- Islet beta-cell-specific T cells can use different homing mechanisms to infiltrate and destroy pancreatic islets (vol 170, pg 240, 2007)
[作者:Hanninen, A; Nurmela, R; Maksimow, M; Heino, J; Jalkanen, S; Kurts, C,期刊:American Journal of Pathology, 页码:1153-1153 , 文章类型: Correction,,卷期:2008年172-4]
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- Zinc supplementation enhances hepatic regeneration by preserving hepatocyte nuclear factor-4 alpha in mice subjected to long-term ethanol administration
[作者:Kang, XQ; Song, ZY; McClain, CJ; Kang, YJ; Zhou, ZX,期刊:American Journal of Pathology, 页码:916-925 , 文章类型: Article,,卷期:2008年172-4]
- Alcoholic liver disease is associated with sustained liver damage and impaired regeneration, as well as significant zinc deficiency. This study was undertaken to examine whether dietary zinc supplementation could improve...
- Up-regulation of MSX2 enhances the malignant phenotype and is associated with Twist 1 expression in human pancreatic cancer cells
[作者:Satoh, K; Hamada, S; Kimura, K; Kanno, A; Hirota, M; Umino, J; Fujibuchi, W; Masamune, A; Tanaka, N; Miura, K; Egawa, S; Motoi, F; Unno, M; Vonderhaar, BK; Shimosegawa, T,期刊:American Journal of Pathology, 页码:926-939 , 文章类型: Article,,卷期:2008年172-4]
- MSX2 is thought to be a regulator of organ development and a downstream target of the ras signaling pathway; however, little is known about the role of MSX2 in the development of pancreatic cancers, most of which harbor ...
- Rheumatoid arthritis synovium contains two subsets of CD83(-)DC(-)LAMP(-) dendritic cells with distinct cytokine profiles
[作者:Lebre, MC; Jongbloed, SL; Tas, SW; Smeets, TJM; Mclnnes, LB; Tak, PP,期刊:American Journal of Pathology, 页码:940-950 , 文章类型: Article,,卷期:2008年172-4]
- Dendritic cells (DCs) have been proposed to play a pivotal role in the initiation and perpetuation of rheumatoid arthritis (RA) by presentation of arthritogenic antigens to T cells. We investigated the in vivo characteri...
- Bone morphogenetic proteins are overexpressed in the bone marrow of primary myelofibrosis and are apparently induced by fibrogenic cytokines
[作者:Bock, O; Hoftmann, J; Theophile, K; Hussein, K; Wiese, B; Schlue, J; Kreipe, H,期刊:American Journal of Pathology, 页码:951-960 , 文章类型: Article,,卷期:2008年172-4]
- Primary myelofibrosis (PMF) is a myeloproliferative neoplasia characterized by progressive deposition of extracellular matrix components in the bone marrow. The involvement of members of the bone morphogenetic protein (B...
- Revisiting the Koebner phenomenon - Role of NGF and its receptor system in the pathogenesis of psoriasis
[作者:Raychaudhuri, SP; Jiang, WY; Raychaudhuri, SK,期刊:American Journal of Pathology, 页码:961-971 , 文章类型: Article,,卷期:2008年172-4]
- Nerve growth factor (NGF) influences the key pathological events of psoriasis: keratinocyte proliferation, angiogenesis, and T-cell activation. We have systematically examined the kinetics of NGF expression, keratinocyte...
- Induction of active tolerance and involvement of CD1d-restricted natural killer T cells in anti-CD3 F(ab ')(2) treatment-reversed new-onset diabetes in nonobese diabetic mice
[作者:Chen, GJ; Han, GC; Wang, JA; Wang, RX; Xu, RN; Shen, BF; Qian, JH; Li, Y,期刊:American Journal of Pathology, 页码:972-979 , 文章类型: Article,,卷期:2008年172-4]
- The application of anti-CD3 F(ab ')(2) monoclonal antibodies has recently been expanded to treat established autoimmune diseases, including type 1 diabetes. However, the mechanism underlying their effect remains largely ...
- Antigen-induced Pten gene deletion in T cells exacerbates neuropathology in experimental autoimmune encephalomyelitis
[作者:Johnson, TA; Tsutsui, S; Jirik, FR,期刊:American Journal of Pathology, 页码:980-992 , 文章类型: Article,,卷期:2008年172-4]
- The Pten tumor suppressor gene is critical for normal intrathymic development of T cells; however, its role in mature antigen-activated T cells is less well defined. A genetically crossed mouse line, Pten(fl/fl) GBC, in ...
- Age-related changes in bone morphology are accelerated in group VIA phospholipase A(2) (iPLA(2)beta)-null mice
[作者:Ramanadham, S; Yarasheski, KE; Silva, MJ; Wohltmann, M; Novack, DV; Christiansen, B; Tu, XL; Zhang, S; Lei, XY; Turk, J,期刊:American Journal of Pathology, 页码:868-881 , 文章类型: Article,,卷期:2008年172-4]
- Phospholipases A(2) (PLA(2)) hydrolyze the sn-2 fatty acid substituent, such as arachidonic acid, from phospholipids, and arachidonate metabolites are recognized mediators of bone modeling. We have previously generated k...
- Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury
[作者:Toivola, DM; Nakamichi, I; Strnad, P; Michie, SA; Ghori, N; Harada, M; Zeh, K; Oshima, RG; Baribault, H; Omary, MB,期刊:American Journal of Pathology, 页码:882-892 , 文章类型: Article,,卷期:2008年172-4]
- Mutation of the adult hepatocyte keratins K8 and K18 predisposes to liver disease. In contrast, exocrine pancreas K8 and K18 are dispensable and are co-expressed with limited levels of membrane-proximal K19 and K20. Over...
- Lymphadenopathy in a novel mouse model of Bartonella-induced cat scratch disease results from lymphocyte immigration and proliferation and is regulated by interferon-alpha/beta
[作者:Kunz, S; Oberle, K; Sander, A; Bogdan, C; Schleicher, U,期刊:American Journal of Pathology, 页码:1005-1018 , 文章类型: Article,,卷期:2008年172-4]
- In immunocompetent humans, cat scratch disease (CSD) is elicited by the Gram-negative bacterium Bartonella henselae and is characterized by a benign regional lymphadenopathy, the pathogenesis of which is poorly understoo...
- Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1
[作者:Huang, W; Zhang, Y; Varambally, S; Chinnaiyan, AM; Banerjee, M; Merajver, SD; Kleer, CG,期刊:American Journal of Pathology, 页码:893-904 , 文章类型: Article,,卷期:2008年172-4]
- The cysteine-rich protein CCN6 [or Wnt-1-induced signaling protein 3 (WISP3)] exerts tumor-suppressive effects in aggressive inflammatory breast cancer. Loss of CCN6 is associated with poorly differentiated phenotypes an...
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