response of cardiomyocytes to biomechanical stress can determine the pathophysiology of hypertrophic cardiac disease, and targeting the pathways regulating these responses is a therapeutic goal. However, little is kn...
- Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters
[作者:Broer, S; Bailey, CG; Kowalczuk, S; Ng, C; Vanslambrouck, JM; Rodgers, H; Auray-Blais, C; Cavanaugh, JA; Broer, A; Rasko, JEJ,期刊:Journal of clinical investigation, 页码:3881-3892 , 文章类型: Article,,卷期:2008年118-12]
- Iminoglycinuria (IG) is an autosomal recessive abnormality of renal transport of glycine and the imino acids proline and hydroxyproline, but the specific genetic defect(s) have not been determined. Similarly, although th...
- Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice
[作者:Baudenbacher, F; Schober, T; Pinto, JR; Sidorov, VY; Hilliard, F; Solaro, RJ; Potter, JD; Knollmann, BC,期刊:Journal of clinical investigation, 页码:3893-3903 , 文章类型: Article,,卷期:2008年118-12]
- In human cardiomyopathy, anatomical abnormalities such as hypertrophy and fibrosis contribute to the risk of ventricular arrhythmias and sudden death. Here we have shown that increased myofilament Ca2+ sensitivity, also ...
- AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice
[作者:Zhang, HF; He, Y; Dai, SC; Xu, Z; Luo, Y; Wan, T; Luo, DH; Jones, D; Tang, SB; Chen, H; Sessa, WC; Min, W,期刊:Journal of clinical investigation, 页码:3904-3916 , 文章类型: Article,,卷期:2008年118-12]
- ASK1-interacting protein-1 (AIPI), a recently identified member of the Ras GTPase-activating protein family, is highly expressed in vascular ECs and regulates EC apoptosis in vitro. However, its function in vivo has not ...
- The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells
[作者:Lu, Z; Luo, RZ; Lu, YL; Zhang, XH; Yu, QH; Khare, S; Kondo, S; Kondo, Y; Yu, YH; Mills, GB; Liao, WSL; Bast, RC,期刊:Journal of clinical investigation, 页码:3917-3929 , 文章类型: Article,,卷期:2008年118-12]
- The role of autophagy in oncogenesis remains ambiguous, and mechanisms that induce autophagy and regulate its outcome in human cancers are poorly understood. The maternally imprinted Ras-related tumor suppressor gene apl...
- Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
[作者:Sonveaux, P; Vegran, F; Schroeder, T; Wergin, MC; Verrax, J; Rabbani, ZN; De Saedeleer, CJ; Kennedy, KM; Diepart, C; Jordan, BF; Kelley, MJ; Gallez, B; Wahl, ML; Feron, O; Dewhirst, MW,期刊:Journal of clinical investigation, 页码:3930-3942 , 文章类型: Article,,卷期:2008年118-12]
- Tumors contain oxygenated and hypoxic regions, so the tumor cell population is heterogeneous. Hypoxic tumor cells primarily use glucose for glycolytic energy production and release lactic acid, creating a lactate gradien...
- Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation
[作者:Hui, LJ; Zatloukal, K; Scheuch, H; Stepniak, E; Wagner, EF,期刊:Journal of clinical investigation, 页码:3943-3953 , 文章类型: Article,,卷期:2008年118-12]
- JNK proteins have been shown to be involved in liver carcinogenesis in mice, but the extent of their involvement in the development of human liver cancers is unknown. Here, we show that activation of JNK1 but not JNK2 wa...
- Uterine DCs are crucial for decidua formation during embryo implantation in mice
[作者:Plaks, V; Birnberg, T; Berkutzki, T; Sela, S; BenYashar, A; Kalchenko, V; Mor, G; Keshet, E; Dekel, N; Neeman, M; Jung, S,期刊:Journal of clinical investigation, 页码:3954-3979 , 文章类型: Article,,卷期:2008年118-12]
- Implantation is a key stage during pregnancy, as the fate of the embryo is often decided upon its first contact with the maternal endometrium. Around this time, DCs accumulate in the uterus; however, their role in pregna...
- Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase-gene rated superoxide
[作者:Straub, AC; Clark, KA; Ross, MA; Chandra, AG; Li, S; Gao, X; Pagano, PJ; Stolz, DB; Barchowsky, A,期刊:Journal of clinical investigation, 页码:3980-3989 , 文章类型: Article,,卷期:2008年118-12]
- Environmental arsenic exposure, through drinking contaminated water, is a significant risk factor for developing vascular diseases and is associated with liver portal hypertension, vascular shunting, and portal fibrosis ...
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